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The Power of Berries Healthy Canadian Ingredients Two different species of blueberries are grown commercially in Canada.
Wild (low-bush) blueberries (i.e.Vaccinium angustifolium) are less than 20 cm
high and grow in cool climates in acidic soils while the cultivated (highbush)
Phytochemicals in brightly coloured fruits and vegetables are suggested to be the bioactive compounds associated with reduced risk of cardiovascular disease and cancer. Berry crops such as blueberries and cranberries have high concentrations of polyphenolic
blueberries (Vaccinium corymbosum) grow more than 2 meters high. Wild blue-
berries are grown in Quebec, Nova Scotia, New Brunswick, Prince Edward
Island and Newfoundland. Cultivated blueberries are grown in British Columbia.2 Berries contain a wide array of phytochemicals3—polyphenols, stilbenes,
tocopherols, carotenes and others. Of these, the polyphenols, and particularly
the anthocyanins (a flavonoid), are of interest as they give the intense colour to many fruits and vegetables, such as blueberries, cranberries, red cabbages
and purple potatoes, and contribute substantially to their antioxidant capacity.
compounds, vitamins and minerals.
Health Benefits Canada is the second largest producer of cranberries (Vaccinium macrocarpon) in the world,1 with production in British Columbia, Quebec, Nova Scotia, New Brunswick and Ontario.
Polyphenolic antioxidants are considered premier disease fighters that
protect the body against free radicals or unstable molecules that cause cell
damage leading to chronic and degenerative diseases.4 Most dark coloured fruits have a high antioxidative capacity.5,6
Cranberries contain proanthocyanidins (PACs) which prevent the adhesion of bacteria to cell walls,7,8 potentially reducing risk of bacterial infections.9 This is the proposed mechanism for the positive association between cranberries and urinary tract health,10 its ability to inhibit stomach ulcers caused by
Helicobacter pylori,11,12 and its protective effect for gums and teeth against
cavity formation and gum disease.13,14
Canadian researchers have shown a blueberry-rich diet may improve stroke
outcomes in rats15 and that blueberry and cranberry proanthocyanidins may
assist in controlling tumor formation in some cancers.16, 17 A recent study
showed wild blueberry polyphenolic compounds were active against all stages of cancer—initiation, promotion and proliferation.18, 19 Another investigation
is looking into the health potential of berry processing waste products
(i.e. residual meal after juice processing). Researchers at the University of Western Ontario have determined that a cranberry meal extract may be a novel anticancer agent.4
Cranberries and blueberries may also impact cardio-
Canadian Research Expertise
terol from the blood and inhibiting the oxidation of
Agriculture and Agri-Food Canada
focused on the anti-inflammatory properties of
(St. Hyacinthe, QC)
vascular health by enhancing the removal of choleslow-density lipoproteins.20-22 Recently attention has
flavonoid polyphenolics and their positive contribution to overall health.23
Berries and their isolated active compounds have
been shown to exhibit potentially beneficial effects in diabetes24, memory enhancement,25 radiation
protection,26 and as an anti-influenza agent.14
A new addition to
Canada’s production is the Saskatoon berry
(Amelanchier alnifolia),
a deep blue-purple tree berry. Primarily grown on the Canadian
prairies, fresh, frozen
and processed products are sold throughout Canada, the U.S. and the United Kingdom. Research on the antioxidative capacity and potential health benefits of this fruit is just beginning.27
Innovative Applications
Blueberries and cranberries are processed into jams,
jellies, drinks, concentrates, purees, juices and syrups, pie fillings and sauces. They are canned and frozen in
both retail and wholesale packs. Fresh, frozen and dried
• Food Research and Development Centre – Improving the process to dry cranberries and blueberries (M. Marcotte)
• Atlantic Food and Horticulture Research Centre (AFHRC) (Kentville, NS):
– Developing technology to improve sustainable production and quality of wild blueberries (K MacKenzie)
– Studying blueberry chemistry, human health bioactives of fruit polyphenolics, polyphenolic
separation, health-related bioassays, animal and human studies (W. Kalt)
• Pacific Agri-Food Research Centre (Summerland-
Agassiz, BC)
– Discover, extract, concentrate/isolate, and characterize flavonoids from selected fruits, vegetables and grains; 2) determine the
antioxidant and anti-inflammatory activities of
flavonoid-rich extracts and/or purified/concentrated compounds and their metabolites; and, 3) develop and commercialize, with industry
partners, products rich in flavonoids (G. Mazza)
– Behavioural ecology, pheromone communication and integrated pest management of blueberry and cranberry pests (S. Fitzpatrick)
blueberries and cranberries are used in bakery products,
Atlantic Canada Network on Bioactive Compounds
Berry extracts are used as colouring and flavouring
tions for products recovered from wild blueberries
nutrition bars, trail and snack mixes, cereals and muesli. agents, and dried concentrated extracts are being
packed into capsules for sale as natural health products.
