Observation And Result
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OBSERVATION AND RESULTS
The study entitled “Effect of panchatikta Taila Matra Basti in the patients suffering from Katishula vis-a vis Lumbar Spondylosis.” was planned to evaluate effect of Panchatikta Taila on the patient of Katishula. For that Panchatikta Taila Matra Basti along with Madhu was given to one group comprising 20 patients of Katishula for 9 days. This group of treatment was termed as Group A. To compare the effect of Madhu in Matra Basti, another group comprising 20 patients of Katishula was given Panchatikta Taila Matra Basti for 9 days. This group was termed as Group B. Prior to start of the study in both groups, patients selected for study were closely observed for a period of two days. In this period of observation detailed history of patients was evaluated as per Performa of case record form mentioned in the ending of materials and methods. In these two days, all investigations were carried out and these values were termed as before treatment. As well as the status of the patient was also recorded with respect to symptoms and signs found in the patient of Katishula of this series. After completion of duration all the required investigations of all the patients from both groups were again done. All these values were recorded and termed as after treatment values. The status of all the symptoms and signs were also recorded after completion of treatment.
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Thus the change in the status of symptoms, signs and investigations were recorded. The history recorded in this study on case record form, revealed the facts and findings, which are presented herewith in the tabular form. Some of them are highlighted with the help of graphical presentations. TABLE-9 Table Showing Age-wise distribution of 40 patients of KATISHULA Sr. Age Group No.
Group A
Group B
No. of pts.
%
No. of pts
%
1)
00
00
00
00
00
09
45
10
50
19
47.5
Praudhavasta 11
55
10
50
21
52.5
Balyavasta
Total No. Percentage Patients
(0-16yrs.) 2)
Tarunavasta (17-40yrs.)
3)
(41-60 yrs.)
.
Ayurvedic concept of age is somewhat different with respect to
modern science.Age group as described by Sharangdhara was considered in this study. In the present study maximum number of patients (52.5%) were from the praudha-Avastha of Age while, 47.5% patients were from taruna avasta (Table 9).
94
TABLE-10 Table Showing Sex-wise distribution of 40 patients of KATISHULA Sr. Sex No.
Group A
Group B
Total No. Percentage Patients
No. of pts.
%
No. of pts
%
1)
Male
6
30
8
40
14
35
2)
Female
14
70
12
60
26
65
Table-10 reveals that maximum numbers of patients (65%) were female whereas 35% of patients were male. TABLE-11 Table Showing Religion -wise distribution of 40 patients of KATISHULA Sr. Religion No.
Group A
Group B
No. of pts.
%
No. of pts
%
1)
Hindu
19
95
18
90
37
92.5
2)
Muslim
01
05
00
00
1
2.5
3)
Christian
00
00
02
10
2
5.0
94
Total No. Percentage Patients
Table-11 data reveals that maximum number of patients (92.5%) were from Hindu religion, followed by 5% from Christian religion whereas 2.5% from Muslim religion.
TABLE-12 Table Showing Economical status of 40 patients of KATISHULA Sr. Economical No. status
Group A
Group B
Total No. Percentage Patients
No. of pts.
%
No. of pts
%
1)
Poor
02
10
01
05
03
7.5
2)
Middle class
18
90
18
90
36
90
3)
Rich
00
00
01
05
01
2.5
90% of patients in Group A and 90% of Group B were found to be Middle-class income group. However 10% from Group Aand 5% from Group B were found to be Lower class group. While only 5% of higher class noted from Group B. (Table 12) TABLE-13 Table Showing Educational status of 40 patients of KATISHULA Sr. Educational No. status
Group A No.
Group B
%
No.
94
%
Total No. Patients
Percentage
of pts.
of pts
1)
Uneducated
01
05
03
15
04
10
2)
Educated up to SSC
09
45
07
35
16
40
3)
HSC
04
20
03
15
7
17.5
4)
Graduate
06
30
07
35
13
32.5
In this series 05% people from Group A and15% from Group B were found to be uneducated. Remaining patients were educated up to different level of education. In that 45% in Group A and 35% in Group B were found to be educated up to HSC. While 30% in Group A and 35% in Group B, were found to be graduate people. TABLE-14 Table Showing Chronicity of disease of 40 patients of KATISHULA Group A Sr. No.
Chronicity of disease
No. of pts.
1)
0-1 yrs
2)
Group B %
Total No. Patients
Percentage
08
40
17
42.5
30
07
35
13
32.5
04
20
04
20
08
20
01
5
01
5
02
5
%
No. of pts
09
45
1-5 yrs
06
3)
5-10 yrs
4)
<10 yrs
In this maximum patient (42.5%) have symptoms since last 1year back.32.5%have same symptom since 5 years.20% patients
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have same complaint since 10 years and rest 5% since more than 10 years.
TABLE-15 Table Showing Marital status of 40 patients of KATISHULA
Sr. No.
Group A Family History
Group B
No. of pts.
%
No. of pts
%
Total No. Patients
Percentage
1)
Unmarried
01
05
00
00
01
2.5
2)
Married
18
90
19
95
37
92.5
3)
Widow
01
05
01
05
02
05
4)
Widower
00
00
00
00
00
00
In above table only 5% were unmarried, maximum i.e.90% in Group A and 95% in Group B were married. Only 5% were widow in each group TABLE-16 Table Showing Dominant Rasa in Ahar of 40 patients of KATISHULA
95
Sr. No.
Dominant Rasa in Ahar
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Madhur
12
60
10
50
22
55
2)
Amla
12
60
15
75
27
67.5
3)
Lavan
05
25
08
40
13
32.5
4)
Katu
19
95
18
90
37
92.5
5)
Tikta
08
40
08
40
16
40
6)
Kashaya
03
15
01
05
04
10
Ayurveda bestowed the importance of diet having all six types of Rasa.Most of the Ayurvedic physicians of ancient era opined that the diet having six types of Rasa should be ingested. People may have the habit of consuming one or two particular Rasas excessively and then may produce diseases related to it. It was revealed that 95%of peoples in Group As and 90% Group B were having the habit of ingesting food having Katu rasa. Some of them had having habit of taking excess Madhura and Amla Rasa, they were 60% in Group A and 50% and 75% in Group B. Incidance of Tikta,Kashay and Lavana rasa also noted as shown in the table 16. TABLE-17 Table Showing Type of Food Ingested by of 40 patients of KATISHULA Sr.
Type of
Group A
Group B
94
Total
No. Percentage
No.
Patients Food Ingested
No. of pts.
%
No. of pts
%
1)
Vegetarian
06
30
08
40
14
35
3)
Mixed
14
70
12
60
26
65
The above table shows that more patients were having mixed diet (70% in Group A and 60% in group B).Rest of having Vegetarian diet (30% in Group A and 40% in group B). TABLE-18 Table showing dominant Guna in ahara by 40 patients of KATISHULA Sr. No.
Dominant Guna in Ahar
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Ushna
06
30
07
35
13
32.5
2)
Shita
14
70
13
65
27
67.5
3)
Laghu
14
70
12
60
26
65
4)
Guru
06
30
08
40
14
35
5)
Snigdha
08
40
09
45
17
42.5
6)
Ruksha
12
60
11
55
23
57.5
7)
Veg.oil
20
100
20
100
40
100
8)
Ghee
03
15
05
25
08
20
94
In this study, maximum patients were taking shita and Laghu guna pradhan ahara. All patients were used veg.oil in their ahara. TABLE-19 Table Showing Vyasana of 40 patients of KATISHULA Sr. No.
Vyasana
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Madyapana
01
05
02
10
03
7.5
2)
Tobacco
05
25
07
35
12
30
3)
Tea/Coffee
19
95
20
100
39
97.5
4)
Smoking
01
05
03
15
04
10
5)
None
01
05
00
00
01
2.5
In this study, maximum patients were addicted to bad habit. It shows maximum patient was addicted to Tea or Coffee. Tobacco chewing was next to it with 25% in Group A and 35% in Group B. Smoking and Madyapana were 05% in Group A and 15%, 10% in Group B respectively. TABLE-20 Table Showing Type of Work done by 40 patients of KATISHULA Sr.
Type of
Group A
Group B
94
Total No.
Percentage
No.
Work
No. of pts.
%
No. of pts
%
1)
Sedentary
06
30
08
40
14
35
2)
Standing
03
15
03
15
06
15
3)
Sitting
04
20
02
10
06
15
4)
Labor
07
35
07
35
14
35
Patients
The type of work done by the patient is also as important as Aahar concept narrated by the Acharya Charak. Therefore the history of work done by patients was pinpointed. It is observed that the standing type of work done by patients of Katishula in the both groups was 15% and the sitting type of work done by the patient’s was 20% in Group A and 10% in Group B as shown in the table 20. The maximum patients 35% in the both groups was found to be laborious worker. In the above study 30% in Group A and 40% in Group B of patients having sedentary type of work TABLE-21 Table showing Sara Parikshana by 40 patients of KATISHULA Sr. No.
Group A Sara Parikshana
No. of pts.
%
Group B No. of pts
94
%
Total No. Percentage Patients
1)
Avara
06
30
05
25
11
27.5
2)
Madhyam
11
55
12
60
23
57.5
3)
Pravara
03
15
03
15
06
15
In this study, maximum patients were Madhyam Sara (57.5%). Only 15% patient’s were Pravara Sara as shown in table. TABLE-22 Table Showing Doshaj Prakriti in 40 patients of KATISHULA Group A Sr. No.
Doshaj Prakriti
No. of pts.
