Lecture #15 - Cell Signaling & Signal Transduction

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Biology 301 Cellular and Molecular Biology Spring 2002

Lecture # 15: Cell Signaling & Signal Transduction

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Overall outline  Overview of signalling  Signal reception  Signal transduction

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Overview of signalling  Membrane protein functions  Local and distant cell communication  Direct communication  Overview of cell signaling

Membrane protein functions

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Local and distant cell communication

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Direct communication

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Overview of cell signaling

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Signal Reception  The functioning of a G-protein-linked receptor  The structure of a G-protein-linked receptor  The structure and function of a tyrosine-kinase receptor  Ligand-gated ion channels

The structure of a G-proteinlinked receptor

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

The functioning of a Gprotein-linked receptor

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

The structure and function of a tyrosine-kinase receptor

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Ligand-gated ion channels

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Signal transduction  A phosphorylation cascade  Cyclic AMP  cAMP as a second messenger  Calcium ion concentrations in the cell  Calcium and inositol trisphosphate in signaling

pathways  Cellular responses: Stimulation of glycogen breakdown  Nuclear response to a signal: The activation of a specific gene by a growth factor  Specificity of cell signaling

A phosphorylation cascade

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Cyclic AMP

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

cAMP as a second messenger

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Calcium ion concentrations in the cell

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Calcium and inositol trisphosphate in signaling pathways

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Cellular responses: Stimulation of glycogen breakdown

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Nuclear response to a signal: The activation of a specific gene by a growth factor

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University

Specificity of cell signaling

Ogan Gurel, MD Biology 301 Lecture # 15 Roosevelt University