Granulomatous Lesions Of Nose

Granulomatous lesions of nose and paranasal sinuses By Dr. T. Balasubramanian M.S. D.L.O.

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Definition: Many chronic inflammations involving the nose and paranasal sinuses are characterized by formation of granulation tissue infiltrated by chronic inflammatory cells. These lesions also are known as granulomata. Majority of these granulomata are caused by specific infectious organism and hence known as "Specific granulomata". While in others, the etiology is not clearly evident and is hence known as "Non specific granulomata" or more commonly “Midline non healing granulomata". Diagnosis of these lesions is only possible by histological examination / microbiological examination of the lesion. Histologically, the principal components of any granulomatous lesion are considered to be macrophages, epithelioid cells and multinucleated giant cells. Necrosis and vasculitis could also be seen in varying degrees. The role of previous therapy should also be considered as they could very well have modified the lesions. *Caution: Many of granulomatous lesions of nose and PNS do not show these features.

Classification of Nasal granulomas: Specific: 1. Tuberculosis 2. Leprosy 3. Syphilis 4. Yaws 5. Scleroma 6. Actinomycosis 7. Aspergillosis 8. Mucormycosis 9. Rhinosporidiosis 10. Leishmaniasis

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11. AIDS

Nonspecific: 1. Sarcoidosis 2. Wegner's granulomatosis 3. Sinonasal lymphoma 4. Eosinophilic granuloma

Tuberculosis: Tuberculous lesions involving nasal mucosa is very rare. It is always associated with primary pulmonary tuberculosis. Macroscopic appearance: 1. Ulcers 2. Polypoidal lesions 3. Nodular lesions Ulcers are commonly found on the anterior part of the nasal septum, inferior turbinate and anterior choanae. Lupus vulgaris: This is an indolent and chronic from of tuberculous infection affecting the skin and mucous membrane of nose. It is two times more common in women than in men... It is known to affect young adults. It is infact a disease of temperate climate and is rare in tropics. The mucocutaneous junction of the nasal septum is the most common location of these lesions. This could also very well be the site of inoculation, as it is more exposed to trauma in patients with the habit of nose picking. Nasal lesions are frequently associated with or could be considered to be precursor to nodules on the face. Histopathology: Sections of these lesions show the classic features of tuberculous granuloma. In the centre these lesions show collection of reticuloendothelial cells. These cells soon necrose

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and coalesce. This necrotic centre is surrounded by a ring of living RE cells. Around this ring of living reticuloendothelial cells is a ring of lymphocytes, plasma cells and fibroblasts. Giant cells are found scattered throughout the tubercle and are usually multinucleated. Symptoms: 1. Nasal discharge / obstruction 2. Presence of non foul smelling crusts 3. Epistaxis 4. When there is ulceration then there could be mild fetor Ulceration of nasal mucosa is usually followed by fibrosis and contraction causing distortion of alae nasi. If turbinates are involved extensively, the lining ciliated columnar epithelium is not renewed. This could lead on to the formation of secondary atrophic rhinitis. The typical early lesion in the nose is a reddish firm nodule at the mucocutaneous junction of the nasal septum. These nodules are known as “Apple jelly nodules” since they resemble apple jelly in their appearance. In advanced cases of lupus the floor of the nasal cavity and turbinates can also be involved, the spread usually occurring in a backward direction from the primary site. Septum may also undergo perforation, but in these cases classically the cartilaginous portion alone is involved and hence there is no sinking of the nasal bridge. This is in stark contrast to syphilitic involvement of nasal septum where in destruction is confined only to the bony portion of the nasal septum, with an intact cartilaginous portion. In leprosy both bony and cartilaginous portions of nasal septum is destroyed associated with sinking of nasal bridge. Lupus is also known to cause extensive scarring of the vestibule leading on to its distortion. Sometimes the nodules may also extend to the skin of the face. Diagnostic features of Lupus nodules: 1. Blanching 2. Bacterial examination 3. Biopsy To highlight the apple jelly nodules, blood should be expressed from adjoining tissues by applying pressure with a glass slide, this will make the pinkish lupus nodules to standout in contrast. Bacteriological examination may demonstrate AFB. Biopsy is always diagnostic. Complications: 1. Dacryocystitis 2. Lupus of face 3. Atrophic rhinitis 4. Development of epithelioma (rare sequlae)

