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How to order metronidazole without prescription? I usually use online dragstores. Metronidazole rapidly is sucked (80% during not less than 1 hour). The maximum concentrations in the serum, obtained after oral introduction, are analogous to the same after the intravenous drop infusion of equivalent doses. The maximum concentration in the serum, the component of 10 g/ml inward approximately after 1 hour is reached after the single method 500 mH of preparation. It substantially does not change with the simultaneous consumption of food. Period of half-life in the plasma 8-10 h. The binding of Metronidazole with the proteins of the blood weak - is less than 10 20%. Volume of distribution - about 40 l. Metronidazole rapidly penetrates the lungs, the kidneys, the liver, the skin, the bile, the cerebro-spinal fluid, the saliva, the seed liquid, the vaginal secrets; it penetrates through the placental barrier and the breast milk. Metabolism occurs in the liver. By oxidation are formed two metabolites: alcohol metabolite with the bactericidal activity with respect to anaerobic microorganisms of about 30% of the activity of Metronidazole and the period of half-life of approximately 11 h and the acid metabolite, which possesses bactericidal activity of about 5% of the activity of Metronidazole.
Metronidazole is accumulated mainly in the liver and the bile. It is derived with the urine (40-70%, of them 20% in the constant form), in this case the urine acquires red-brown colored. The period of half-life does not change with the kidney deficiency and therefore the correction of dosage is optional. With hemodialysis Metronidazole rapidly is derived, the period of half-life decreases to 2 h of 30 min.