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[SP722] LONG-TERM RESULTS OF RENAL TRANSPLANTATION: A SINGLE CENTER ANALYSIS OF 1200 TRANSPLANTS Alireza Mehdizadeh, Afsoon Fazelzadeh, Heshmatollah Salahi, Jamshid Rouzbeh, Seyed Ali MalekHosseini. Southern Iran Transplant Center, Nemazee Hopspital, Shiraz, Fars, Iran. INTRODUCTION AND AIMS: Renal transplantation is now considered the best therapeutic option for chronic renal failure. It was carried out for the first time ever in Iran in 1963, in Southern city of Shiraz, Nemazee Hospital. The process accelerated after establishment of Shiraz (Southern Iran) Organ Transplant Center in 1988; as a leading center for organ transplantation and as the only center for liver transplantation in Iran. The present study is a report of long-term results of the first 1200 operations performed in this center. METHODS: This retrospective study included all kidney transplanted patients who were operated in Shiraz Organ Transplant Center since Dec. 1988 till Dec. 2003. Patients files in addition to Persian Network for Organ Transplant (PNOT) were used as sources of data. The immunosuppressive protocol and general procedures used in our transplant unit are nearly the same for all patients and have been described previously. [1] Regular indefinite follow-up was considered uniformly for all patients. Graft loss was defined as nephrectomy, return to dialysis, or death with a functioning graft. The diagnosis of acute rejection was made by clinical rising of serum BUN and creatinine and also confirmed by biopsy. Graft and patient survival rates in eligible cases were computed with the Kaplan-Meier analysis. RESULTS: Recipients were 808 males, 392 females; mean age was 33.6 12.5 years. 86% of cases used organs from living donors (40% related, 41% unrelated, and 5% spouses) and 14% from cadaveric source. Most Common causes of end-stage renal disease were chronic glomerulonephritis (18.2%), reflux nephropathy (13.4%), and diabetic nephropathy (10.1%). In 215 (17.9%) patients; 156 patients (13%) died in the posttransplant period. Most common causes of death were cardiovascular (28.3%), graft loss (20.7%) and infections (19.6%). The 1 and 3 year patient survival rates were 94% and 91.5%; and graft survival rates were 88% and 84%. CONCLUSIONS: Although the success rate of operations has not been so satisfactory at the beginning, the current data reflecting a survival rate of >90% is comparable to major centers throughout the world. Sunday, July 16, 2006 Poster: Transplantation - Experimental
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file:///J|/print/glascow/view722.php.htm2006/09/25 09:32:45 Þ.Ù
[SP722] LONG-TERM RESULTS OF RENAL TRANSPLANTATION: A SINGLE CENTER ANALYSIS OF 1200 TRANSPLANTS Alireza Mehdizadeh, Afsoon Fazelzadeh, Heshmatollah Salahi, Jamshid Rouzbeh, Seyed Ali MalekHosseini. Southern Iran Transplant Center, Nemazee Hopspital, Shiraz, Fars, Iran. INTRODUCTION AND AIMS: Renal transplantation is now considered the best therapeutic option for chronic renal failure. It was carried out for the first time ever in Iran in 1963, in Southern city of Shiraz, Nemazee Hospital. The process accelerated after establishment of Shiraz (Southern Iran) Organ Transplant Center in 1988; as a leading center for organ transplantation and as the only center for liver transplantation in Iran. The present study is a report of long-term results of the first 1200 operations performed in this center. METHODS: This retrospective study included all kidney transplanted patients who were operated in Shiraz Organ Transplant Center since Dec. 1988 till Dec. 2003. Patients files in addition to Persian Network for Organ Transplant (PNOT) were used as sources of data. The immunosuppressive protocol and general procedures used in our transplant unit are nearly the same for all patients and have been described previously. [1] Regular indefinite follow-up was considered uniformly for all patients. Graft loss was defined as nephrectomy, return to dialysis, or death with a functioning graft. The diagnosis of acute rejection was made by clinical rising of serum BUN and creatinine and also confirmed by biopsy. Graft and patient survival rates in eligible cases were computed with the Kaplan-Meier analysis. RESULTS: Recipients were 808 males, 392 females; mean age was 33.6 12.5 years. 86% of cases used organs from living donors (40% related, 41% unrelated, and 5% spouses) and 14% from cadaveric source. Most Common causes of end-stage renal disease were chronic glomerulonephritis (18.2%), reflux nephropathy (13.4%), and diabetic nephropathy (10.1%). In 215 (17.9%) patients; 156 patients (13%) died in the posttransplant period. Most common causes of death were cardiovascular (28.3%), graft loss (20.7%) and infections (19.6%). The 1 and 3 year patient survival rates were 94% and 91.5%; and graft survival rates were 88% and 84%. CONCLUSIONS: Although the success rate of operations has not been so satisfactory at the beginning, the current data reflecting a survival rate of >90% is comparable to major centers throughout the world. Sunday, July 16, 2006 Poster: Transplantation - Experimental
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file:///J|/print/glascow/view722.php.htm2006/09/25 09:32:45 Þ.Ù
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