Shaik Cv

CURRICULUM VITAE SHAIK AZEEZA

Senior Research Fellow Chemical Biology Laboratory Division of Organic Chemistry – I Indian Institute of Chemical Technology Tarnaka, Hyderabad-500 607, INDIA Phone: +91-40-27160123 Ext. 1633 Mobile: +91-9849857942 Fax: +91-40-27193189 Email: [email protected], [email protected] OBJECTIVE To pursue Postdoctoral position in the area of synthetic organic and medicinal chemistry such as multidisciplinary drug discovery, drugs based on molecular mechanism, prodrugs, selective cancer chemotherapy. EDUCATIONAL BACKGROUND  Ph. D., (Organic/Medicinal Chemistry) Indian Institute of Chemical Technology (IICT), Hyderabad, India. (2004 till to date) Research work towards the “Design and synthesis of new molecules based on thiolactomycin as potential antitubercular, antimalarial agents and new synthetic approaches for the precursors of biologically active compounds” (Thesis has been submitted to Acharya Nagarjuna University, Guntur, India) Research Supervisor: Dr. Ahmed Kamal, Director Grade Scientist, IICT, Hyderabad, India  M. Sc., (Organic Chemistry) Andhra University, Visakhapatnam, India (2003, First Division)  B. Sc., (Chemistry, Physics, Maths) Acharya Nagarjuna University, Guntur, India (2001, First Division)  Intermediate (Chemistry, Physics, Maths) Board of Intermediate, Hyderabad, India (1998, First Division)

PERSONAL PROFILE  Male, Indian, born on July 24th, 1981 RESEARCH EXPERIENCE Four plus years of research training under the guidance of Dr. Ahmed Kamal, an eminent scientist in the Division of Organic Chemistry at IICT, Hyderabad, India.  Based on SAR studies of thiolactomycin, Design and synthesized more than 30 novel quinolino substituted analogues of thiolactomycin as potential antitubercular agents  Keeping pace on Drug Resistance (MDR and XDR TB) synthesized a library of sulfonamide linked analogues of thiolactomycin active against tuberculosis and malaria  Synthesized the dimers and conjugates of thiolactone and evaluated against different strains of Plasmodium falciparum.  Synthesized

both

enantiomers

(3S,4R)

and

(3R,4S)

of

3-methoxy-4-

methylaminopyrrolidine a key intermediate for a new quinolone antitumor compound AG-7352, which claiming as a drug candidature.  Synthesized both the enantiomers of (3R,4R) and (3S,4S)dihydroxy pyrrolodine by catalytic and biocatalytic approach which are useful intermediates for the preparation of biologically active Sialyl Lewis X mimetics and novel carbohydrate mimics.  Developed new approaches towards the synthesis of biologically active compounds.  Synthesized many pharmaceutically important compounds like fluoxetine, duloxetine curcumene and curcuphenol with high enantioselectivity.  Lipase mediated resolution of a key intermediate of thiolactomycin has been developed and configuration was also assigned.

PROJECTS HANDLED  Involved as a key member in the completion of three year collaborative research project between IICT (INDIA) and University of Capetown (South Africa) under Department of Science and Technology Programmed for the “Biocatalytic and combinatorial approaches to novel product based antimalarial and antitubercular agents” (Year 2004-2007). AWARDS AND HONORS  Qualified Council of Scientific and Industrial Research (CSIR) examination at the national level for Junior Research Fellowships (Dec. 2003).  Qualified Council of Scientific and Industrial Research (CSIR) a Senior Research Fellowship (Aug. 2006). PROFESSIONAL AND PERSONAL STRENGTHS  Synthesis of library of compounds based on SAR studies  Synthesis of biologically active natural and synthetic products  Design of new drugs based on modification of the drugs that are being known  Study of structure activity relation ship of a new compound  Familiar with mechanism of action of known drugs  Familiar with pharmacology  Acquaintance with biological properties of known and recent drugs  Acquaintance with process of biological evaluation  Development of new and safe methods for the synthesis of pharmaceutically important compounds  Acquaintance with most of experimental techniques and safe hands on instruments like HPLC and GC  Interpretation of the structures using 1H NMR, 13C NMR, IR, and various mass spectrometric data  Capable of both collaborative and independent research  Maintain good interpersonal relationships and excellent communication skills