(Charlottetown, PEI) (pursuing commercial applica-
and wild rosehips)
– Purification and analysis of blueberry bioactive fractions (W. Kalt,)
– Demonstration of health-promoting activity of
specific blueberry fractions (M. Sweeney-Nixon, K. Gottschall-Pass, S. MacKinnon)
– Effect of blueberry bioactives on gene expression (C. Nelson)
July 2006
The Power of Berries
2
Institute of Functional Foods and Nutraceuticals (INAF) (St. Foy, QC).
– Studying the effect of natural antioxidants (from small fruits) and oxidative stress on the central
nervous system and neurodegenerative diseases
10. Prairie Lane Saskatoons Inc (Petersfield, MB) [email protected]
11. Quebec Wild Blueberries Inc (Les Bleuets
Sauvages du Québec (Saint-Felicien, QC) http://www.wild-blueberries.com
like Alzheimers, and Parkinsons (C. Ramassamy)
12. Rainbow Farms (Upper Rawdon, NS)
(i.e. cranberries) on cardiovascular disease
13. Vaccinium Technologies Inc. (Fredericton, NB)
– Effect of dietary antioxidant supplementation indicators (C. Couillard)
http://www.rainbowfarms.ns.ca
http://www.bioatlantech.nb.ca/business_
– Antioxidant capacity of cranberries (J. Makhlouf) University of Moncton (Moncton, NB): Functional Foods Laboratory
– Optimizing the extraction of flavonoids from
small fruits, such as blueberries and cranberries (C. Matar)
University of Western Ontario (London, ON)
– Investigating new products (i.e. cranberry flavonoid extracts) for their potential use as anticancer agents (P.J. Ferguson)
Canadian Suppliers
1. British Columbia Blueberry Council
vaccinium.html
References
1. Foreign Agricultural Service, USDA GAIN Report #CA1144. 2001. Canadian Cranberries.
2. Agriculture and Agri-Food Canada. 2004. 1. http://www.agr.gc.ca/misb/hort/sit/pdf/fru_ 3
02_03_e.pdf
Prior, L. et al, 1998. J. Agric.Food Chem. 46:2686-2993.
4. Hoelzl, C. et al., 2005. J. Physiol. Pharmacol.52, Supp.2: 49-64.
5. Kalt, W. et al., 1999. J. Food Sci. 65:390-393 6. Kalt, W. et al., 2001. J. Agric. Food Chem. 49:4761-4767.
(Abbottsford, BC) http://www.bcblueberry.com
7. Liu, R.H. et al. Biotechnol. Bioeng. 93:297-305
(Abbottsford, BC)