1)
Vata-Pittaja
2) 3)
Group B %
Total No. Patients
Percentage
10
50
19
42.5
15
04
20
07
17.5
40
06
30
14
35
%
No. of pts
09
45
Pitta-Kaphaja
03
Kapha-Vataja
08
Prakruti parikshan is the basic concept of Ayurved and it has much more importance in Chikitsa.In above table 45% of Group A and 50% of Group B constituted Vata-Pittaja type Prakriti.The incidence for Pitta-Kaphaja was 15% and 20% patients of Group A and Group B respectively. 40% and 30% patients of Group A and Group B respectively in Kapha-Vataja type of Prakriti. TABLE-23
94
Table Showing Samhanana of 40 patients of KATISHULA Group A Sr. Samhanana No.
No. of pts.
Group B
%
No. of pts
%
Total No. Patients
Percentage
1)
Avar
05
25
06
30
11
27.5
2)
Madhyam
11
55
11
55
22
55
3)
Pravara
04
20
03
15
07
17.5
TABLE-24 Table Showing Satva-Bala of 40 patients of KATISHULA Group A Sr. No.
Satva-Bala
No. of pts.
1)
Avar
2) 3)
Group B %
Total No. Patients
Percentage
05
25
11
27.5
55
12
60
23
57.5
15
03
15
06
15
%
No. of pts
06
30
Madhyam
11
Pravara
03
TABLE-25 Table Showing Vyayama Shakti Parikshana of 40 patients of KATISHULA
94
Group A Sr. No.
Vyayama Shakti
No. of pts.
1)
Avar
2) 3)
Group B %
Total No. Patients
Percentage
03
15
07
17.5
55
11
55
22
55
25
06
30
11
27.5
%
No. of pts
04
20
Madhyam
11
Pravara
05
TABLE-26 Table Showing Akrititaha Parikshana of 40 patients of KATISHULA Group A Sr. No.
Akriti
No. of pts.
1)
Krisha
2) 3)
Group B %
Total No. Patients
Percentage
08
40
15
37.5
50
09
45
19
47.5
15
03
15
06
15
%
No. of pts
07
35
Madhyam
10
Sthula
03
TABLE-27 Table Showing Deshatah Parikshana of 40 patients of KATISHULA Group A Sr. No.
Deshatah
No. of pts.
1)
Anupa
2) 3)
Group B %
Total No. Patients
Percentage
08
40
18
45.5
30
07
35
13
32.5
20
05
25
09
%
No. of pts
10
50
Jangla
06
Sadharana
04
94
22.5
TABLE-28 Table Showing Ahar-Shakti Parikshana of 40 patients of KATISHULA Group A Sr. No. A)
Ahar-Shakti
No. of pts.
Group B
%
No. of pts
%
Total No. Patients
Percentage
Abhyavaharana Shakti
1)
Avar
04
20
03
15
07
17.5
2)
Madhyam
14
70
12
60
26
65
3)
Pravara
02
10
05
25
07
17.5
B)
Jaran-Shakti
1)
Avar
05
25
05
25
10
25
2)
Madhyam
13
65
10
50
23
57.5
3)
Pravara
02
10
05
25
07
17.5
C)
Agni
1)
Visham
08
40
06
30
14
35
2)
Tikshna
03
15
02
10
05
12.5
3)
Manda
02
10
03
15
05
12.5
4)
Madhyam
07
35
09
45
16
40
Dashavidha – Parikshana : All the patients included in this study were examined with respect
to
Ashtavidha,
Dashavidha,
94
Strotasa
etc.
Parikshana.
Dashvidha parikshana such as Prakruti, Sara, etc. help to have the idea regarding of the dominance of Bala, of the patients. In this series Dvandva type of Prakruti was encounted which is mention before. Most of the patients are having Madhyam type of Samhanan (55% of Group A and Group B as per Table- 23). In this study Satva was also investigated. Maximum number patients (about 55 % of Group A and 60%of Group B) having Madhyam type of Satva already shown in Table – 24) Vyamshakti is nothing but the work. A parameter which gives idea about Deha Bala. In the Katishula, Bala of patients which depends on Dhatu-Saratva is reduced. Maximum patients of this series had Madhyam Vyam Shakti(55% in both group), which had been indicated in table-25. Examination of Agni: Examination of status of Agni is one of the important factors, as Proper Agni is essential for the metabolism. Therefore it is at most important to have the idea regarding the status of Agni of patients of Katishula. The patients registered; in this series were investigated with respect to Abyavaran Shakti, Jaran Shakti. It was noted that 70% patients in Group A and 60% in Group B had Madhyam Abhyavaran
95
Shakti, while that of 65% of Group A and 50% of Group B having Madhyam type of Jaran shakti. Also it can be noted that 20% of Group A and 25% of Group B patients having Pravara Abhyavaran shakti and only 10% and 25% respectively having Pravara Jaran shakti. It means that peoples of Katishula were more likely goes towards Mithya-ahar. Examination of Sthulata Krishata exclusively principles of management of Katishula, depends upon Sthulata and Krishata of Patients. In this series 50% patients of treated, and 45% patients of controlled having Madhayam Akruti; Krisha was noted in 35% and 40% patients of Group A and Group B respectively. (Table – 26) About 50% of Group A and 40% of controlled patients was found to be residential of Anupa Desh, 30% and 35% patients of Group A and Group B was found to be residential of Jangala Desh as per shown in Table – 27.
96
TABLE-29 Showing Incidence of main Vyadhi Ghataka involved 40 patients of KATISHULA Sr. No.
Vyadhi Ghatak involved
Group A
Group B
No. of pts.
No. of pts
%
%
Total No. Patients
Percentag e
A) Dosha-Involved 1)
VataDominance
20
100
20
100
40
100
2)
PittaDominance
12
60
09
45
21
52.5
3)
KaphaDominance
04
20
05
25
09
22.5
B) Dhatu-Involved 1)
Rasa Dhatu
06
30
05
15
11
27.5
2)
Rakta Dhatu
11
55
13
65
24
60
3)
Mamsa Dhatu
05
25
03
15
08
20
4)
Meda Dhatu
03
15
04
20
07
17.5
5)
Asthi Dhatu
20
100
20
100
40
100
6)
Majja Dhatu
12
60
11
55
23
57.5
7)
Shukra
00
00
00
00
00
00
98
Dhatu C) Strotas Involved 1)
Rasa-vaha
12
60
10
50
22
55
2)
Rakta-vaha
09
45
09
45
18
45
3)
Mamsa-vaha
05
25
05
25
10
25
4)
Meda-vaha
03
15
03
15
06
15
5)
Asthi-vaha
20
100
20
100
40
100
6)
Majja-vaha
20
100
18
90
38
95
Concept of Vyadhi in Ayurveda is unique, which deals with Dosha, Dushya, Srotas and particular region on the body. Katishula is generalized disease in which whole body is affected.
Incidence for Dosha dushti: Incidence for involvement of Dosha was evaluated with the help of Dosha-Vruddhi Laxanas. In this study 100% of patients in the both groups exhibited dominance of Vata Dushti Laxanas. Dominance of Pitta dushti was found in 60% in Group A and 45% in group B of Katishula, while that Kapha dominance was found to be 20% and 25% in Group A and Group B respectively. (Table 21) Incidence for Dhatu Dushti:
99
In this study it was observed that Asthi Dhatu Dushti was observed in all patients of both the groups. Mamsa Dushti was found in 25% of Group A and 15% of Group B of patients. 55% of Group A and 65% of Group B of patients is found to be Dushti in Rakta Dhatu also. 60% of Group A and 55% of Group B of patients is found to be Majja Dhatu Dushti. Involvement of Srotasa: In this study Asthivaha Srotas were involved in all patients of both the groups.100% and 90% of patients in Group A and Group B was found to be Dushti in Majjavaha Srotas respectively. 45% in Raktavaha Strotas,25% in Mansavaha Strotas and 15% in Medavaha Strotas Dushti were found in both group respectively.
TABLE-30 Table Showing Effect of Symptoms Score of 40 Patients of Katishula
Group A Sr. No. 1
Symptom BT Katishula
46
AT 16
Group B
Differe nce
Percent age of Relief
BT
AT
Differ ence
Percent age of Relief
30
65.21
48
25
23
47.91
94
2 3
Akunchan Prasaranyoh Shula Pidanasahat va
36
10
26
72.22
37
16
21
56.75
38
11
27
71.05
38
16
22
57.89
4
Shulasya Kala
31
11
20
64.51
36
14
22
61.11
5
Anidra
30
5
25
83.33
28
9
19
67.85
Effect of Therapy on symptoms Score: It was observed that overall percentage of relief was more in Group A than Group B. The symptoms such as katishala, Akunchan Prasaranyoh Shula, pidansahatva, shulasya kala, anidra etc. were studied in this series as described in Table
TABLE-31 Table Showing Effect on Symptoms of 20 Patients of Katishula of Group A group by Wilcoxon-Matched –Pairs-Signed-Ranks Test
Sr. no 1
Symptom
Mean
SD
SEd
Sum of All Signed Ranks
Katishula BT AT Diff.
2.3 0.8 1.5
0.4702 0.5231 0.513
0.1052 0.117 0.1148
210
94
No.of Pairs
Z
P
20
3.919
<0.001
2.
3.
4.
5.
Akunchan Prasaranyoh Shula BT AT Diff Pidanasahatva BT AT Diff Shulasya Kala BT AT Diff Anidra BT AT Diff.
1.8 0.5 1.3
0.5231 0.607 0.4702
0.117 0.1358 0.1052
1.9 0.55 1.35
0.5525 0.6048 0.4894
0.1236 0.1353 0.1095
1.55 0.55 1
0.6048 0.6048 0.7255
0.1353 0.1353 0.1623
1.5 0.25 1.25
0.513 0.4443 0.6387
0.1148 0.0994 0.1429
210
20
3.919
<0.001
210
20
3.919
<0.001
120
15
3.407
<0.001
171
18
3.72
<0.001
Statistical Analysis of the Effect of Therapy on Symptoms of Katishula of Group A by Wilcoxon-Matched –Pairs Signed Ranks Test: Katishula: Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31) Akunchan Prasaranyoh Shula: Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31)
94
Pidansahatva :- Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31) Shulasya Kala: Sum of all signed ranks was 120.The numbers of pairs were 15. Z value was 3.407, which was statistically very highly significant, P<0.001 (Table-31) Anidra: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.72, which was statistically very highly significant, P<0.001 (Table-31)
TABLE-32 Table Showing Effect on Symptoms of 20 Patients of Katishula of Group B by Wilcoxon- Matched –Pairs-Signed-Ranks Test
Sr. no 1
2.
