LIPID LOWERING DRUGS I.
HMG- CoA reductase inhibitors / Statins • atorvastatin (Lipitor) • simvastatin (Zocor) • pravastatin MOA: inhibits HMG- CoA reductase inhib. Cholesterol synthesis
LDL
SE/ Adverse effects: 1. GIT upset 2. liver complications 3. rhabdomyolysis 4. cataract CI: liver failure, pregnancy & lactation, allergy to fungal byproducts II.
Bile Acid sequestrants • cholestyramine • colestipol MOA: binds bile acids in SI & promote increase disposal of cholesterol SE: 1. 2. 3. 4.
III.
CNS effects: HA, anxiety, drowsiness GIT effects: nausea ,constipation, bloating & flatulence increase bleeding muscle aches & pains
Fibrates • gemfibrozil • clofibrate MOA: decrease triglyceride & LDL synthesis
TG & LDL,
HDL
SE: 1. same GIT effects 2. muscle aches & pains IV.
Nicotinic Acid / Vitamin B3 / Niacin MOA: 1. inhib. release of fatty acids from adipose tissue 2. increase TG removal from plasma SE: 1. intense flushing, dizziness, fainting 2. GIT effects: nausea, abdominal pain
TG & LDL,
HDL