Nsaid Agonist Antagonist Table

Table 4: NSAID Dosing Table NSAID Celecoxib (Celebrex) Ibuprofen (Motrin) Indomethacin (Indocin) Ketorolac (Toradol) Injectable

Naproxen (Naprosyn , Anaprox) Rofecoxib (Vioxx)

Onset (hrs)

Peak (hrs) 3

Duration (hrs) 12

Usual Adult Dose & Dosing Interval 100 – 200 po BID1

Max Dose 400 mg/day1

0.5 – 1

1–2

4-6

3200 mg/day1

0.5

2

4-6

400 – 600 mg po 3 – 4 times daily1 25 – 50 mg TID1

10 mins

0.5 - 1

6–8

1

2–4

Up to 7

Use for <5 days Single Dose1: <65 yr or > 50kg: 60mg IM2 or 30mg IV >65yr or <50kg: 30mg IM2 or 15mg IV Multiple Dose1: <65 yr or > 50kg: 30 mg IM2/IV q 6 hr >65yr or <50kg: 15mg IM2/IV q 6 hr 250 – 500 mg po BID1

0.75

2–3

> 24

12.5 – 50 mg po BID1

200 mg/day Use for <5 days <65 yr or > 50kg: 120mg/24h1 >65yr or <50kg: 60 mg/24h1

1250 mg/day1

25 mg/day1 50 mg/day x 5 days1

1

Use with caution or dose adjust for renal impairment Least desired route

2

Table 5: Opioid Partial Agonist Dosing Table Use of the following in combination with mu agonists (ie., morphine, hydromorphone), may reverse analgesia and precipitate withdrawal in opioid-dependent patients. Drug

Route

Onset (min)

Peak (min)

Duration (Hrs)

Buprenorphine

IM2/SC

15

30-60

3-6

Butorphanol Nalbuphine

IM2/SC IM2/SC

15 15

30-60 30-60

3-4 3-4

1

Parenteral dose equivalent to 10 mg parenteral morphine Least desired route

2

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Usual Adult Dose & Dosing Relative Antagonist Activity Interval (mg)1 0.3 – 0.4 mg IM2/SC q 4-6 hr Potency equal to naloxone. Clinically, antagonist activity appears to be much longer than 6 hours. 2-3 mg IM2/SC q 3-4 hr 1/40 that of naloxone 10 mg IM2/SC q 3-4 hr 10 X pentazocine, which has weak antagonist activity