9. Sharon, N and I. Ofek. 2002. Crit. Rev. Food Sci.
2. British Columbia Cranberry Growers Association http://www.bccranberrygrowers.com
3. Atoka Cranberries Inc. (Manseau, QC) http://www.atoka.qc.ca
4. Johnson’s Cranberry Marsh (Bala, ON) http://www.cranberry.ca
5. Fruit d’Or (Notre-Dame de Lourdes, QC) http://www.fruit-dor.ca
8. Leitao, D.P., et al, 2005. J. Med. Food8:36-40. Nutr. 42:291-299
10. Foo, L.Y. et al, 2000. Phytochemistry 54:173-181. 11. Burger et al., 2002. Crit. Rev. Food Sci. Nutr. 42:279-284.
12. Chatterjee, A. et al., 2004. Mol. Cell Biochem. 265-19-26.
6. Jasper Wymen and Son Canada Inc. (Morell, PEI) http://www.wymans.com
7. Les Bleuets Mistassini Ltee (Dolbeau-Mistassini, QC http://www.bleuets-mistassini.com
8. Nova Agri Inc. (Centreville, NS) http://www.novaagri.com
9. Oxford Frozen Foods Limited (Oxford, NS) http://www.oxfordfrozenfoods.com/
Courtesy of Dairy Farmers of Canada
July 2006
The Power of Berries
3
13. Weis, E.I. et al., 2004. Crit. Rev. Food Sci. Nutr. 42:285-292.
14. Weis, E.I. et al., 2005. Antiviral Res. 66:9-12. 15. Sweeney, M. et al., 2002. Nutr. Neurosci. 5:427-431.
16. Matchett, M.D. et al., 2005. Biochem. Cell Biol. 83:637-643.
17. Murphy, B. T. et al., 2003. J. Agric. Food Chem. 51:3541-3545.
18. Hou, D.X. 2003. Curr. Mol. Med. 3:149-159.
19. Kraft, T.F.B. et al., 2005. J. Food Sci. 70:S159-166. 20. Chu, Y.F and R. H. Liu. 2005. Life Sci. 77:1892-1901.
21. Reed. J. 2002. Crit. Rev. Food Sci. Nutr. 42 (supp): 301-316.
22. Rimando, A.M et al., 2004. R J. Agric. Food Chem. 52:4713-4719.
23. Manthey, J.A. 2000. Microcirculation. 7:S29-34
24. Chambers, B.K. and M.E. Camire. 2003. Diabetes Care. 26: 2695-2696.
25. Andres-Lacueva, C. et al., 2005. Nutr. Neurosci. 8:111-120.
26. Rabin, B. M. et al., 2005. Gravit.Space Biol. Bull. 18:71-77.
27. Wang. J. and G. Mazza. 2002. J. Agric.Food Chem. 26: 2695-2696.
Author: C.A. Patterson, The Pathfinders Research & Management Ltd
July 2006
The Power of Berries
4
AAFC No. 10078E
Wild (low-bush) blueberries (i.e.Vaccinium angustifolium) are less than 20 cm
high and grow in cool climates in acidic soils while the cultivated (highbush)
Phytochemicals in brightly coloured fruits and vegetables are suggested to be the bioactive compounds associated with reduced risk of cardiovascular disease and cancer. Berry crops such as blueberries and cranberries have high concentrations of polyphenolic
blueberries (Vaccinium corymbosum) grow more than 2 meters high. Wild blue-
berries are grown in Quebec, Nova Scotia, New Brunswick, Prince Edward
Island and Newfoundland. Cultivated blueberries are grown in British Columbia.2 Berries contain a wide array of phytochemicals3—polyphenols, stilbenes,
tocopherols, carotenes and others. Of these, the polyphenols, and particularly
the anthocyanins (a flavonoid), are of interest as they give the intense colour to many fruits and vegetables, such as blueberries, cranberries, red cabbages
and purple potatoes, and contribute substantially to their antioxidant capacity.
compounds, vitamins and minerals.
Health Benefits Canada is the second largest producer of cranberries (Vaccinium macrocarpon) in the world,1 with production in British Columbia, Quebec, Nova Scotia, New Brunswick and Ontario.
