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9.0
Pentose Phosphate Pathway
The Pentose Phosphate Pathway produces reducing power in the form of NADPH that the cell can use to fuel biosynthetic reactions and produce a number of other sugars. The three, four, five, six, and seven carbon sugars produced by the pentose phosphate pathway can enter a number of biosynthetic or oxidative pathways. Glycolytic intermediates such as glyceraldehyde 3-phosphate can be used to produce ATP while other sugars such as ribose 5-phosphate can be used to synthesize nucleotides. Click the enzyme or substrate labels for more information.
9.10 Glucose 6-Phosphate Dehydrogenase Glucose 6-Phosphate Dehydrogenase converts glucose 6-phosphate to 6-phosphogluconolactone while reducing NADP+ to NADPH.
9.20 6-Phosphoglucolactonase 6-Phosphoglucolatonase hydrates 6-phosphogluconolactone, converting it to 6-phosphogluconate.
9.30 6-Phosphogluconate Dehydrogenase 6-Phosphogluconate Dehydrogenase converts 6-phosphogluconate to ribulose 5-phosphate and CO2 while reducing NADP+ to NADPH.
9.40 Ribose 5-Phosphate Isomerase Ribose 5-Phosphate Isomerase reversibly converts ribulose 5-phosphate to ribose 5-phosphate.
9.50 Phosphopentose Epimerase Phosphopentose Epimerase reversibly converts ribulose 5-phosphate to xylulose 5-phosphate.
9.60 Transketolase Transketolase reversibly converts xylulose 5-phosphate and ribose 5-phosphate to sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. Transketolase can also reversibly convert erythrose 4-phosphate and xylulose 5-phosphate to fructose 6-phosphate and glyceraldehyde 3-phosphate.
9.70 Transaldolase Transaldolase reversibly converts glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to fructose 6-phosphate and erythrose 4-phosphate
9.70.1
NADPH
NADPH is a reducing equivalent that is produced in the pentose phosphate pathway. It is not used for energy production but serves as reducing power for biosynthetic reactions and to reduce oxidized macromolecules. NADPH levels are independent of NADH levels.
Pentose Phosphate Pathway
The Pentose Phosphate Pathway produces reducing power in the form of NADPH that the cell can use to fuel biosynthetic reactions and produce a number of other sugars. The three, four, five, six, and seven carbon sugars produced by the pentose phosphate pathway can enter a number of biosynthetic or oxidative pathways. Glycolytic intermediates such as glyceraldehyde 3-phosphate can be used to produce ATP while other sugars such as ribose 5-phosphate can be used to synthesize nucleotides. Click the enzyme or substrate labels for more information.
9.10 Glucose 6-Phosphate Dehydrogenase Glucose 6-Phosphate Dehydrogenase converts glucose 6-phosphate to 6-phosphogluconolactone while reducing NADP+ to NADPH.
9.20 6-Phosphoglucolactonase 6-Phosphoglucolatonase hydrates 6-phosphogluconolactone, converting it to 6-phosphogluconate.
9.30 6-Phosphogluconate Dehydrogenase 6-Phosphogluconate Dehydrogenase converts 6-phosphogluconate to ribulose 5-phosphate and CO2 while reducing NADP+ to NADPH.
9.40 Ribose 5-Phosphate Isomerase Ribose 5-Phosphate Isomerase reversibly converts ribulose 5-phosphate to ribose 5-phosphate.
9.50 Phosphopentose Epimerase Phosphopentose Epimerase reversibly converts ribulose 5-phosphate to xylulose 5-phosphate.
9.60 Transketolase Transketolase reversibly converts xylulose 5-phosphate and ribose 5-phosphate to sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. Transketolase can also reversibly convert erythrose 4-phosphate and xylulose 5-phosphate to fructose 6-phosphate and glyceraldehyde 3-phosphate.
9.70 Transaldolase Transaldolase reversibly converts glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate to fructose 6-phosphate and erythrose 4-phosphate
9.70.1
NADPH
NADPH is a reducing equivalent that is produced in the pentose phosphate pathway. It is not used for energy production but serves as reducing power for biosynthetic reactions and to reduce oxidized macromolecules. NADPH levels are independent of NADH levels.