Symptom Katishula BT AT Diff. Akunchan Prasaranyoh Shula BT AT Diff
SD
SEd
Sum of All Signed Ranks
2.4 1.25 1.15
05026 0.7164 0.4894
0.1124 0.1603 0.1095
190
1.85 0.8 1.05
0.8127 0.8335 0.394
0.1818 0.1865 0.0882
Mean
94
190
No.of Pairs
19
Z
3.82
19
3.82
P
<0.001
<0.001
3.
4.
5.
Pidansahatva BT AT Diff Shulasya Kala BT AT Diff Anidra BT AT Diff.
1.9 0.8 1.1
0.7182 0.9515 0.5525
0.1607 0.2129 0.1236
1.8 0.7 1.1
0.7678 0.8013 0.5525
0.1718 0.1793 0.1236
1.4 0.45 0.95
0.5026 0.6048 0.6048
0.1124 0.1353 0.1353
171
18
3.723
<0.001
171
18
3.723
<0.001
136
16
3.516
<0.001
Statistical Analysis of the Effect of Therapy on Symptoms of Katishula of Group B by Wilcoxon - Matched –Pairs Signed Ranks Test Katishula : Sum of all signed ranks was 190.The number of pairs were 19. Z value was 3.82, which was statistically very highly significant, P<0.001 (Table-32) Akunchan Prasaranyoh Shula: Sum of all signed ranks was 190.The numbers of pairs were 19. Z value was 3.82, which was statistically very highly significant, P<0.001 (Table-32) Pidansahatva: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.723, which was statistically very highly significant, P<0.001 (Table-32)
94
Shulasya Kala: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.723, which was statistically very highly significant, P<0.001 (Table-32) Anidra: Sum of all signed ranks was 136.The number of pairs were 16. Z value was 3.5162, which was statistically very highly significant, P<0.001 (Table-32)
TABLE-33 Table Showing Comparison between two groups with respect to Symptoms Score by Mann-Whitney test Sr. no
Symptom
R1
Mean
U
SD
1
Katishula
455
190
135
35.59
2.
Akunchan Prasaranyoh Shula
437
190
153
35.59
3.
Pidansahatva
413
180
157
34.20
4.
Shulasya Kala
270
135
120
19.55
5.
Anidra
344
144
115
28.98
94
Mean ± 1.96SD 120.25259.75 120.25259.75 112.96247.032 96.682173.31 87.2200.80
Z
P
1.53
>0.05
1.32
>0.05
0.65
>0.05
0.741
>0.05
0.983
>0.05
Comparison between two groups with respect to symptom score was statistically evaluated by Mann-Whitney test. There is no significant difference was found in two groups.
95
TABLE- 34
Table Showing Effect on Physical Parameters of 40 Patients of KATISHULA
Sr. No .
1
Physical Parameters
Angle of Flexion (in deg.) Group A Group B
2
Angle of Extension (in deg) Group A Group B
3
Distance Between Ground And Middle Finger of Patient (in cm) Group A Group B
Mean ± SD
Mean of Diff.
BT
AT
94.75 ± 10.696
104.25 ± 11.728
9.5 ±3.203
90.25 ± 11.751
97.5 ± 11.865
7.25 ± 3.795
19.25 ± 4.375
25 ± 4.588
6.5 ± 2.350
18.75± 4.8327
19.45 ±4.8175 21.1 ± 5.702
25 ± 3.973
15.3±5.212 17.15 ± 4.837
96
SEd
t
P
0.716
13.255
<0.001
0.849
8.537
<0.001
0.525
12.359
<0.001
0.615
10.156
<0.001
0.334
12.396
<0.001
0.5001
7.8983
<0.001
± SD
6.25 ± 2.75
4.15 ± 1.496 3.95 ± 2.235
Effect of therapy on physical parameters was statistically evaluated by Paired t test as follows. Angle of Flexion: The mean Angle of flexion in Group A before starting the treatment was 94.75 ± 10.696 which increase up to104.25±11.728.Increase in Angle of Flexion by 9.5 ±3.203 was tested statistically by paired ‘t’ test, t
was 13.255 which was very highly
significant, P<0.001(Table-34) In the same manner Angle of Flexion in Group B also increased by 7.25 ± 3.795 of which t was 8.537 and was very highly significant, P<0.001 (Table-34) Angle of Extension: Angle of Extension of Group A increased from 19.25 ± 4.375 to 25 ± 4.588. Increase in Angle of Extension by 6.5 ± 2.350 was statistically very highly significant because t was 12.359, P<0.001(table-34) In case of Group B Angle of Extension increased from 18.75 ± 4.8327 to 25 ± 3.973. Increase in Angle of Extension by 6.25 ± 2.75 was statistically very highly significant because t was 10.156, P<0.001
Distance Between Ground And Middle Finger of Patient: Distance between Ground and Middle Finger of Patient of Group A reduced from 19.45 ± 4.8175 to 15.3 ± 5.212. Decrease in Distance between Ground
97
and Middle Finger of Patient by 4.15 ± 1.496 was statistically very highly significant because t was 12.396, P<0.001(table-34) In case of Group B Distance Between Ground And Middle Finger of Patient reduced from21.1 ± 5.702 to 17.15 ± 4.837.Decrease in Distance Between Ground And Middle Finger of Patient by 3.95 ± 2.235 was statistically very highly significant because t was 7.898, P<0.001
TABLE- 35 Table Showing Effect on Haematological Parameters of 40 Patients of Katishula by Paired t Test
98
Haematolo Sr. gical No Parameters Haemoglob in 1
ESR
AT
11.685 ± 1.2209
11.895 ± 1.1264
11.755 ± 1.1865
11.99 ± 1.2809
28.5 ± 7.8639
26.75 ± 6.9953
Group A Group B Serum.Calc ium
3
BT
Mean of Diff.± SD
SEd
t
P
0.21 ± 0.5004
0.11 19
1. 875
>0. 05
0.235 ± 0.68
0.15 21
1.54 47
>0. 05
1.75 ± 4.0246
0.90 03
1.94 36
>0. 05
1.45 ± 4.3222
0.96 69
1.49 95
>0. 05
0.357 ± 0.8459
0.18 92
1.88 90
>0. 05
0.13 ± 0.3326
0.07 44
1.74 70
>0. 05
1.591 ± 5.800
1.29 7
0.039 ± 2.32
0.52 0
Group A Group B
2
Mean ± SD
Group A Group B Serum.Alka line Phosphata ge
30.25 ± 7.3044
28.8 ± 6.8333
8.685 ± 0.825
9.0425 ± 0.6904
8.23 ± 0.6449
8.36 ± 0.6159
63.69 ± 17.322
62.1 ± 13.095
5 Group A Group B
58.58 ± 3.876
58.54 ± 4.153
1.22 5 0.07
>0. 05 >0. 05
Effect of Therapy on Hematological Parameters: Hemoglobin: Hemoglobin slightly increased by 0.21 ± 0.5004 in Group A, paired t was 1.875 and was insignificant. In Group B it was increased by 0.235 ± 0.68. Paired t was 1.5447 which was also insignificant. (Table - 35)
99
ESR: ESR decreased by 1.75 ± 4.0246 in Group A, paired t was 1.94 and was insignificant. In Group B it decreased by 1.45 ± 4.322. Paired t was 1.4995 which was also insignificant. (Table - 35)
Serum Calcium: Sr.Calcium increased by 0.3575 ± 0.8459 in Group A, paired t was 1.8890 and was insignificant. In Group B it was increased by 0.13 ± 0.3326. Paired t was 1.7470 which was also insignificant. (Table-35 Serum Alkaline Phosphatage: Sr.Alkaline Phosphatage decreased by 1.591 ± 5.800 in Group A, paired t was 1.225 and was insignificant. In Group B it was decreased by 0.039 ± 2.32. Paired t was 0.07 which was also insignificant. (Table - 35)
TABLE-36
100
Table Showing Effect on Lipid profile Parameters of 40 Patients of Katishula by Paired t Test
Sr. No
Lipid Profile Paramete rs
Mean ± SD BT
Cholester 178.69 ± ol 35.8741 1
Group A Group B Triglyceri de
2
HDL Group A Group B LDL 4
137.595 ± 80.222
Group A Group B
3
180.4 3± 36.927
173.465 ± 36.29
5.225 ± 8.2879
172.5 ± 31.375
7.90 ± 12.720
2.845
2.77
10.215 ± 23.171 8
5.183 8
1.97 05
5.033 1
1.92 12
1.417 5
2.25 25
127.38 ± 73.32
136.64 ± 66. 7708
126.975 ± 72.6947
32.267 ± 5.7796
35.46 ± 6.9766
3.193 ± 6.3364
33.084 ± 6.2411
30.18 ± 4.90
2.89 ± 5.15
148.06 ± 36.58
153.03 ± 38.1890
4.969 ± 13.487
Group A Group B
AT
Mean of Diff. ± SD
147.483 ± 28.8153
144.006 5± 29.277
9.67 ± 22.49
3.4765 ± 11.887 4
101
SEd
t
1.854 2.8 1 180
P
<0.0 5 <0.0 5 >0.0 5 >0.0 5
<0.0 5
1.154 2.50
<0.0 5
3.017 2
1.64 68
>0.0 5
2.659 3
1.30 72
>0.0 5
VLDL 5
27.095 ± 15.5057
Group A Group B
25.5455 ± 15.0714
25.222 ± 16.2808 23.9355 ± 11.7790
1.8725 ± 6.0494 1.61 ± 5.2828
1.353 3
1.38 36
1.182 5
1.36 15
>0.0 5 >0.0 5
Effect of Therapy on Lipid Prpfile Parameters:Cholesterol: Cholesterol of Group A decreased from 178.69 ± 35.8741 to 173.465 ± 36.2945.Decrease in cholesterol by 5.225 ± 8.2879, was statistically significant because t was 2.8180, P<0.05 (table-36) In case of Group B cholesterol slightly decreased from 180.43 ± 36.92 to 172.5 ± 31.375.decrease in cholesterol by 7.90 ± 12.720 was statistically significant because t was 2.77, P<0.05 (table – 36)
