Plavix Clopidogrel

NURS 1566 Clinical Form 3: Clinical Medications Worksheets (You will need to make additional copies of these forms) Generic Name Trade Name clopidogrel Plavix Peak 3-7 days

Onset within 24 hr

Classification antiplatelet agents

Duration 5 days

Dose 75 mg tab

Route PO

Time/frequency Q day

Normal dosage range 75mg once daily

Why is your patient getting this medication Reduce risk of stroke

For IV meds, compatibility with IV drips and/or solutions N/A

Mechanism of action and indications (Why med ordered) Inhibits platelet aggregation by irreversibly inhibiting the binding of ATP to platelet receptors

Nursing Implications (what to focus on) Contraindications/warnings/interactions Hypersensitivity, pathologic bleeding (peptic ulcer, intracranial hemorrhage), patients at risk for bleeding (trauma, surgery, or other pathologic conditions), history of GI bleeding/ulcer disease Common side effects No common side effects Potential life threatening side effects: GI BLEEDING, BLEEDING, NEUTROPENIA, THROMBOTIC THROMBOCYTPENIC PURPURA

Interactions with other patient drugs, OTC or herbal medicines (ask patient specifically) Lovenox (may increase the risk of bleeding)

Nursing Process- Assessment (Pre-administration assessment) History and physical, assess risk for blood clots

Lab value alterations caused by medicine Monitor bleeding time during therapy. Prolonged bleeding time, which is time- and dose-dependent, is expected Monitor CBC with differential and platelet count periodically during therapy. Neutropenia and thrombocytopenia may rarely occur. May cause ↑ serum bilirubin, hepatic enzymes, total cholesterol, nonprotein nitrogen (NPN), and uric acid concentrations. Be sure to teach the patient the following about this medication Avoid taking OTC medications containing aspirin or NSAIDs without consulting health care professional. Assessment Evaluation Why would you hold or not give this Check after giving med? Successful prevention of Fever, chills, sore throat, or unusual stroke bleeding or bruising occurs