Perhitungan Dosis.docx

Perhitungan Dosis Dosis: 4dd 500-750mg p.c (OOP ed.6 hlm. 86) Dosis Dewasa 500mg/ 1x 500𝑚𝑔 𝑥

=

500𝑚𝑔 5𝑚𝐿 500𝑚𝑔. 5𝑚𝐿

x

=

x

= 5mL

1x

= 5mL

500𝑚𝑔

Jadi, dosis untuk dewasa = 4 x sehari 5mL Kadar 500mg/5mL 500𝑚𝑔 𝑥

𝑥 𝑚𝑔

= 60𝑚𝐿 500𝑚𝑔. 60𝑚𝐿

x

=

x

= 600mg

5 𝑚𝐿

= 6g 6𝑔 60𝑚𝐿

.100% = 10%

PENDEKATAN FORMULA No.

Nama Bahan

Jumlah

Kegunaan

1.

Klorampenikol Palmitat

10%

b/v Bahan aktif (FI V hlm. 690)

2.

HPMC

2,5%

b/v Suspending agent (HOPE, 6th ed. p. 326)

3.

Natrium Sakarin

0,2%

b/v Sweetening agent (HOPE, 6th ed. p. 608)

4.

Sirupus Simplex

25%

b/v Sweetening agent (HOPE 6th ed. p. 703)

5.

Propilen Glikol

10%

b/v Wetting agent, Pelarut Pengawet (HOPE 6th ed. p. 592)

6.

Methylparaben

0,015% b/v Pengawet (HOPE 6th ed. p. 441)

7.

Prophylparaben

0,01%

8.

Asam Phospat

0,248% b/v Dapar (FI V hlm. 1727)

b/v Pengawet (HOPE 6th ed. p. 596)

(KH2PO4) 9.

Garam Phospat

0,75%

b/v Dapar (FI V hlm. 1727)

(NaH2PO4) 10.

HCl 0,1N/NaOH 0,1N

qs

Adjust pH

11.

Oleum Aurantii

qs

Flavouring agent (Martindale 36 p. 2357)

I.

12.

Pasta Jeruk

13.

Aquadest

qs

Colouring agent

ad 100% v/v Pelarut (HOPE 6th ed. p. 766 )

PENIMBANGAN › Dibuat sediaan 4 botol (@60ml)

60mL x 4 botol

= 240mL

240mL + (2% x 240mL)

= 240mL + 4,8mL = 244,8mL

244,8mL + (10% x 244,8mL)

= 244,8mL + 24,48mL = 269,28mL ~ 280mL

No.

Nama Bahan

1.

Klorampenikol Palmitat

2.

HPMC

3.

Natrium Sakarin

4.

Sirupus Simplex

5.

Propilen Glikol

6.

Methylparaben

Jumlah yang Ditimbang 10 g . 280mL = 28g 100mL 2,5g . 280mL = 7g 100mL 0,2g . 280mL = 0,56g 100mL 25 g . 280mL = 70g 100mL 10 g . 280mL = 14g 100mL 0,015 g . 280mL = 0,042g 100mL

0,01 g . 280mL = 0,028g 100mL 0,2408 g . 280mL = 0,674g 100mL 0,75 g . 280mL = 2,1g 100mL

7.

Prophylparaben

8.

Asam Phospat (KH2PO4)

9.

Garam Phospat (NaH2PO4)

10.

HCl Pekat

2 tetes

11.

Oleum Aurantii

2 tetes

12.

Pasta Jeruk

10 tetes

13.

Aquadest

ad 280mL