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Sudden increase in size and hardness of the node in an elderly with an increasing tendency to bleed should arouse the suspicion of epithelioma formation. Biopsy is an absolute indication in these cases. Treatment: This condition responds well to antituberculous drugs. After the disease is arrested surgical repair of the deformed nose can be carried out. Leprosy: This is a chronic granulomatous disease caused by M. Leprae. This bacterium is more or less morphologically similar to M. Tuberculi. Types of leprosy: Tuberculoid leprosy: are solitary lesions (anesthetic patches) with associated involvement of one / more related sensory or motor nerves. This could lead on to paralysis of muscles. Skin lesions may extend up to the nasal vestibule. This type of lesion falls short without involving the nasal mucosa. Isolated cranial nerve palsies have also documented in this type of leprosy. Immunologically, these patients demonstrate excellent resistance to L. Leprae bacilli. Lepromatous leprosy: In this type of leprosy there is diffuse infiltration of skin, nerves and mucosal surfaces by the bacteria. These patients have the least immunological resistance to the organism. Cutaneous infiltration is more common over the edges of pinna, chin, nose and eyebrows because these areas have a temperature lesser than that of core temperature. These patients are considered to be highly infectious, as their nasal discharges contain potentially infectious lepra bacilli. Commonly the affected nose has crust formation, nasal obstruction and Serosanguinous discharge. The earliest sign of nasal mucosal involvement is the presence of nodular thickening of nasal mucosa. These nodules are paler than the surrounding mucosa with a yellowish tinge. These lepra nodules commonly begin at the anterior end of inferior turbinate, it then progresses to gross inflammation of nasal mucosa. Nasal obstruction is out of proportion to that of degree of nasal mucosal involvement. This is due to the fact that the nasal valve area is commonly affected. Both the bony and cartilaginous portions of nasal septum are destroyed due to perichondritis and periosteitis. Nasal bridge collapse is commonly seen in these patients. Anterior nasal spine is commonly destroyed in these patients. Radiographs showing the absence / erosion of anterior nasal spine are virtually diagnostic of Lepromatous leprosy. Diagnosis can always be confirmed by studying the scrapings of nasal mucosa. They demonstrate the typical cigar pattern Lepra bacilli. Commonly positive scrapings can be obtained from the anterior end of inferior turbinate. Borderline leprosy: These patients have poor immunological resistance. They may hence progress to Lepromatous type. Skin lesions are more numerous and are seen

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around eyes, nose and mouth. In pure borderline lesions involvement of nasal mucosa is not seen. If nasal mucosal involvement is demonstrated than it will have to be assumed that the lesion has progressed to Lepromatous stage. Treatment: Dapsone is the sheet anchor drug used in the management of leprosy. It virtually reduces the bacilli count of nasal discharge to zero or near zero within a couple of months. Modern drugs like rifampicin and clofazimine can reduce the bacilli count to zero within 10 days. Triple therapy: 1. Rifampicin – 600mg on first two days of a month taken before breakfast 2. Clofazimine – 100mg on alternate days for three times a week 3. Dapsone – 100 mg a day These drugs are continued for 3 months after which Rifampicin is stopped. Other two drugs are continued till 9 months are completed. Nasal douching with saline will help in removal of crusts. Syphilis: Nasal syphilis can affect any age group. Histopathology: Diagnosis is purely histopathological. It is characterized by oedema, stromal infiltration with lymphocytes, plasma cells and endothelial cells. Perivascular cuffing by these cells and endarteritis will cause a reduction in the lumen of blood vessels causing necrosis and ulceration. Nasal syphilis can be classified into: 1. Primary syphilis 2. Secondary syphilis 3. Tertiary syphilis Primary syphilis: Also known as chancre can occur at the external nose or inside the vestibule. It appears as a hard, non painful ulcerated papule always associated with enlarged, rubbery, and non tender lymphadenopathy. This condition always occurs within the first month of contact. There may also be associated systemic features like fever and malaise. These lesions undergo spontaneous resolution within 6-10 weeks.