HDL: HDL of Group A increased from 32.267 ± 5.7796 to 35.46 ± 6.9766. Increase in HDL by 3.193 ± 6.3364 was statistically significant because t was 2.2525, P<0.05 (table-36) In case of Group B HDL decreased from 33.084 ± 6.2411 to 30.18 ± 4.90. Decrease in HDL by 2.89 ± 5.15 was statistically insignificant because t was 2.50, P<0.05 (Table-36)
102
Triglyceride: Triglyceride of Group A decreased from 137.59 ± 80.222 to 127.38 ± 73.32. Decrease in Triglyceride by 10.215 ± 23.1718 was statistically insignificant because t was 1.9705, P>0.05 (table-36) In case of Group B triglyceride decreased by 136.64 ± 66.7708 was statistically insignificant because t was 1.9212, P>0.05 (table-36)
LDL: LDL increased by 4.969 ± 13.487 in Group A, paired t was 1.6468 which was insignificant. In Group B it increased by 3.4765 ± 11.8874. Paired t was 1.307 which was also insignificant. (Table - 36)
VLDL: - VLDL decreased by1.87 ± 6.0494 in Group A; paired t was 1.38 and was insignificant. In Group B it decreased by 1.61 ± 5.2858. Paired t was 1.36 and was also insignificant. (Table - 36)
TABLE- 37 Table Showing Variance Ratio Test before Treatment of Physical Parameters Sr. No
Physical Parameters
1 2
Before Treatment SD Group A SD
Group B SD
F Ratio
Angle of Flexion
10.696
11.751
1.20
>0.05
Angle of Extension
4.375
4.832
1.21
>0.05
103
P
3
Distance Between Ground And Middle Finger of Patient
4.817
5.702
1.40
>0.05
Variance Ratio Test Before Treatment:Variance ratio for Angle of Flexion, Angle of Extension, Distance between Ground and Middle Finger of Patient, presented in Table-37 showed that there was no significant difference between two groups with respect to this physical parameters. Therefore further statistical evaluation was done to see the difference between two groups with respect to these characters only by unpaired t test TABLE-38 Table Showing Variance Ratio Test before Treatment of Lipid Profile Parameters Before Treatment SD Sr. No
Lipid Profile Parameters
Group ASD
Group BSD
F Ratio
P
1
Cholesterol
35.874
36.927
1.059
>0.05
2
HDL
5.779
6.241
1.16
>0.05
104
Variance ratio for Cholesterol, HDL in table – 38 showed that there was no significant difference between two groups with respect to these lipid profile parameters. Therefore further statistical evaluation was done to see the difference between two groups with respect to these characters by unpaired t test. TABLE-39 Table Showing Comparison between Two Groups by Unpaired t Test Mean of Diff. ± SD Sr. No
Parameters
1.
Sed.
t
P
Group A
Group B
Cholesterol
5.225 ± 8.287
7.90 ± 12.720
3.39
0.78
>0.05
2.
HDL
3.193±6.336
2.89 ± 5.15
1.825
0.16
>0.05
3.
Angle of Flexion
9.5 ± 3.203
7.25 ± 3.795
1.01
2.227
<0.05
4.
Angle of Extention
6.5 ± 2.350
6.25 ± 2.75
0.80
0.937
>0.05
5.
Distance Between Ground And Middle Finger of Patient
4.15 ± 1.496
3.95 ± 2.235
0.60
0.33
>0.05
Comparison between Two Groups:
105
Comparison between two groups were statistically done by unpaired t’ test. Angle of Flexion: Mean of difference in Group A was 9.5 ± 3.203 which was compared with that of mean of difference in Group B. It was 7.25 ± 3.795.Unpaired t was 2.227, P <0.05 which suggested that difference of mean exhibited by Group A was significant. (Table-39) Angle of Extension:- Mean of difference in Group A was 6.5 ± 2.350 which was compared with that of mean of difference in Group B. It was 6.25 ± 2.75.Unpaired t was 0.937, P >0.05 which suggested that there was no significant difference of mean between two groups.(Table-39) Distance between Ground and Middle Finger of Patient: - Mean of difference in Group A was 4.15 ± 1.496 which was compared with that of mean of difference in Group B. It was 3.95 ± 2.235.Unpaired t was 0.33, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39) Cholesterol: - Mean of difference in Group A was 5.225 ± 8.287 which was compared with that of mean of difference in Group B. It was 7.90 ± 12.720.Unpaired t was 0.78, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39) HDL: - Mean of difference in Group A was 3.193 ± 6.3364 which was compared with that of mean of difference in Group B. It was 2.89 ±
106
5.15.Unpaired t was 0.1660, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39)
Total Effect of Therapy: Total effect of therapy has been evaluated in terms of cured, markedly improved, improved and unchanged.
TABLE-40 Table Showing Total Effect of Therapy in 20 Patients of Katishula of Group A. Sr. No. 1 2 3 4 5 6 7 8 9 10
Ave.% of Ave.% of Relief in Relief in Symptoms Signs 11.53069 16.85102 26.76834 8.838555
93.3333 3 60 46.6666 7
13.59218
50 93.3333 3 93.3333 3
14.34815
90
15.02229
100
8.936694 9.131983
50 50
9.02232
Total
Total % of Relief
104.86 4 76.851 02 73.435 01 58.838 55 102.35 57 106.92 55 104.34 82 115.02 23 58.936 69 59.131
52.4320 1 Markedly Improved 38.4255 1 Improved
107
36.7175 29.4192 8 51.1778 3 53.4627 6 52.1740 8 57.5111 5 29.4683 5 29.5659
Remarks
Improved Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved
11 12 13 14 15 16 17 18 19 20
16.09553
100
20.14396
30
14.38409
100
16.33155
100
22.03878
50
21.74125
22.05475
90 76.6666 7 93.3333 3
16.36823
40
25.02518
40
26.06156
98 116.09 55 50.143 96 114.38 41 116.33 16 72.038 78 111.74 13 102.72 82 115.38 81 56.368 23 65.025 18
9 58.0477 7 25.0719 8 57.1920 4 58.1657 8 36.0193 9 55.8706 3 51.3641 1 57.6940 4 28.1841 2 32.5125 9
Markedly Improved Improved Markedly Improved Markedly Improved Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved
TABLE-41 Table Showing Total Effect of Therapy in 20 Patients of Katishula of Group B. Sr.No. 1 2 3 4 5 6
Ave.% of Relief in Symptoms
Ave.% of Relief in Signs
14.83455
90
10.23479
90
15.89428
90
11.70406
40
32.4335
20
23.55416
36.66667
Total
Total % of Relief
Remarks
104.834 5 100.234 8 105.894 3 51.7040 6
52.4172 7 Markedly Improved
52.4335 60.2208 3
Improved
108
50.1174 52.9471 4 25.8520 3 26.2167 5 30.1104 1
Markedly Improved Markedly Improved Improved
Improved
7 8 9 10 11 12 13 14 15 16 17 18 19 20
15.66856
40
9.286239
100
10.42266
100
12.97731
90
13.38216
90
13.38523
90
6.884963
50
33.4733
16.66667
13.01946
50
11.49058
40
6.772823
93.33333
17.24505
86.66667
19.5741
36.66667
13.43026
36.66667
55.6685 6 109.286 2 110.422 7 102.977 3 103.382 2 103.385 2 56.8849 6 50.1399 7 63.0194 6 51.4905 8 100.106 2 103.911 7 56.2407 7 50.0969 3
27.8342 8 54.6431 2 55.2113 3 51.4886 5 51.6910 8 51.6926 1 28.4424 8 25.0699 8 31.5097 3 25.7452 9 50.0530 8 51.9558 6 28.1203 8 25.0484 6
Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved Improved Improved Markedly Improved Markedly Improved Improved Improved
TABLE-42 Table Showing Total Effect of Therapy in 40 Patients of Katishula Sr.No.
Total
Group A
109
Group B
Total
Effect of Therpy
No. of Pts.
%
No.of Pts.
%
No. of Pts.
%
1
Cured
0
0%
0
0%
0
0%
2
Markedly Improved
11
55%
10
50%
21
52.5%
3
Improved
09
45%
10
50%
09
47.5%
4
Unchanged
0
0%
0
0%
0
0%
In case of Group A 11 patients (55%) were markedly improved and 09 patients (45%) were improved. In case of Group B 10 patients (50%) were markedly improved and 10 patients (15%) were improved.
TABLE-43 Table Showing Comparison between Two Groups by Chi-Square Test Sr. No.
Group
Improved
110
Markedly improved
Total
Chi-square value
1
Group A
(O)=09
(O)=11
(E)=9.5
(E)=10.5
20
0.08 2
Group B
(O)=10
(O)=10
(E)=9.5
(E)=10.5
20
>0.05
Comparison between two groups was statistically evaluated by chi-square test. The value is 0.08 which was statistically insignificant which suggested that there was no significant difference between two groups with respect to therapy.
