Logy Course 7

TI:\IORS BENIGN AND i(ALIGNANT CON\ECTI\ E TISSUE . a.nnecrive rhsue 1!nos ae.onpos:i 'lJ:rGreniiated connective thsues oflhe e ' d''bo"'ld bod\':bor', "r,1-1" el olu' poLen_ or . .*.i. .,. o o g u. prnrleo(L

'

mezenchimal cetls

HEtoeendtr d$s ncriod oronern: ' in relation ro the tLsruc tissue Tmo$ of faiy - TMors of nbrou lissue Tumos ofskeletal od smoolh nuscLe

lsue

Tmo$ ofracnlarnssr

-

Tunor of canihgnous tl$ue Tumo6 of the bone t'$ue

Evolutive classification

TCB- benlgn connectve TCM-malignant conneciive tumors TCM arctLssue TCB are tissue proLiierations that have proliferations that lost the abi!tY to siructure and funciion ofthe iissue of orjgin TCM name is given bY TcB name is given b)/ adding the suffix adding the suffix-oma sarcoma at the the himA nr^ ifcr.iad

.

.

.

.

^f

MorphologY ir! m;d6 ddnr:ir'

rniot': to'..

Gr

5adom3: ne+v) arc

*rs

:nm., n;sses;

nq

Jrh,oLoq

'a

qrrde are

FATY TISSUE TUMORS Benignlumorsrrpoma . Lipoma s aiumor @mposed or

clal subculan*us (piorima ettr€m(ies. trunk)

suDerf

d€eo

nirafruscuLar ( srge bed tumor mass$)

.Ltumsn

.

lrlacros@pcal]y aYe ow, obu ar

'

[i croscopcally

enc?psu aleo

lumor cons stmrnq 0r marur-' adiposetssu-A and connectv+

Benign tumors-lipoma Lp.ma

s a tumorcompcseo

s!ped.e de€p

sub.uianedus

ntramusc!

a large

Lr ..osdop c"Liy endipsu ars rlmor consftnrng ormarure

Liposarcoma

nbrcUs.reawihatypica|ce[s'

LS

.:;

r-:'

:...:

,

..:1.

FIBROUS TISSUE TUMORS Mdsiands FectramalFs)

Benign tumors-fibroma (F)

thaiform short Iascicles aro!nd spird e

ce ls

may contain vessels

Fibrosarcomas - FS

Tumors of smooth muscle tissue Benisnrumors. Leionyoma (LM)

b

uni

eidd

'

Leonyo!rclia

ljsr

s

mre

nude (csarshapd)

Leiomyoma wihoul capsu e (1-2

smooth m!scle

fbe6

wlth blLrnt clrtied ends)

,{

LMS

ne'oss ai! hemohaqe (N+fo

a

t-.

d$r(iqhched en6).

Tumors of striated muscle tissue

Rabdomyoma

Embryonal RhabdomYosarcoma '

Aternating celularand

--

rndillere.uaied round or spind e cells logether wfll

{n3tuns3.e nole.l n ab.!t20 30% cas€s nlra@l u|s qLy.osei s mo,e prom neit i fre

3'1" t r.:.'

,+.

Botryoid RS E:opharyn u nan

b

ddd{aid

Alveolar RhabdomYosarcoma md iErenl aEd tumoufce s aiianged n a ateo ar patern

pdphery'g9dLpl*el4

;;.,r;'

Pleomorphic Rh a bdomyosa rco ma

Tumors of blood vessels

.

@mpose

Hemaiooma(ts)

s

llbiypei

bt rhs

defrned

s

2

d

o

Capillary Hemangioma

m*tanes r$eEl

ver

k

dne,

Hepatic cavernous hemangioma

mene'a $$da(Ns keq

Vascular tumors wlih high grade of rnalignancy

aio osarcoma (AS) s 3 Ere llmof ariiino fiom endoihe a .eLs n lhe

491'[email protected]$e'

Cartilaginous tumors crd@&rr

lsma bon*

I

enGmi'y

or

oihe

t2

Beniqn tumors - Condroma

condfosarcoma-CS

\

BONE TUMORS

BONE TUMORS

iblftolEln osddd rtsrumtr'ry

Osteosa rco m a .

rs

'