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The following points should be borne in mind: 1. Cultures from the surface of the lesion will always be negative 2. Smears when examined under dark ground illumination will show the spirochete Treponema palladium 3. Serological tests for syphilis may be positive – VDRL, TPHA, FTA-ABS 4. A biopsy from suspicious lesion may confirm the diagnosis This condition should be differentiated from malignant neoplasms and furunculosis. Malignant neoplasms are relentless in their progression, and affect older age group patients. Furunculosis is rather painful condition. These patients will respond to antisyphilitc treatment. I.e. Intramuscular injections of penicillin. Secondary syphilis: This is the most infectious of all the three stages of syphilis. Symptoms usually occur appear 6-10 weeks after inoculation. The symptoms include: 1. 2. 3. 4. 5.

Simple catarrhal rhinitis (persistent) Crusting & fissuring of nasal vestibule Other secondary lesions like mucous patches in the pharynx are also seen Roseolar / papular skin rashes Enlarged non tender lymph nodes.

Serological tests for syphilis are positive. These patients respond to antisyphilitic drugs Tertiary syphilis: This stage is commonly encountered in the nose. The lesion is also known as gumma. This lesion invades the mucous membrane, periosteum and bone. The bony portion of the nasal septum is frequently affected causing septal perforation. Rarely the following portions of the nose can also be involved: 1. 2. 3. 4.

Lateral nasal wall Frontal sinus Nasal bones Floor of the nose

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Symptoms include: 1. Pain / headache (worse during night) 2. Swelling / obstruction of nose - swelling may be diffuse / localized associated with offensive discharge, bleeding and crusting of the nose 3. Olfactory acuity diminishes 4. Perforation of bony portion of nasal septum associated with collapse of the bridge of the nose can cause structural damage to the nasal architecture 5. There may also be associated secondary atrophic rhinitis 6. The lesion is usually unilateral, but if septum is involved then swelling may be present in both sides of the nasal cavity. 7. Tenderness over the bridge of the nose is a characteristic sign The following points aids in the diagnosis: 1. 2. 3. 4.

The swollen nasal mucosa does not shrink when vasoconstrictors are used Radiographs show rarefaction of bone with blurring of the cortical outline Serological tests for syphilis are positive in a vast majority of cases Biopsy from the lesion is diagnostic

Nasal complications of gumma: 1. 2. 3. 4. 5. 6. 7.

Secondary infections with pyogenic organisms Sequestration Perforation of bony portion of nasal septum, palate or nasal walls Collapse of bridge of nose with deformity of nose Scarring / stenosis of nasal passages Atrophic rhinitis Intracranial complications due to involvement of meninges

Treatment is administration of antisyphilitic drugs. Congenital syphilis “Snuffles”: In congenital syphilis any of the lesions of secondary and tertiary forms of syphilis of nose can occur. In infants these lesions classically begin during the 3rd week of life. These lesions may also appear even as late as 3 months of life. At first snuffles appear as simple catarrhal rhinitis. In very short time it becomes purulent with secondary fissuring and excoriation of the nasal vestibule and upper lip.

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Since infants are obligate nasal breathers, the obstruction may even lead to feeding problems. Serologic tests for syphilis will invariably be negative. Priority should be given to the management of nasal obstruction in these patients. Yaws: This condition is also known as “Framboesia”. This disease infact closely resembles syphilis in its pathology. This lesion is widespread in central Africa, Jamaica and Philippines. Causative organism: Treponema Pertenue. Morphologically this organism is indistinguishable from Treponema pallidum. Transmission: Is by direct extra genital contact. It has a high incidence in infancy and childhood. Clinical features: Primary, secondary and tertiary stages occur as in syphilis. Yaws characteristically affects principally the skin. Mucous membrane are usually spared but for the mucocutaneous junctions. Advance nasal lesions are associated with extensive destruction of the nose, palate etc. Destruction also may involve the whole of the maxilla, face and pharynx. In yaws the serologic tests for syphilis is positive. These lesions characteristically respond to conventional antisyphilitic treatment.

