Substantia Nigra
/D
3
D2
Ventral Tegmental Area D2
Mean % Improvement at follow up
Dopaminergic System
striatum
autoreceptors
mesocortical
mesolimbic
EPS D1
49
50 45
41
39
40 30
30
20
20 12
5 19 90
19 80
19 70
19 60
19 50
19 40
19 30
19 20
<1 91 0
0
Decade
Stress-Diathesis Model Vulnerability
stre
D3
Nucleus accumbens
negative symptoms
positive symptoms
Biological Model: Dopaminergic Mechanism
10
10
neurodevelopmental
/ D2
thalamus dm
5HT
25
25 15
Raphe tegmental
35
35
frontal lobe (dlpfc)
Clinical Schizophrenia