Polyphenolic antioxidants are considered premier disease fighters that
protect the body against free radicals or unstable molecules that cause cell
damage leading to chronic and degenerative diseases.4 Most dark coloured fruits have a high antioxidative capacity.5,6
Cranberries contain proanthocyanidins (PACs) which prevent the adhesion of bacteria to cell walls,7,8 potentially reducing risk of bacterial infections.9 This is the proposed mechanism for the positive association between cranberries and urinary tract health,10 its ability to inhibit stomach ulcers caused by
Helicobacter pylori,11,12 and its protective effect for gums and teeth against
cavity formation and gum disease.13,14
Canadian researchers have shown a blueberry-rich diet may improve stroke
outcomes in rats15 and that blueberry and cranberry proanthocyanidins may
assist in controlling tumor formation in some cancers.16, 17 A recent study
showed wild blueberry polyphenolic compounds were active against all stages of cancer—initiation, promotion and proliferation.18, 19 Another investigation
is looking into the health potential of berry processing waste products
(i.e. residual meal after juice processing). Researchers at the University of Western Ontario have determined that a cranberry meal extract may be a novel anticancer agent.4
Cranberries and blueberries may also impact cardio-
Canadian Research Expertise
terol from the blood and inhibiting the oxidation of
Agriculture and Agri-Food Canada
focused on the anti-inflammatory properties of
(St. Hyacinthe, QC)
vascular health by enhancing the removal of choleslow-density lipoproteins.20-22 Recently attention has
flavonoid polyphenolics and their positive contribution to overall health.23
Berries and their isolated active compounds have
been shown to exhibit potentially beneficial effects in diabetes24, memory enhancement,25 radiation
protection,26 and as an anti-influenza agent.14
A new addition to
Canada’s production is the Saskatoon berry
(Amelanchier alnifolia),
a deep blue-purple tree berry. Primarily grown on the Canadian
prairies, fresh, frozen
and processed products are sold throughout Canada, the U.S. and the United Kingdom. Research on the antioxidative capacity and potential health benefits of this fruit is just beginning.27
Innovative Applications
Blueberries and cranberries are processed into jams,
jellies, drinks, concentrates, purees, juices and syrups, pie fillings and sauces. They are canned and frozen in
both retail and wholesale packs. Fresh, frozen and dried
• Food Research and Development Centre – Improving the process to dry cranberries and blueberries (M. Marcotte)
• Atlantic Food and Horticulture Research Centre (AFHRC) (Kentville, NS):
– Developing technology to improve sustainable production and quality of wild blueberries (K MacKenzie)
– Studying blueberry chemistry, human health bioactives of fruit polyphenolics, polyphenolic
separation, health-related bioassays, animal and human studies (W. Kalt)
• Pacific Agri-Food Research Centre (Summerland-
Agassiz, BC)
– Discover, extract, concentrate/isolate, and characterize flavonoids from selected fruits, vegetables and grains; 2) determine the
antioxidant and anti-inflammatory activities of
flavonoid-rich extracts and/or purified/concentrated compounds and their metabolites; and, 3) develop and commercialize, with industry
partners, products rich in flavonoids (G. Mazza)
– Behavioural ecology, pheromone communication and integrated pest management of blueberry and cranberry pests (S. Fitzpatrick)
blueberries and cranberries are used in bakery products,
Atlantic Canada Network on Bioactive Compounds
Berry extracts are used as colouring and flavouring
tions for products recovered from wild blueberries
nutrition bars, trail and snack mixes, cereals and muesli. agents, and dried concentrated extracts are being
packed into capsules for sale as natural health products.
(Charlottetown, PEI) (pursuing commercial applica-
and wild rosehips)
– Purification and analysis of blueberry bioactive fractions (W. Kalt,)
– Demonstration of health-promoting activity of
specific blueberry fractions (M. Sweeney-Nixon, K. Gottschall-Pass, S. MacKinnon)
– Effect of blueberry bioactives on gene expression (C. Nelson)
July 2006
The Power of Berries
2
Institute of Functional Foods and Nutraceuticals (INAF) (St. Foy, QC).
– Studying the effect of natural antioxidants (from small fruits) and oxidative stress on the central
nervous system and neurodegenerative diseases
10. Prairie Lane Saskatoons Inc (Petersfield, MB) [email protected]
11. Quebec Wild Blueberries Inc (Les Bleuets
Sauvages du Québec (Saint-Felicien, QC) http://www.wild-blueberries.com
like Alzheimers, and Parkinsons (C. Ramassamy)
12. Rainbow Farms (Upper Rawdon, NS)
(i.e. cranberries) on cardiovascular disease
13. Vaccinium Technologies Inc. (Fredericton, NB)
– Effect of dietary antioxidant supplementation indicators (C. Couillard)
http://www.rainbowfarms.ns.ca
http://www.bioatlantech.nb.ca/business_
– Antioxidant capacity of cranberries (J. Makhlouf) University of Moncton (Moncton, NB): Functional Foods Laboratory
– Optimizing the extraction of flavonoids from
small fruits, such as blueberries and cranberries (C. Matar)
University of Western Ontario (London, ON)
– Investigating new products (i.e. cranberry flavonoid extracts) for their potential use as anticancer agents (P.J. Ferguson)
