Psychosis Figures

  • November 2019
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Substantia Nigra

/D

3

D2

Ventral Tegmental Area D2

Mean % Improvement at follow up

Dopaminergic System

striatum

autoreceptors

mesocortical

mesolimbic

EPS D1

49

50 45

41

39

40 30

30

20

20 12

5 19 90

19 80

19 70

19 60

19 50

19 40

19 30

19 20

<1 91 0

0

Decade

Stress-Diathesis Model Vulnerability

stre

D3

Nucleus accumbens

negative symptoms

positive symptoms

Biological Model: Dopaminergic Mechanism

10

10

neurodevelopmental

/ D2

thalamus dm

5HT

25

25 15

Raphe tegmental

35

35

frontal lobe (dlpfc)

Clinical Schizophrenia

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