Thelumor is covered by

a arg€ rumor. wntreq6v !n coor. wnn areas olN and H sdiio!nds the metaphysrs as a co ar aesroyng. rhe adta.enl sofi i ssues

n!adjng bone matrow

Osteosarcoma

sarcomalous areas (alypi.a

-

spndreirmorc.

osleod t$ue (uim nera i:.d b.ne matxr ar.as or bone umor (m reE z€d boad

s)

Ma\ToMrs

TERATOMAS .

cassf€r011lneidrscihe

retdp'sbrea'dcrucl4oi

l\,4orphology of teratomas hish

rppdi6rts (ndue 5ob r.Bbmr d

desie

or maL qn.ncy

bulkv tumoE cdPosed rrom oredom naiiry sol d slrudures

aredfreGillarncwlh romaro^ cadaqeboneiedes.mustes

Orsr m!rp.Iel:- snrlairls dtieledalion]pGdomjEi|siolema

01

Colesteatoma (epidermoid cyst)

Epidermoid chyst cutaneous or testis location

l7

Branchial cyst

bran.haLqn wa (eprhe $ne

dii!4ri

um o,

4 h rmFdd

I!4dlu.e ovar an cystc te'aton a ,derrro d cyst)

,i1-:rc!r ni :.-, ! !:irarr

Testis mature sol t0 teratoma

fbrus tssre can a!

nous

Llalure sold teratoma

somal'lypelsues'odudig

s{ifii ,i*.:irlt,

#

lmmatufe so d teraionas

myxomaro!s svoma ano This lmmature teratoma

vELAr\OCYTjC lLrflORS

Melanocytic cells [1e

adocyl. cells a,e 3yilber2 ng

Alskjnevethemeano.lGsale

Ale2mesnocyljciypeesoE

20

Beniqn Tumots-TB=NEVI Nev orginaie from me anoc!'tes irom the epiderma basal ayer. They can be numerous ln some ndividuals. (a)congeniia r present at b rthi (b) acquired: appear dLrr ng fetime

-

neviafe pgmenied macuar lesons with cleary defned edges, slighty ra sed

Benign melanocyte tumors=nevi

MFroscopyr nevus . lo^clLonar

(

cerr

n!.

ei

a€ un

ii,aepidemrc3

)

rt9s

2l

r.Inlricpidrrnalor jo.cii0nalncvni cli.icallr-.

rs a pirrndn(ed

macula Fsion.

dd a,iolescence. \iicrosc;Ficall)..onsjst oigr.!ts olmelan!.!.s loc.red ri rh'

lr devclops in childhooa

hasal

l!\d

turd

limited

Clini.allv, 1!e! rc nodular. lale-bron lesnins. wnL itregular surfaces Ther_ rre nore fEqrendr to teenase4 ard toug adnltr Micro$pnally. :her codsnl of$oliferated melanoc)le groups lo.ared ir lhe eprdeftrh

cliiictrll], de snooth broFnpale

lesions Thr) arenore ticquen! enc.untcred Io aduhs \li.$.opi.allr. x.. co.rFos jd.a intadennal

n.!rs

cells

Compound melanocytic nevi

t2

Evolution Nev are ofien benign lesrons. but somet mes they may suffer matignant trafsformat on:

-

nlraepidermal(jonctionar) nevjor

rn

xed nev have a

isk ofconveBon from benigr io matignant esions

IVacroscopically: ihe characierisUcfeaiures of ma rgnancy for acquired nevt arel - rap o Increase Invotlme

-

li presents vaiations ofcotori

Malignant m elanoma Ma qnad mdanohas (Mlv) are

Nom3 y lonclion,l metancaB Archile{ruEr app€raice - are noma ry afanse n nesr5or

alyP'a

(psmodsm

or

fi381fl*

**w "* -'

hirdc

2l

C

utaneous ma rqnant melanoma

Cutaneous MM ft8ioctom4! ldFds ci€et

)4

Disemination MM metastasis on various ways - lymphai c way n reglonal lymph node - nematogenous way: s exp osve inio tissues and orga/rs (liver tung,

-

pancreas, digesiive traci and brain). rarely, they occurviscera metastases with strange locat ons (myocardium) whatever the place of d semination, metastases are black

2i

Melanoma of the ocular globe

t6