111
112
The study entitled “Effect of panchatikta Taila Matra Basti in the patients suffering from Katishula vis-a vis Lumbar Spondylosis.” was planned to evaluate effect of Panchatikta Taila on the patient of Katishula. For that Panchatikta Taila Matra Basti along with Madhu was given to one group comprising 20 patients of Katishula for 9 days. This group of treatment was termed as Group A. To compare the effect of Madhu in Matra Basti, another group comprising 20 patients of Katishula was given Panchatikta Taila Matra Basti for 9 days. This group was termed as Group B. Prior to start of the study in both groups, patients selected for study were closely observed for a period of two days. In this period of observation detailed history of patients was evaluated as per Performa of case record form mentioned in the ending of materials and methods. In these two days, all investigations were carried out and these values were termed as before treatment. As well as the status of the patient was also recorded with respect to symptoms and signs found in the patient of Katishula of this series. After completion of duration all the required investigations of all the patients from both groups were again done. All these values were recorded and termed as after treatment values. The status of all the symptoms and signs were also recorded after completion of treatment.
94
Thus the change in the status of symptoms, signs and investigations were recorded. The history recorded in this study on case record form, revealed the facts and findings, which are presented herewith in the tabular form. Some of them are highlighted with the help of graphical presentations. TABLE-9 Table Showing Age-wise distribution of 40 patients of KATISHULA Sr. Age Group No.
Group A
Group B
No. of pts.
%
No. of pts
%
1)
00
00
00
00
00
09
45
10
50
19
47.5
Praudhavasta 11
55
10
50
21
52.5
Balyavasta
Total No. Percentage Patients
(0-16yrs.) 2)
Tarunavasta (17-40yrs.)
3)
(41-60 yrs.)
.
Ayurvedic concept of age is somewhat different with respect to
modern science.Age group as described by Sharangdhara was considered in this study. In the present study maximum number of patients (52.5%) were from the praudha-Avastha of Age while, 47.5% patients were from taruna avasta (Table 9).
94
TABLE-10 Table Showing Sex-wise distribution of 40 patients of KATISHULA Sr. Sex No.
Group A
Group B
Total No. Percentage Patients
No. of pts.
%
No. of pts
%
1)
Male
6
30
8
40
14
35
2)
Female
14
70
12
60
26
65
Table-10 reveals that maximum numbers of patients (65%) were female whereas 35% of patients were male. TABLE-11 Table Showing Religion -wise distribution of 40 patients of KATISHULA Sr. Religion No.
Group A
Group B
No. of pts.
%
No. of pts
%
1)
Hindu
19
95
18
90
37
92.5
2)
Muslim
01
05
00
00
1
2.5
3)
Christian
00
00
02
10
2
5.0
94
Total No. Percentage Patients
Table-11 data reveals that maximum number of patients (92.5%) were from Hindu religion, followed by 5% from Christian religion whereas 2.5% from Muslim religion.
TABLE-12 Table Showing Economical status of 40 patients of KATISHULA Sr. Economical No. status
Group A
Group B
Total No. Percentage Patients
No. of pts.
%
No. of pts
%
1)
Poor
02
10
01
05
03
7.5
2)
Middle class
18
90
18
90
36
90
3)
Rich
00
00
01
05
01
2.5
90% of patients in Group A and 90% of Group B were found to be Middle-class income group. However 10% from Group Aand 5% from Group B were found to be Lower class group. While only 5% of higher class noted from Group B. (Table 12) TABLE-13 Table Showing Educational status of 40 patients of KATISHULA Sr. Educational No. status
Group A No.
Group B
%
No.
94
%
Total No. Patients
Percentage
of pts.
of pts
1)
Uneducated
01
05
03
15
04
10
2)
Educated up to SSC
09
45
07
35
16
40
3)
HSC
04
20
03
15
7
17.5
4)
Graduate
06
30
07
35
13
32.5
In this series 05% people from Group A and15% from Group B were found to be uneducated. Remaining patients were educated up to different level of education. In that 45% in Group A and 35% in Group B were found to be educated up to HSC. While 30% in Group A and 35% in Group B, were found to be graduate people. TABLE-14 Table Showing Chronicity of disease of 40 patients of KATISHULA Group A Sr. No.
Chronicity of disease
No. of pts.
1)
0-1 yrs
2)
Group B %
Total No. Patients
Percentage
08
40
17
42.5
30
07
35
13
32.5
04
20
04
20
08
20
01
5
01
5
02
5
%
No. of pts
09
45
1-5 yrs
06
3)
5-10 yrs
4)
<10 yrs
In this maximum patient (42.5%) have symptoms since last 1year back.32.5%have same symptom since 5 years.20% patients
94
have same complaint since 10 years and rest 5% since more than 10 years.
TABLE-15 Table Showing Marital status of 40 patients of KATISHULA
Sr. No.
Group A Family History
Group B
No. of pts.
%
No. of pts
%
Total No. Patients
Percentage
1)
Unmarried
01
05
00
00
01
2.5
2)
Married
18
90
19
95
37
92.5
3)
Widow
01
05
01
05
02
05
4)
Widower
00
00
00
00
00
00
In above table only 5% were unmarried, maximum i.e.90% in Group A and 95% in Group B were married. Only 5% were widow in each group TABLE-16 Table Showing Dominant Rasa in Ahar of 40 patients of KATISHULA
95
Sr. No.
Dominant Rasa in Ahar
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Madhur
12
60
10
50
22
55
2)
Amla
12
60
15
75
27
67.5
3)
Lavan
05
25
08
40
13
32.5
4)
Katu
19
95
18
90
37
92.5
5)
Tikta
08
40
08
40
16
40
6)
Kashaya
03
15
01
05
04
10
Ayurveda bestowed the importance of diet having all six types of Rasa.Most of the Ayurvedic physicians of ancient era opined that the diet having six types of Rasa should be ingested. People may have the habit of consuming one or two particular Rasas excessively and then may produce diseases related to it. It was revealed that 95%of peoples in Group As and 90% Group B were having the habit of ingesting food having Katu rasa. Some of them had having habit of taking excess Madhura and Amla Rasa, they were 60% in Group A and 50% and 75% in Group B. Incidance of Tikta,Kashay and Lavana rasa also noted as shown in the table 16. TABLE-17 Table Showing Type of Food Ingested by of 40 patients of KATISHULA Sr.
Type of
Group A
Group B
94
Total
No. Percentage
No.
Patients Food Ingested
No. of pts.
%
No. of pts
%
1)
Vegetarian
06
30
08
40
14
35
3)
Mixed
14
70
12
60
26
65
The above table shows that more patients were having mixed diet (70% in Group A and 60% in group B).Rest of having Vegetarian diet (30% in Group A and 40% in group B). TABLE-18 Table showing dominant Guna in ahara by 40 patients of KATISHULA Sr. No.
Dominant Guna in Ahar
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Ushna
06
30
07
35
13
32.5
2)
Shita
14
70
13
65
27
67.5
3)
Laghu
14
70
12
60
26
65
4)
Guru
06
30
08
40
14
35
5)
Snigdha
08
40
09
45
17
42.5
6)
Ruksha
12
60
11
55
23
57.5
7)
Veg.oil
20
100
20
100
40
100
8)
Ghee
03
15
05
25
08
20
94
In this study, maximum patients were taking shita and Laghu guna pradhan ahara. All patients were used veg.oil in their ahara. TABLE-19 Table Showing Vyasana of 40 patients of KATISHULA Sr. No.
Vyasana
Group A
Group B
No. of pts.
%
No. of pts
%
Total No. Percentage Patients
1)
Madyapana
01
05
02
10
03
7.5
2)
Tobacco
05
25
07
35
12
30
3)
Tea/Coffee
19
95
20
100
39
97.5
4)
Smoking
01
05
03
15
04
10
5)
None
01
05
00
00
01
2.5
In this study, maximum patients were addicted to bad habit. It shows maximum patient was addicted to Tea or Coffee. Tobacco chewing was next to it with 25% in Group A and 35% in Group B. Smoking and Madyapana were 05% in Group A and 15%, 10% in Group B respectively. TABLE-20 Table Showing Type of Work done by 40 patients of KATISHULA Sr.
Type of
Group A
Group B
94
Total No.
Percentage
No.
Work
No. of pts.
%
No. of pts
%
1)
Sedentary
06
30
08
40
14
35
2)
Standing
03
15
03
15
06
15
3)
Sitting
04
20
02
10
06
15
4)
Labor
07
35
07
35
14
35
Patients
The type of work done by the patient is also as important as Aahar concept narrated by the Acharya Charak. Therefore the history of work done by patients was pinpointed. It is observed that the standing type of work done by patients of Katishula in the both groups was 15% and the sitting type of work done by the patient’s was 20% in Group A and 10% in Group B as shown in the table 20. The maximum patients 35% in the both groups was found to be laborious worker. In the above study 30% in Group A and 40% in Group B of patients having sedentary type of work TABLE-21 Table showing Sara Parikshana by 40 patients of KATISHULA Sr. No.
Group A Sara Parikshana
No. of pts.
%
Group B No. of pts
94
%
Total No. Percentage Patients
1)
Avara
06
30
05
25
11
27.5
2)
Madhyam
11
55
12
60
23
57.5
3)
Pravara
03
15
03
15
06
15
In this study, maximum patients were Madhyam Sara (57.5%). Only 15% patient’s were Pravara Sara as shown in table. TABLE-22 Table Showing Doshaj Prakriti in 40 patients of KATISHULA Group A Sr. No.
Doshaj Prakriti
No. of pts.
1)
Vata-Pittaja
2) 3)
Group B %
Total No. Patients
Percentage
10
50
19
42.5
15
04
20
07
17.5
40
06
30
14
35
%
No. of pts
09
45
Pitta-Kaphaja
03
Kapha-Vataja
08
Prakruti parikshan is the basic concept of Ayurved and it has much more importance in Chikitsa.In above table 45% of Group A and 50% of Group B constituted Vata-Pittaja type Prakriti.The incidence for Pitta-Kaphaja was 15% and 20% patients of Group A and Group B respectively. 40% and 30% patients of Group A and Group B respectively in Kapha-Vataja type of Prakriti. TABLE-23
94
Table Showing Samhanana of 40 patients of KATISHULA Group A Sr. Samhanana No.