 Knowledge of computers: MS office, Database management packages, Chemoffice, preparation of research reports, review articles, manuscripts for publications. PRESENTATION AT SYMPOSIA  International symposium on “Advanced in organic chemistry”, January 2-6, 2006 Kottayam, India  International symposium on “green/sustainable chemistry”, January 9-15, 2006, at New Delhi, India  National conference on “National symposium on current trends in chemistry” January 30-31, 2007, at Kalyani, West Bengal, India

LIST OF PUBLICATIONS

1. Publications in Medicinal Chemistry 1. A combinatorial approach for the synthesis of new molecules based on thiolactomycin active against tuberculosis and malaria Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik Commucnicated 2008 (J. Comb. Chem.) 2. Synthesis and biological evaluation of thiolactone based analogues as potential antimalarial agents Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik Communicated 2008 to (Eur. J. Med. Chem.) 3. Efforts towards the development of new antitubercular agents: Potential for thiolactomycin based compounds Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik and Maddamsetty. V. Rao J. Pharm. Pharmaceut. Sci. 2008, 11, 56s-80s. Dedicated in memory of Ronald G. Micetisch

2.

Publications in Organic Chemistry 1. Enantioselective synthesis of (3R,4R)- and (3S,4S)-dihydroxy pyrrolidine by catalytic and biocatalytic approach Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik, Ahmad Ali Shaik and Shaikh Faazil S. Rahim Communicated to (Tetrahedron: Asymmetry) 2. Lipase mediated resolution of γ-azidoalcohols in aqueous and organic media: Synthesis of (R)-and (S)-fluoxetine and duloxetine Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza J. Mol. Cat. B: Enzyme (Accepted) 3. Synthesis of enantiomerically pure γ-azidoalcohols by lipase-catalyzed transesterification Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza Tetrahedron: Asymmetry 2008, 19, 1078-1083. 4. Enantioselective synthesis of (R)- and (S)-curcumene and curcuphenol: an efficient chemoenzymatic route Ahmed Kamal, M. Shaheer Malik, Ahmad Ali Shaik and Shaik Azeeza Tetrahedron: Asymmetry 2007, 18, 2547-2553. 5. Chemoenzymatic

synthesis

of

(3R,4S)-

and

(3S,4R)-3-methoxy-4-

methylaminopyrrolidine Ahmed Kamal, Ahmad Ali Shaik, Mahendra Sandbhor, M. Shaheer Malik and Shaik Azeeza Tetrahedron: Asymmetry 2006, 17, 2876-2883. 6. Chemoenzymatic synthesis of (5S)- and (5R)-hydroxymethyl-3,5-dimethyl-4(methoxymethoxy)-5H-thiophen-2-one: a precursor of thiolactomycin and determination of its absolute configuration Ahmed Kamal, Ahmad Ali Shaik, Shaik Azeeza, M. Shaheer Malik and Mahendra Sandbhor

Tetrahedron: Asymmetry 2006, 17, 2890-2895.

List of reviews 7. Approaches based on enzyme mediated kinetic to dynamic kinetic resolutions: A versatile route for chiral intermediates Ahmed Kamal, M. Ameruddin Azhar, Tadiparthi Krishnaji, M. Shaheer Malik and Shaik Azeeza Coord. Chem. Rev. 2008, 252, 569-592. Book 1.

Breadth and importance of acid-base catalysis in green chemistry Ahmed Kamal, Shaik Azeeza, M. Shaheer Malik A chapter for a handbook of green chemistry (Oxford university press). Edited by Bill Nelson in 2008

REFERENCES 1. Dr. Ahmed Kamal, Director Grade Scientist Chemical Biology Division of Organic Chemistry-I Indian Institute of Chemical Technology Hyderabad-500 607, A.P. INDIA Phone: +91-40-27193157 (Off), +91-40-23319370 (Res) Fax: +91-40-27193189 E-mail: [email protected] 2. Dr. M. Venkateswara Rao Scientist Division of Organic Chemistry-I Indian Institute of Chemical Technology Hyderabad-500 607, A.P. INDIA

Phone: +91-40-27160123 Extn 1635 (Off) E-mail: [email protected]