Rhinoscleroma: “Scleroma” This is a progressive granulomatous lesion beginning in the nose and eventually extending into the Nasopharynx and oropharynx. Rarely larynx, trachea and lower air way may also be involved. Scleroma may occur at any age. Both sexes may equally be affected. This disease is common in central and south eastern Europe, North Africa, Pakistan and Indonesia. One common factor seen in these patients is – poor standard of life and oral hygiene.

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Pathology: Organism causing this disorder is Klebsiella Rhinoscleromatis. This organism could be a secondary invader following a viral infection. Granulomatous tissue infiltrates the submucosa and is characterized by the presence of an accumulation of plasma cells, lymphocytes and eosinophils among which are scattered large foam cells (Mikulicz cells). These foam cells have a central nucleus, and a vacuolated cytoplasm containing the bacilli. Russell bodies have also been demonstrated. These cells resemble plasma cells and have eccentric nucleus with deep staining cytoplasm. Investigations: Levin test: This is a complement fixation test, based on the reaction of the patient’s serum with suspensions of K. Rhinoscleromatis. High titres of antibodies against K. Rhinoscleromatis has been demonstrated. This indicates humoral immunity to be intact in these patients. Clinical features: Three different stages have been documented: 1. Atrophic stage: In this stage changes appear in the nasal mucous membrane. These changes resemble that of atrophic rhinitis. Foul smelling crusts are seen. 2. Granulation / nodular stage: Nodules are non ulcerative in nature. Initially these nodules are bluish red and rubbery. Later these nodes become a little paler and harder. 3. Cicatrizing stage: Adhesions and stenosis distort the normal nasal anatomy. The shape and contour of the nose changes causing a condition known as “Tapir’s nose”. The disease may extend to involve the maxillary sinus, naso lacrimal duct, Nasopharynx, trachea and bronchi. Lymphatic spread is uncommon because of extensive fibrous tissue deposition. This deposition blocks the lymphatics. Treatment: Diagnosis is confirmed by biopsy. Bactericidal antibiotics should be administered in large doses. It should be administered atleast for a period of 4-6 weeks. Surgical debridement should be considered when extensive cicatrization is present.

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Aspergillosis: This is the commonest fungal infection involving the nose and paranasal sinuses. Causative organism: 1. Aspergillus fumigatus – 90% of cases 2. Aspergillus Niger / flavus – 10%

Non specific granulomas: These granulomas belong to the unknown etiology. Sarcoidosis: This granulomatous lesion is a systemic condition of unknown etiology. This may affect any part of the body. It may be found anywhere in the world. Definition: Scadding and Mitchell defined Sarcoidosis as a disease characterized by formation in all of the several affected organs / tissues of epitheloid tubercles, without caseation. These granules either resolve on their own or get converted into hyaline fibrous tissue. Age and sex distribution: Sarcoidosis is a condition commonly affecting young adults, commonly between their 3rd and 5th decades of life. Females out number males by a ratio of 2:1. Etiology: Etiology is unknown. Various theories have been proposed. 1. 2. 3. 4.

Infective agents (? Viral) Chemical (Beryllium & Zirconium) Pine pollen Pea nut dust

Immunology in patients with Sarcoidosis: 1. 2. 3. 4. 5.

Type IV delayed hypersensitivity is depressed Cell mediated immunity is normal Type I humeral immunity is normal Total plasma protein levels are raised There is an increase in the amount of circulating immune complexes

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6. One theory suggests that pathogenesis of sarcoid could be due to a process initiated by an antigen presenting cell causing IL-1 and IL-2 driven T cell proliferation. Monocytes are attracted from the blood by monocyte chemotactic factor (IL-8), and are held at the site of reaction by macrophage migration inhibition factor. The persistence of granuloma may be ascribed to continued antigenic stimulation, failure of suppressor / regulating mechanisms / abnormalities in the regulation of the cytokine network. Histology: Sarcoid granuloma is characterized by epitheloid cells surrounded by lymphocytes and fibroblasts, but there is no caseation. Crystalline / calcified inclusion bodies are sometimes seen. These bodies are known as Schaumann bodies. These granulomas are not diagnostic as similar ones can occur in fungal diseases and berylliosis. Clinical features: 1. 2. 3. 4. 5. 6. 7.