No. of pts.
Group B
%
No. of pts
%
Total No. Patients
Percentage
1)
Avar
05
25
06
30
11
27.5
2)
Madhyam
11
55
11
55
22
55
3)
Pravara
04
20
03
15
07
17.5
TABLE-24 Table Showing Satva-Bala of 40 patients of KATISHULA Group A Sr. No.
Satva-Bala
No. of pts.
1)
Avar
2) 3)
Group B %
Total No. Patients
Percentage
05
25
11
27.5
55
12
60
23
57.5
15
03
15
06
15
%
No. of pts
06
30
Madhyam
11
Pravara
03
TABLE-25 Table Showing Vyayama Shakti Parikshana of 40 patients of KATISHULA
94
Group A Sr. No.
Vyayama Shakti
No. of pts.
1)
Avar
2) 3)
Group B %
Total No. Patients
Percentage
03
15
07
17.5
55
11
55
22
55
25
06
30
11
27.5
%
No. of pts
04
20
Madhyam
11
Pravara
05
TABLE-26 Table Showing Akrititaha Parikshana of 40 patients of KATISHULA Group A Sr. No.
Akriti
No. of pts.
1)
Krisha
2) 3)
Group B %
Total No. Patients
Percentage
08
40
15
37.5
50
09
45
19
47.5
15
03
15
06
15
%
No. of pts
07
35
Madhyam
10
Sthula
03
TABLE-27 Table Showing Deshatah Parikshana of 40 patients of KATISHULA Group A Sr. No.
Deshatah
No. of pts.
1)
Anupa
2) 3)
Group B %
Total No. Patients
Percentage
08
40
18
45.5
30
07
35
13
32.5
20
05
25
09
%
No. of pts
10
50
Jangla
06
Sadharana
04
94
22.5
TABLE-28 Table Showing Ahar-Shakti Parikshana of 40 patients of KATISHULA Group A Sr. No. A)
Ahar-Shakti
No. of pts.
Group B
%
No. of pts
%
Total No. Patients
Percentage
Abhyavaharana Shakti
1)
Avar
04
20
03
15
07
17.5
2)
Madhyam
14
70
12
60
26
65
3)
Pravara
02
10
05
25
07
17.5
B)
Jaran-Shakti
1)
Avar
05
25
05
25
10
25
2)
Madhyam
13
65
10
50
23
57.5
3)
Pravara
02
10
05
25
07
17.5
C)
Agni
1)
Visham
08
40
06
30
14
35
2)
Tikshna
03
15
02
10
05
12.5
3)
Manda
02
10
03
15
05
12.5
4)
Madhyam
07
35
09
45
16
40
Dashavidha – Parikshana : All the patients included in this study were examined with respect
to
Ashtavidha,
Dashavidha,
94
Strotasa
etc.
Parikshana.
Dashvidha parikshana such as Prakruti, Sara, etc. help to have the idea regarding of the dominance of Bala, of the patients. In this series Dvandva type of Prakruti was encounted which is mention before. Most of the patients are having Madhyam type of Samhanan (55% of Group A and Group B as per Table- 23). In this study Satva was also investigated. Maximum number patients (about 55 % of Group A and 60%of Group B) having Madhyam type of Satva already shown in Table – 24) Vyamshakti is nothing but the work. A parameter which gives idea about Deha Bala. In the Katishula, Bala of patients which depends on Dhatu-Saratva is reduced. Maximum patients of this series had Madhyam Vyam Shakti(55% in both group), which had been indicated in table-25. Examination of Agni: Examination of status of Agni is one of the important factors, as Proper Agni is essential for the metabolism. Therefore it is at most important to have the idea regarding the status of Agni of patients of Katishula. The patients registered; in this series were investigated with respect to Abyavaran Shakti, Jaran Shakti. It was noted that 70% patients in Group A and 60% in Group B had Madhyam Abhyavaran
95
Shakti, while that of 65% of Group A and 50% of Group B having Madhyam type of Jaran shakti. Also it can be noted that 20% of Group A and 25% of Group B patients having Pravara Abhyavaran shakti and only 10% and 25% respectively having Pravara Jaran shakti. It means that peoples of Katishula were more likely goes towards Mithya-ahar. Examination of Sthulata Krishata exclusively principles of management of Katishula, depends upon Sthulata and Krishata of Patients. In this series 50% patients of treated, and 45% patients of controlled having Madhayam Akruti; Krisha was noted in 35% and 40% patients of Group A and Group B respectively. (Table – 26) About 50% of Group A and 40% of controlled patients was found to be residential of Anupa Desh, 30% and 35% patients of Group A and Group B was found to be residential of Jangala Desh as per shown in Table – 27.
96
TABLE-29 Showing Incidence of main Vyadhi Ghataka involved 40 patients of KATISHULA Sr. No.
Vyadhi Ghatak involved
Group A
Group B
No. of pts.
No. of pts
%
%
Total No. Patients
Percentag e
A) Dosha-Involved 1)
VataDominance
20
100
20
100
40
100
2)
PittaDominance
12
60
09
45
21
52.5
3)
KaphaDominance
04
20
05
25
09
22.5
B) Dhatu-Involved 1)
Rasa Dhatu
06
30
05
15
11
27.5
2)
Rakta Dhatu
11
55
13
65
24
60
3)
Mamsa Dhatu
05
25
03
15
08
20
4)
Meda Dhatu
03
15
04
20
07
17.5
5)
Asthi Dhatu
20
100
20
100
40
100
6)
Majja Dhatu
12
60
11
55
23
57.5
7)
Shukra
00
00
00
00
00
00
98
Dhatu C) Strotas Involved 1)
Rasa-vaha
12
60
10
50
22
55
2)
Rakta-vaha
09
45
09
45
18
45
3)
Mamsa-vaha
05
25
05
25
10
25
4)
Meda-vaha
03
15
03
15
06
15
5)
Asthi-vaha
20
100
20
100
40
100
6)
Majja-vaha
20
100
18
90
38
95
Concept of Vyadhi in Ayurveda is unique, which deals with Dosha, Dushya, Srotas and particular region on the body. Katishula is generalized disease in which whole body is affected.
Incidence for Dosha dushti: Incidence for involvement of Dosha was evaluated with the help of Dosha-Vruddhi Laxanas. In this study 100% of patients in the both groups exhibited dominance of Vata Dushti Laxanas. Dominance of Pitta dushti was found in 60% in Group A and 45% in group B of Katishula, while that Kapha dominance was found to be 20% and 25% in Group A and Group B respectively. (Table 21) Incidence for Dhatu Dushti:
99
In this study it was observed that Asthi Dhatu Dushti was observed in all patients of both the groups. Mamsa Dushti was found in 25% of Group A and 15% of Group B of patients. 55% of Group A and 65% of Group B of patients is found to be Dushti in Rakta Dhatu also. 60% of Group A and 55% of Group B of patients is found to be Majja Dhatu Dushti. Involvement of Srotasa: In this study Asthivaha Srotas were involved in all patients of both the groups.100% and 90% of patients in Group A and Group B was found to be Dushti in Majjavaha Srotas respectively. 45% in Raktavaha Strotas,25% in Mansavaha Strotas and 15% in Medavaha Strotas Dushti were found in both group respectively.
TABLE-30 Table Showing Effect of Symptoms Score of 40 Patients of Katishula
Group A Sr. No. 1
Symptom BT Katishula
46
AT 16
Group B
Differe nce
Percent age of Relief
BT
AT
Differ ence
Percent age of Relief
30
65.21
48
25
23
47.91
94
2 3
Akunchan Prasaranyoh Shula Pidanasahat va
36
10
26
72.22
37
16
21
56.75
38
11
27
71.05
38
16
22
57.89
4
Shulasya Kala
31
11
20
64.51
36
14
22
61.11
5
Anidra
30
5
25
83.33
28
9
19
67.85
Effect of Therapy on symptoms Score: It was observed that overall percentage of relief was more in Group A than Group B. The symptoms such as katishala, Akunchan Prasaranyoh Shula, pidansahatva, shulasya kala, anidra etc. were studied in this series as described in Table
TABLE-31 Table Showing Effect on Symptoms of 20 Patients of Katishula of Group A group by Wilcoxon-Matched –Pairs-Signed-Ranks Test
Sr. no 1
Symptom
Mean
SD
SEd
Sum of All Signed Ranks
Katishula BT AT Diff.
2.3 0.8 1.5
0.4702 0.5231 0.513
0.1052 0.117 0.1148
210
94
No.of Pairs
Z
P
20
3.919
<0.001
2.
3.
4.
5.
Akunchan Prasaranyoh Shula BT AT Diff Pidanasahatva BT AT Diff Shulasya Kala BT AT Diff Anidra BT AT Diff.
1.8 0.5 1.3
0.5231 0.607 0.4702
0.117 0.1358 0.1052
1.9 0.55 1.35
0.5525 0.6048 0.4894
0.1236 0.1353 0.1095
1.55 0.55 1
0.6048 0.6048 0.7255
0.1353 0.1353 0.1623
1.5 0.25 1.25
0.513 0.4443 0.6387
0.1148 0.0994 0.1429
210
20
3.919
<0.001
210
20
3.919
<0.001
120
15
3.407
<0.001
171
18
3.72
<0.001
Statistical Analysis of the Effect of Therapy on Symptoms of Katishula of Group A by Wilcoxon-Matched –Pairs Signed Ranks Test: Katishula: Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31) Akunchan Prasaranyoh Shula: Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31)
94
Pidansahatva :- Sum of all signed ranks was 210.The number of pairs were 20. Z value was 3.9199, which was statistically very highly significant, P<0.001 (Table-31) Shulasya Kala: Sum of all signed ranks was 120.The numbers of pairs were 15. Z value was 3.407, which was statistically very highly significant, P<0.001 (Table-31) Anidra: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.72, which was statistically very highly significant, P<0.001 (Table-31)
TABLE-32 Table Showing Effect on Symptoms of 20 Patients of Katishula of Group B by Wilcoxon- Matched –Pairs-Signed-Ranks Test
Sr. no 1
2.
