New Technology In Drug Delivery

New Technology in Drug Delivery

Mr.Agnimitra Dinda SPS INDIA

Drug Discovery & Development Identify disease

Human clinical trials (2-10 years)

DA

Fi IN l e D

Preclinical testing (1-3 years)

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Formulation

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Isolate protein involved in disease (2-5 years)

Find a drug effective against disease protein (2-5 years) Scale-up

FDA approval (2-3 years)

Technology is impacting this process GENOMICS, PROTEOMICS & BIOPHARM. Potentially producing many more targets and “personalized” targets

HIGH THROUGHPUT SCREENING

Screening up to 100,000 compounds a day for activity against a target protein

Identify disease

VIRTUAL SCREENING Using a computer to predict activity

Isolate protein

COMBINATORIAL CHEMISTRY Rapidly producing vast numbers of compounds

Find drug

MOLECULAR MODELING

Computer graphics & models help improve activity

IN VITRO & IN SILICO ADME MODELS

Preclinical testing

Tissue and computer models begin to replace animal testing

What is nano? Power 1012 109 106 103 10-3 10-6 10-9

Prefix tera giga mega kilo milli micro nano

Origins teras: monster gigas: giant megas: large chilioi: thousand milli: thousand mikros: small nanos: dwarf

Commercial application of NANOS: • • • • • • • • • • • • • • • •

Razor Blades Thread Lock Fasteners Fertilizers Pesticides Waste Disposal Systems Toothpaste Shampoo Bath Salts Scented Papers Extended Relief Pharmaceuticals Carbonless Paper Detergents & Bleaches Antiperspirants Air Fresheners Fire Retardants Facial Tissues

Smart Nanostructures for Selective Drug Delivery Drug Delivery for: #1 - Cardiovascular disease #2 – Cancer #3 - Infectious diseases

Nanotube Nanocap

Scale: 1/40 of red blood cell Toxin Removal for: Adverse drug reactions >106,000 deaths/yr Pesticide Poisonings >220,000 deaths/yr th

Why encapsulate materials ? • To achieve controlled/remote-release. • Make active materials easier/safer to handle. • Compartmentalize multiple component systems. • Protect sensitive materials from their environment. • To turn liquids into powders/solids. All require a specific morphology

Why Nano-Medical in India? • Targets key industries in India – Pharmaceuticals – Analytical Instruments – Medical Devices

• 3 of the 10 highest wage India industries • 3 times as many jobs exist in these industries as in India’s IT industries.

Why it is in SPS? Comprehensive university on a compact campus Institutional support and priority (2007) “…Pharmacy & biotechnology, particularly at the interface of medicine and nanoscience.” Interdisciplinary faculty with critical mass and focus

SPS NanoMedical Research Center Vision: Create and harness nano-structured material technologies for the prevention, detection and treatment of diseases in order to enhance the public health and to expand the Orissa and national economies too. Focus: Faculty: Funding: Product:

Develop nanostructures for medical diagnostics and therapeutics 140 faculty in eight academic departments >4000 students and PhD,100 supportive staff members including Hon. Vice Chancellor. State of Orissa Centers of Excellence $19.9 million for FY2003-07 with milestones Knowledge / Publications / Translational Science