Lipid Lowering Drugs

  • November 2019
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LIPID LOWERING DRUGS I.

HMG- CoA reductase inhibitors / Statins • atorvastatin (Lipitor) • simvastatin (Zocor) • pravastatin MOA: inhibits HMG- CoA reductase  inhib. Cholesterol synthesis 

LDL

SE/ Adverse effects: 1. GIT upset 2. liver complications 3. rhabdomyolysis 4. cataract CI: liver failure, pregnancy & lactation, allergy to fungal byproducts II.

Bile Acid sequestrants • cholestyramine • colestipol MOA: binds bile acids in SI & promote increase disposal of cholesterol SE: 1. 2. 3. 4.

III.

CNS effects: HA, anxiety, drowsiness GIT effects: nausea ,constipation, bloating & flatulence increase bleeding muscle aches & pains

Fibrates • gemfibrozil • clofibrate MOA: decrease triglyceride & LDL synthesis 

TG & LDL,

HDL

SE: 1. same GIT effects 2. muscle aches & pains IV.

Nicotinic Acid / Vitamin B3 / Niacin MOA: 1. inhib. release of fatty acids from adipose tissue 2. increase TG removal from plasma SE: 1. intense flushing, dizziness, fainting 2. GIT effects: nausea, abdominal pain



TG & LDL,

HDL

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