Upper and Lower Gastrointestinal Bleeding
Dr. Shatdal Chaudhary MD Assistant Professor Department of Internal Medicine, BPKIHS, Dharan
G I Bleeding • Acute Vs Chronic • Upper Vs Lower • Bleeding above/below the ligament of Treitz
Acute U G I Bleeding Introduction • Most common gastrointestinal emergency • Accounting for 50-120 admissions to hospital per 100 000 of the population each year in the U K. • Higher among males, elderly
Causes of Upper GI Bleed (UGIB) • • • • • • •
Peptic Ulcer Disease (60% cases of UGIB) Erosive Gastritis(10-20%) Esophagitis (10%) Esophageal and Gastric Varices (2-9%) Mallory-Weiss Syndrome(5%) Malignancy(2%) Others – Stress ulcer, arteriovenous malformation, Aortoduodenal Fistula, corrosive poisoning
Clinical Features: • History: Often misleading – Usually presents with obvious complaints (melaena, hematemesis, etc.) or may present with more subtle signs (hypotension, tachycardia, etc)
• • • • • •
Hematemesis Melaena Hematochezia H/o NSAIDs, Alcohol abuse, corrosive intake Weight loss/change in bowel habit (malignancy) Vomiting/retching followed by hematemesis (MalloryWeiss) • Hx aortic graft (possible aortocentric fistula)
Clinical Features: • Physical Exam – Hypotension, tachycardia – Skin: cool, clammy, jaundice, spider angioma and other stigmata of CLD – Lymph node – Abd: tenderness, masses, ascites, hepatosplenomegaly – PR Exam: blood
Estimation of blood loss
Estimated Fluid and Blood Losses in Shock Class 1
Class 2
Class 3
Blood Loss, mL
Up to 750
750-1500
1500-2000
>2000
Blood Loss,% blood volume
Up to 15%
15-30%
30-40%
>40%
<100
>100
>120
>140
Normal
Normal
Decreased
Decreased
Normal or Increased
Decreased
Decreased
Decreased
14-20
20-30
30-40
Slightly anxious
Mildly anxious
Anxious, confused
Crystalloid
Crystalloid
Crystalloid and blood
Pulse Rate, bpm Blood Pressure Respiratory Rate Urine Output, mL/h CNS/Mental Status Fluid Replacement, 3-for-1 rule
Class 4
>35 Confused, lethargic Crystalloid and blood
Investigations: Blood tests • Blood Group • Full blood count. Hb: may be normal or Low. • Urea and electrolytes. may show evidence of renal failure. • LFT. • Prothrombin time & Coagulation Profile. • Cross-matching of at least 2 units of blood.
• UGI Endoscopy: Diagnostic as well as therapeutic – should be carried out as early as possibe after adequate resuscitation. – A diagnosis will be achieved in 80% of cases. – Patients who are found to have major endoscopic stigmata of recent haemorrhage can be treated endoscopically
• Angiography: sometimes can localize, but requires brisk bleeding rate (0.5 to 2.0 ml/min) • Technetium-labeled red cell scan: more sensitive than angiography
Treatment • Primary – ABCs – Oxygen This should be given by facemask to all patients in shock. – Close monitoring – Immediate resuscitation, 2 wide bore IV cannula – NG tube in all patients with significant bleeding – Consider blood transfusion if no improvement after 2L of crystalloid or Hb < 10 gm/dL
Therapeutic Endoscopy – – – –
Early treatment indicated when significant upper GI bleed Sclerotherapy or band ligation used to treat varices thermal modality 'heater probe‘ injection of dilute adrenaline (epinephrine) into the bleeding point
– application of metallic clips.
Drug Therapy – Intravenous proton pump inhibitor infusions reduce rebleeding – Somatostatin and octreotide effective for reduction of acute variceal bleeding
Balloon Tamponade • Sengstaken-Blakemore tube can control variceal hemorrhage in 40 – 80% patients • Inflate gastric balloon first, the esophageal balloon if no improvement
Surgery – – if all other interventions are ineffective – endoscopic haemostasis fails to stop active bleeding – rebleeding occurs on one occasion in an elderly or frail patient, or twice in younger, fit patients
Prognosis: • Mortality following a diagnosis of acute upper gastrointestinal bleeding is approximately 10%.
RISK FACTORS FOR DEATH IN PATIENTS WITH ACUTE U GI HAEMORRHAGE Factor Comments • Increasing age: Risk increases over age 60 and especially in very elderly
•
Comorbidity:Advanced malignancy; renal and hepatic failure
• •
Shock: Diagnosis:
•
Endoscopic findings:
•
Rebleeding
Def as pulse > 100/min, BP < 100 Varices and cancer have the worst prognosis Active bleeding and a nonbleeding visible vessel at endoscopy Associated with 10-fold rise in mortality
Lower GI Bleeding • Bleeding below the ligament of Treitz • This may be due to haemorrhage from the – small bowel – colon or – anal canal
• Incidence: 20 per 100,000 population
CAUSES OF LOWER GI BLEEDING • Severe acute – – – –
Diverticular disease Angiodysplasia Ischaemia Meckel's diverticulum
• Moderate, chronic/subacute – – – – – – –
Anal disease, e.g. fissure, haemorrhoids Inflammatory bowel disease Carcinoma Large polyps Angiodysplasia Radiation enteritis Solitary rectal ulcer
ETIOLOGY Differential Diagnosis of Lower Gastrointestinal Hemorrhage COLONIC BLEEDING (95%) % SMALL BOWEL BLEEDING (5%) Diverticular disease
30-40 Angiodysplasias
Ischemia
5-10
Erosions or ulcers (potassium, NSAIDs)
Anorectal disease
5-15
Crohn's disease
Neoplasia
5-10
Radiation
Infectious colitis
3-8
Meckel's diverticulum
Postpolypectomy
3-7
Neoplasia
Inflammatory bowel disease
3-4
Aortoenteric fistula
Angiodysplasia
3
Radiation colitis/proctitis
1-3
Other
1-5
Unknown
10-25
Clinical Features • OCCULT GI BLEEDING • 'Occult' means that blood or its breakdown products are present in the stool but cannot be seen. • Occult bleeding may reach 200 ml per day
Options to diagnose and control the bleeding • Colonoscopy • technetium-99m labeled RBC scan: requires 0.5-1 ml/min bleeding • Mesenteric angiography: requires 1-1.5 ml/min bleeding • Meckels scan • Capsule Endoscopy • Surgery • faecal occult blood (FOB)
• Colonscopy: diagnostic and therapeutic • colonoscopy is necessary to exclude coexisting colorectal cancer. – subjects who also have altered bowel habit – and in all patients presenting at over 40 years of age,
Treatment • Acute bleeding tends to be self limiting • If bleeding persists perform endoscopy to exclude upper GI cause • Therapeutic colonoscopy • Consider selective mesenteric embolisation if life threatening haemorrhage • Proceed to laparotomy and consider on-table lavage an panendoscopy • If right-sided angiodysplasia perform a right hemicolectomy • If bleeding diverticular disease perform a sigmoid colectomy • If source of colonic bleeding unclear perform a subtotal colectomy and end-ileostomy
The End