Symptom Katishula BT AT Diff. Akunchan Prasaranyoh Shula BT AT Diff
SD
SEd
Sum of All Signed Ranks
2.4 1.25 1.15
05026 0.7164 0.4894
0.1124 0.1603 0.1095
190
1.85 0.8 1.05
0.8127 0.8335 0.394
0.1818 0.1865 0.0882
Mean
94
190
No.of Pairs
19
Z
3.82
19
3.82
P
<0.001
<0.001
3.
4.
5.
Pidansahatva BT AT Diff Shulasya Kala BT AT Diff Anidra BT AT Diff.
1.9 0.8 1.1
0.7182 0.9515 0.5525
0.1607 0.2129 0.1236
1.8 0.7 1.1
0.7678 0.8013 0.5525
0.1718 0.1793 0.1236
1.4 0.45 0.95
0.5026 0.6048 0.6048
0.1124 0.1353 0.1353
171
18
3.723
<0.001
171
18
3.723
<0.001
136
16
3.516
<0.001
Statistical Analysis of the Effect of Therapy on Symptoms of Katishula of Group B by Wilcoxon - Matched –Pairs Signed Ranks Test Katishula : Sum of all signed ranks was 190.The number of pairs were 19. Z value was 3.82, which was statistically very highly significant, P<0.001 (Table-32) Akunchan Prasaranyoh Shula: Sum of all signed ranks was 190.The numbers of pairs were 19. Z value was 3.82, which was statistically very highly significant, P<0.001 (Table-32) Pidansahatva: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.723, which was statistically very highly significant, P<0.001 (Table-32)
94
Shulasya Kala: Sum of all signed ranks was 171.The numbers of pairs were 18. Z value was 3.723, which was statistically very highly significant, P<0.001 (Table-32) Anidra: Sum of all signed ranks was 136.The number of pairs were 16. Z value was 3.5162, which was statistically very highly significant, P<0.001 (Table-32)
TABLE-33 Table Showing Comparison between two groups with respect to Symptoms Score by Mann-Whitney test Sr. no
Symptom
R1
Mean
U
SD
1
Katishula
455
190
135
35.59
2.
Akunchan Prasaranyoh Shula
437
190
153
35.59
3.
Pidansahatva
413
180
157
34.20
4.
Shulasya Kala
270
135
120
19.55
5.
Anidra
344
144
115
28.98
94
Mean ± 1.96SD 120.25259.75 120.25259.75 112.96247.032 96.682173.31 87.2200.80
Z
P
1.53
>0.05
1.32
>0.05
0.65
>0.05
0.741
>0.05
0.983
>0.05
Comparison between two groups with respect to symptom score was statistically evaluated by Mann-Whitney test. There is no significant difference was found in two groups.
95
TABLE- 34
Table Showing Effect on Physical Parameters of 40 Patients of KATISHULA
Sr. No .
1
Physical Parameters
Angle of Flexion (in deg.) Group A Group B
2
Angle of Extension (in deg) Group A Group B
3
Distance Between Ground And Middle Finger of Patient (in cm) Group A Group B
Mean ± SD
Mean of Diff.
BT
AT
94.75 ± 10.696
104.25 ± 11.728
9.5 ±3.203
90.25 ± 11.751
97.5 ± 11.865
7.25 ± 3.795
19.25 ± 4.375
25 ± 4.588
6.5 ± 2.350
18.75± 4.8327
19.45 ±4.8175 21.1 ± 5.702
25 ± 3.973
15.3±5.212 17.15 ± 4.837
96
SEd
t
P
0.716
13.255
<0.001
0.849
8.537
<0.001
0.525
12.359
<0.001
0.615
10.156
<0.001
0.334
12.396
<0.001
0.5001
7.8983
<0.001
± SD
6.25 ± 2.75
4.15 ± 1.496 3.95 ± 2.235
Effect of therapy on physical parameters was statistically evaluated by Paired t test as follows. Angle of Flexion: The mean Angle of flexion in Group A before starting the treatment was 94.75 ± 10.696 which increase up to104.25±11.728.Increase in Angle of Flexion by 9.5 ±3.203 was tested statistically by paired ‘t’ test, t
was 13.255 which was very highly
significant, P<0.001(Table-34) In the same manner Angle of Flexion in Group B also increased by 7.25 ± 3.795 of which t was 8.537 and was very highly significant, P<0.001 (Table-34) Angle of Extension: Angle of Extension of Group A increased from 19.25 ± 4.375 to 25 ± 4.588. Increase in Angle of Extension by 6.5 ± 2.350 was statistically very highly significant because t was 12.359, P<0.001(table-34) In case of Group B Angle of Extension increased from 18.75 ± 4.8327 to 25 ± 3.973. Increase in Angle of Extension by 6.25 ± 2.75 was statistically very highly significant because t was 10.156, P<0.001
Distance Between Ground And Middle Finger of Patient: Distance between Ground and Middle Finger of Patient of Group A reduced from 19.45 ± 4.8175 to 15.3 ± 5.212. Decrease in Distance between Ground
97
and Middle Finger of Patient by 4.15 ± 1.496 was statistically very highly significant because t was 12.396, P<0.001(table-34) In case of Group B Distance Between Ground And Middle Finger of Patient reduced from21.1 ± 5.702 to 17.15 ± 4.837.Decrease in Distance Between Ground And Middle Finger of Patient by 3.95 ± 2.235 was statistically very highly significant because t was 7.898, P<0.001
TABLE- 35 Table Showing Effect on Haematological Parameters of 40 Patients of Katishula by Paired t Test
98
Haematolo Sr. gical No Parameters Haemoglob in 1
ESR
AT
11.685 ± 1.2209
11.895 ± 1.1264
11.755 ± 1.1865
11.99 ± 1.2809
28.5 ± 7.8639
26.75 ± 6.9953
Group A Group B Serum.Calc ium
3
BT
Mean of Diff.± SD
SEd
t
P
0.21 ± 0.5004
0.11 19
1. 875
>0. 05
0.235 ± 0.68
0.15 21
1.54 47
>0. 05
1.75 ± 4.0246
0.90 03
1.94 36
>0. 05
1.45 ± 4.3222
0.96 69
1.49 95
>0. 05
0.357 ± 0.8459
0.18 92
1.88 90
>0. 05
0.13 ± 0.3326
0.07 44
1.74 70
>0. 05
1.591 ± 5.800
1.29 7
0.039 ± 2.32
0.52 0
Group A Group B
2
Mean ± SD
Group A Group B Serum.Alka line Phosphata ge
30.25 ± 7.3044
28.8 ± 6.8333
8.685 ± 0.825
9.0425 ± 0.6904
8.23 ± 0.6449
8.36 ± 0.6159
63.69 ± 17.322
62.1 ± 13.095
5 Group A Group B
58.58 ± 3.876
58.54 ± 4.153
1.22 5 0.07
>0. 05 >0. 05
Effect of Therapy on Hematological Parameters: Hemoglobin: Hemoglobin slightly increased by 0.21 ± 0.5004 in Group A, paired t was 1.875 and was insignificant. In Group B it was increased by 0.235 ± 0.68. Paired t was 1.5447 which was also insignificant. (Table - 35)
99
ESR: ESR decreased by 1.75 ± 4.0246 in Group A, paired t was 1.94 and was insignificant. In Group B it decreased by 1.45 ± 4.322. Paired t was 1.4995 which was also insignificant. (Table - 35)
Serum Calcium: Sr.Calcium increased by 0.3575 ± 0.8459 in Group A, paired t was 1.8890 and was insignificant. In Group B it was increased by 0.13 ± 0.3326. Paired t was 1.7470 which was also insignificant. (Table-35 Serum Alkaline Phosphatage: Sr.Alkaline Phosphatage decreased by 1.591 ± 5.800 in Group A, paired t was 1.225 and was insignificant. In Group B it was decreased by 0.039 ± 2.32. Paired t was 0.07 which was also insignificant. (Table - 35)
TABLE-36
100
Table Showing Effect on Lipid profile Parameters of 40 Patients of Katishula by Paired t Test
Sr. No
Lipid Profile Paramete rs
Mean ± SD BT
Cholester 178.69 ± ol 35.8741 1
Group A Group B Triglyceri de
2
HDL Group A Group B LDL 4
137.595 ± 80.222
Group A Group B
3
180.4 3± 36.927
173.465 ± 36.29
5.225 ± 8.2879
172.5 ± 31.375
7.90 ± 12.720
2.845
2.77
10.215 ± 23.171 8
5.183 8
1.97 05
5.033 1
1.92 12
1.417 5
2.25 25
127.38 ± 73.32
136.64 ± 66. 7708
126.975 ± 72.6947
32.267 ± 5.7796
35.46 ± 6.9766
3.193 ± 6.3364
33.084 ± 6.2411
30.18 ± 4.90
2.89 ± 5.15
148.06 ± 36.58
153.03 ± 38.1890
4.969 ± 13.487
Group A Group B
AT
Mean of Diff. ± SD
147.483 ± 28.8153
144.006 5± 29.277
9.67 ± 22.49
3.4765 ± 11.887 4
101
SEd
t
1.854 2.8 1 180
P
<0.0 5 <0.0 5 >0.0 5 >0.0 5
<0.0 5
1.154 2.50
<0.0 5
3.017 2
1.64 68
>0.0 5
2.659 3
1.30 72
>0.0 5
VLDL 5
27.095 ± 15.5057
Group A Group B
25.5455 ± 15.0714
25.222 ± 16.2808 23.9355 ± 11.7790
1.8725 ± 6.0494 1.61 ± 5.2828
1.353 3
1.38 36
1.182 5
1.36 15
>0.0 5 >0.0 5
Effect of Therapy on Lipid Prpfile Parameters:Cholesterol: Cholesterol of Group A decreased from 178.69 ± 35.8741 to 173.465 ± 36.2945.Decrease in cholesterol by 5.225 ± 8.2879, was statistically significant because t was 2.8180, P<0.05 (table-36) In case of Group B cholesterol slightly decreased from 180.43 ± 36.92 to 172.5 ± 31.375.decrease in cholesterol by 7.90 ± 12.720 was statistically significant because t was 2.77, P<0.05 (table – 36)
