Pathophysiology Of Osteomyelitis(diagram)

Predisposing factors: vascular insufficiency disorders genitourinary infections respiratory infections IV drug use immunocompromising diseases history of blood- stream infections Indwelling prosthetic devices

Open wounds/ fractures Microorganisms gain entry by way of blood Microorganisms lodge into an area where circulation slows Microorganisms grow Increase pressure

Ischemia

fever, night sweats, chills, restlessness, nausea and malaise constant bone pain, swelling, tenderness, warmth at the infection site, restricted movement of the affected part

Vascular compromise of the periosteum Infection through the bone cortex and marrow Cortical devascularization necrosis

Debridement

Formation of new bone

Separation of devitalized bone from living bone

Involcrum

Sequestra

Continues to be an infected island Difficulty to reach by blood borne antibiotics Enlarged sequestrum

Chronic stage

drainage from sinus tracts

Systemic signs may be diminished with constant bone pain, Swelling, tenderness, warmth at the infection site

Sequestrum move out to the soft tissue

Development of sinus tract Turns to scar tissue

revascularized

Site for continued microorganism growth

Removal by the normal immune process

Remission and exacerbation

Healing

Excessive vascular insufficiency Loss of organ function

Amputation