Canadian Suppliers
1. British Columbia Blueberry Council
vaccinium.html
References
1. Foreign Agricultural Service, USDA GAIN Report #CA1144. 2001. Canadian Cranberries.
2. Agriculture and Agri-Food Canada. 2004. 1. http://www.agr.gc.ca/misb/hort/sit/pdf/fru_ 3
02_03_e.pdf
Prior, L. et al, 1998. J. Agric.Food Chem. 46:2686-2993.
4. Hoelzl, C. et al., 2005. J. Physiol. Pharmacol.52, Supp.2: 49-64.
5. Kalt, W. et al., 1999. J. Food Sci. 65:390-393 6. Kalt, W. et al., 2001. J. Agric. Food Chem. 49:4761-4767.
(Abbottsford, BC) http://www.bcblueberry.com
7. Liu, R.H. et al. Biotechnol. Bioeng. 93:297-305
(Abbottsford, BC)
9. Sharon, N and I. Ofek. 2002. Crit. Rev. Food Sci.
2. British Columbia Cranberry Growers Association http://www.bccranberrygrowers.com
3. Atoka Cranberries Inc. (Manseau, QC) http://www.atoka.qc.ca
4. Johnson’s Cranberry Marsh (Bala, ON) http://www.cranberry.ca
5. Fruit d’Or (Notre-Dame de Lourdes, QC) http://www.fruit-dor.ca
8. Leitao, D.P., et al, 2005. J. Med. Food8:36-40. Nutr. 42:291-299
10. Foo, L.Y. et al, 2000. Phytochemistry 54:173-181. 11. Burger et al., 2002. Crit. Rev. Food Sci. Nutr. 42:279-284.
12. Chatterjee, A. et al., 2004. Mol. Cell Biochem. 265-19-26.
6. Jasper Wymen and Son Canada Inc. (Morell, PEI) http://www.wymans.com
7. Les Bleuets Mistassini Ltee (Dolbeau-Mistassini, QC http://www.bleuets-mistassini.com
8. Nova Agri Inc. (Centreville, NS) http://www.novaagri.com
9. Oxford Frozen Foods Limited (Oxford, NS) http://www.oxfordfrozenfoods.com/
Courtesy of Dairy Farmers of Canada
July 2006
The Power of Berries
3
13. Weis, E.I. et al., 2004. Crit. Rev. Food Sci. Nutr. 42:285-292.
14. Weis, E.I. et al., 2005. Antiviral Res. 66:9-12. 15. Sweeney, M. et al., 2002. Nutr. Neurosci. 5:427-431.
16. Matchett, M.D. et al., 2005. Biochem. Cell Biol. 83:637-643.
17. Murphy, B. T. et al., 2003. J. Agric. Food Chem. 51:3541-3545.
18. Hou, D.X. 2003. Curr. Mol. Med. 3:149-159.
19. Kraft, T.F.B. et al., 2005. J. Food Sci. 70:S159-166. 20. Chu, Y.F and R. H. Liu. 2005. Life Sci. 77:1892-1901.
21. Reed. J. 2002. Crit. Rev. Food Sci. Nutr. 42 (supp): 301-316.
22. Rimando, A.M et al., 2004. R J. Agric. Food Chem. 52:4713-4719.
23. Manthey, J.A. 2000. Microcirculation. 7:S29-34
24. Chambers, B.K. and M.E. Camire. 2003. Diabetes Care. 26: 2695-2696.
25. Andres-Lacueva, C. et al., 2005. Nutr. Neurosci. 8:111-120.
26. Rabin, B. M. et al., 2005. Gravit.Space Biol. Bull. 18:71-77.
27. Wang. J. and G. Mazza. 2002. J. Agric.Food Chem. 26: 2695-2696.
Author: C.A. Patterson, The Pathfinders Research & Management Ltd
July 2006
The Power of Berries
4
AAFC No. 10078E
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