HDL: HDL of Group A increased from 32.267 ± 5.7796 to 35.46 ± 6.9766. Increase in HDL by 3.193 ± 6.3364 was statistically significant because t was 2.2525, P<0.05 (table-36) In case of Group B HDL decreased from 33.084 ± 6.2411 to 30.18 ± 4.90. Decrease in HDL by 2.89 ± 5.15 was statistically insignificant because t was 2.50, P<0.05 (Table-36)
102
Triglyceride: Triglyceride of Group A decreased from 137.59 ± 80.222 to 127.38 ± 73.32. Decrease in Triglyceride by 10.215 ± 23.1718 was statistically insignificant because t was 1.9705, P>0.05 (table-36) In case of Group B triglyceride decreased by 136.64 ± 66.7708 was statistically insignificant because t was 1.9212, P>0.05 (table-36)
LDL: LDL increased by 4.969 ± 13.487 in Group A, paired t was 1.6468 which was insignificant. In Group B it increased by 3.4765 ± 11.8874. Paired t was 1.307 which was also insignificant. (Table - 36)
VLDL: - VLDL decreased by1.87 ± 6.0494 in Group A; paired t was 1.38 and was insignificant. In Group B it decreased by 1.61 ± 5.2858. Paired t was 1.36 and was also insignificant. (Table - 36)
TABLE- 37 Table Showing Variance Ratio Test before Treatment of Physical Parameters Sr. No
Physical Parameters
1 2
Before Treatment SD Group A SD
Group B SD
F Ratio
Angle of Flexion
10.696
11.751
1.20
>0.05
Angle of Extension
4.375
4.832
1.21
>0.05
103
P
3
Distance Between Ground And Middle Finger of Patient
4.817
5.702
1.40
>0.05
Variance Ratio Test Before Treatment:Variance ratio for Angle of Flexion, Angle of Extension, Distance between Ground and Middle Finger of Patient, presented in Table-37 showed that there was no significant difference between two groups with respect to this physical parameters. Therefore further statistical evaluation was done to see the difference between two groups with respect to these characters only by unpaired t test TABLE-38 Table Showing Variance Ratio Test before Treatment of Lipid Profile Parameters Before Treatment SD Sr. No
Lipid Profile Parameters
Group ASD
Group BSD
F Ratio
P
1
Cholesterol
35.874
36.927
1.059
>0.05
2
HDL
5.779
6.241
1.16
>0.05
104
Variance ratio for Cholesterol, HDL in table – 38 showed that there was no significant difference between two groups with respect to these lipid profile parameters. Therefore further statistical evaluation was done to see the difference between two groups with respect to these characters by unpaired t test. TABLE-39 Table Showing Comparison between Two Groups by Unpaired t Test Mean of Diff. ± SD Sr. No
Parameters
1.
Sed.
t
P
Group A
Group B
Cholesterol
5.225 ± 8.287
7.90 ± 12.720
3.39
0.78
>0.05
2.
HDL
3.193±6.336
2.89 ± 5.15
1.825
0.16
>0.05
3.
Angle of Flexion
9.5 ± 3.203
7.25 ± 3.795
1.01
2.227
<0.05
4.
Angle of Extention
6.5 ± 2.350
6.25 ± 2.75
0.80
0.937
>0.05
5.
Distance Between Ground And Middle Finger of Patient
4.15 ± 1.496
3.95 ± 2.235
0.60
0.33
>0.05
Comparison between Two Groups:
105
Comparison between two groups were statistically done by unpaired t’ test. Angle of Flexion: Mean of difference in Group A was 9.5 ± 3.203 which was compared with that of mean of difference in Group B. It was 7.25 ± 3.795.Unpaired t was 2.227, P <0.05 which suggested that difference of mean exhibited by Group A was significant. (Table-39) Angle of Extension:- Mean of difference in Group A was 6.5 ± 2.350 which was compared with that of mean of difference in Group B. It was 6.25 ± 2.75.Unpaired t was 0.937, P >0.05 which suggested that there was no significant difference of mean between two groups.(Table-39) Distance between Ground and Middle Finger of Patient: - Mean of difference in Group A was 4.15 ± 1.496 which was compared with that of mean of difference in Group B. It was 3.95 ± 2.235.Unpaired t was 0.33, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39) Cholesterol: - Mean of difference in Group A was 5.225 ± 8.287 which was compared with that of mean of difference in Group B. It was 7.90 ± 12.720.Unpaired t was 0.78, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39) HDL: - Mean of difference in Group A was 3.193 ± 6.3364 which was compared with that of mean of difference in Group B. It was 2.89 ±
106
5.15.Unpaired t was 0.1660, P >0.05 which suggested that there was no significant difference of mean between two groups. (Table-39)
Total Effect of Therapy: Total effect of therapy has been evaluated in terms of cured, markedly improved, improved and unchanged.
TABLE-40 Table Showing Total Effect of Therapy in 20 Patients of Katishula of Group A. Sr. No. 1 2 3 4 5 6 7 8 9 10
Ave.% of Ave.% of Relief in Relief in Symptoms Signs 11.53069 16.85102 26.76834 8.838555
93.3333 3 60 46.6666 7
13.59218
50 93.3333 3 93.3333 3
14.34815
90
15.02229
100
8.936694 9.131983
50 50
9.02232
Total
Total % of Relief
104.86 4 76.851 02 73.435 01 58.838 55 102.35 57 106.92 55 104.34 82 115.02 23 58.936 69 59.131
52.4320 1 Markedly Improved 38.4255 1 Improved
107
36.7175 29.4192 8 51.1778 3 53.4627 6 52.1740 8 57.5111 5 29.4683 5 29.5659
Remarks
Improved Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved
11 12 13 14 15 16 17 18 19 20
16.09553
100
20.14396
30
14.38409
100
16.33155
100
22.03878
50
21.74125
22.05475
90 76.6666 7 93.3333 3
16.36823
40
25.02518
40
26.06156
98 116.09 55 50.143 96 114.38 41 116.33 16 72.038 78 111.74 13 102.72 82 115.38 81 56.368 23 65.025 18
9 58.0477 7 25.0719 8 57.1920 4 58.1657 8 36.0193 9 55.8706 3 51.3641 1 57.6940 4 28.1841 2 32.5125 9
Markedly Improved Improved Markedly Improved Markedly Improved Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved
TABLE-41 Table Showing Total Effect of Therapy in 20 Patients of Katishula of Group B. Sr.No. 1 2 3 4 5 6
Ave.% of Relief in Symptoms
Ave.% of Relief in Signs
14.83455
90
10.23479
90
15.89428
90
11.70406
40
32.4335
20
23.55416
36.66667
Total
Total % of Relief
Remarks
104.834 5 100.234 8 105.894 3 51.7040 6
52.4172 7 Markedly Improved
52.4335 60.2208 3
Improved
108
50.1174 52.9471 4 25.8520 3 26.2167 5 30.1104 1
Markedly Improved Markedly Improved Improved
Improved
7 8 9 10 11 12 13 14 15 16 17 18 19 20
15.66856
40
9.286239
100
10.42266
100
12.97731
90
13.38216
90
13.38523
90
6.884963
50
33.4733
16.66667
13.01946
50
11.49058
40
6.772823
93.33333
17.24505
86.66667
19.5741
36.66667
13.43026
36.66667
55.6685 6 109.286 2 110.422 7 102.977 3 103.382 2 103.385 2 56.8849 6 50.1399 7 63.0194 6 51.4905 8 100.106 2 103.911 7 56.2407 7 50.0969 3
27.8342 8 54.6431 2 55.2113 3 51.4886 5 51.6910 8 51.6926 1 28.4424 8 25.0699 8 31.5097 3 25.7452 9 50.0530 8 51.9558 6 28.1203 8 25.0484 6
Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Markedly Improved Improved Improved Improved Improved Markedly Improved Markedly Improved Improved Improved
TABLE-42 Table Showing Total Effect of Therapy in 40 Patients of Katishula Sr.No.
Total
Group A
109
Group B
Total
Effect of Therpy
No. of Pts.
%
No.of Pts.
%
No. of Pts.
%
1
Cured
0
0%
0
0%
0
0%
2
Markedly Improved
11
55%
10
50%
21
52.5%
3
Improved
09
45%
10
50%
09
47.5%
4
Unchanged
0
0%
0
0%
0
0%
In case of Group A 11 patients (55%) were markedly improved and 09 patients (45%) were improved. In case of Group B 10 patients (50%) were markedly improved and 10 patients (15%) were improved.
TABLE-43 Table Showing Comparison between Two Groups by Chi-Square Test Sr. No.
Group
Improved
110
Markedly improved
Total
Chi-square value
1
Group A
(O)=09
(O)=11
(E)=9.5
(E)=10.5
20
0.08 2
Group B
(O)=10
(O)=10
(E)=9.5
(E)=10.5
20
>0.05
Comparison between two groups was statistically evaluated by chi-square test. The value is 0.08 which was statistically insignificant which suggested that there was no significant difference between two groups with respect to therapy.
111
112
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