Path O Physio 123

* Escherichia Coli *Enterococuss Faecalis *Kleibshiella *Pseudomonas Aeruginosa

PATHOPHYSIOLOGY (Bacterial infection) Ascends to the Kidney Infection at : Renal Pelvis, Tubules and Interstitial Tissues of one or both Kidney Release of Inflammatory Chemical Mediators _ Chemotaxis Attraction of Leukocytes

Increased blood flow Increase blood cell Delivery

Host cell produces

Increase capillary Permeability

Release of cytokines

Fluid Shift Production of Swelling

leukocytes

Pain on lumbar

Dysuria

area & abdomen

endogenous pyrogens Diapedesis Phagocytosis Accelerates set point hypothalmic

Vasoconstriction

Leukocytosis of

Pus

thermo regulatory center

Pressure on nerves

Abscess Pyuria Stimulation of visceral afferent pathway

Stimulation of medullary vomiting center Fever Nausea

Vasodilation

Increased

metabolism Vomiting Oxygen demand

Increased Cerebral vasodilation

Flushed skin

Poor appetite Increase HR

Headache

Malaise Weight loss

Increase RR Increase vapor loss

Fatigue Dehydration Excessive thirst Polyuria

CHRONIC PYELONEPHRITIS Persistent recurring infection Progressive scarring of kidney Renal failure Septic shock