Nasal stuffiness / obstruction Crusting Blood stained discharge Purulent discharge Facial pain Mucoid discharge Anosmia

Nasal cavity mucosa has a characteristic granular appearance (i.e. also called as strawberry skin). Pale tiny granulomas could be seen studding the nasal mucosa, giving it a strawberry like appearance. Nasal mucosa in general would be hyperemic. The nasal mucosa becomes very friable leading on to blood stained discharge. There may also be crusting of the nasal mucosa associated with mucopurulent discharge. The anterior portion of the nasal septum may perforate, especially if traumatized for example during surgery. (Beware of performing septal surgery in a patient with Sarcoidosis of nose). Nasal bones can also be involved, causing expansion of the bridge of the nose associated with thickening and discoloration of the overlying skin (i.e. Lupus pernio). Sense of smell may be affected due to mechanical obstruction of the olfactory cleft by crusting and fibrosis, or due to direct neuropathy. Adenoid enlargement may lead to middle ear effusion.

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Diagnosis: Is by a combination of histology, imaging, hematology and clinical acumen. 1. Kveim test: This is a skin test which helps in the diagnosis of Sarcoidosis. (Something like tuberculin test). This test is performed by intradermal injection of a filtered extract of spleen from a patient with sarcoid. Six weeks later a skin biopsy is taken. The test is positive when the histology shows features of Sarcoidosis. 2. Angiotensin converting enzyme is found to be elevated in patients during acute phase of the disease 3. ESR levels are raised 4. X-ray chest will identify pulmonary lesions Treatment: Some patients may be lucky enough to have the benefit of spontaneous resolution. Majority of the patients are treated with a combination of oral steroids, methotrexate and hydroxychloroquine. The treatment modality depends on the severity of the disease. Nasal douching may be needed to remove the crusts. Endoscopic sinus surgery may be needed to treat secondary bacterial infection. Wegner’s granulomatosis: Definition: This condition is characterized by granulomatous inflammation involving the respiratory tract, airway, and kidneys. These lesions are characterized by vasculitis affecting small / medium sized blood vessels. Age and sex incidence: The age of presentation ranged from 15 – 70 years. It tends to affect both male and female sexes equally. Etiology: Unknown. It could represent some form of hypersensitivity reaction to an unknown stimulus. The stimulus could be a form of inhaled bacteria. This could explain the frequency with which the respiratory tract is involved. Immunology: 1. Immune complexes are deposited along the tunica intima of the blood vessels causing vasculitis. 2. Antibodies reacting with the cytoplasm of granulocytes and Monocytes have been demonstrated by van der Woude. 3. Two main forms of anti nuclear cytoplasmic antibodies have been demonstrated. Perinuclear (pANCA) and cytoplasmic (cANCA).

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Nose and sinuses are involved in more than 80% of cases. There may be intranasal destruction of bone and cartilage leading to collapse of nasal bridge. Diagnosis: 1. 2. 3. 4. 5. 6.

cANCA is positive in majority of these patients ESR is found to be elevated Serum angiotensin enzyme levels are increased Presence of vasculitis Granulomas are of epitheloid cell type Multinucleated giant cells have also been demonstrated

ACR criteria for diagnosis of wegner’s granulomatosis: Nasal oral inflammation: Development of painful / painless oral ulcers / purulent or bloody nasal discharge. Abnormal x-ray chest: Shows presence of nodules, infiltrates and cavities Urinary sediment: Microhematuria Biopsy: Granulomatous inflammation within the wall of an artery / arteriole

Treatment: The following drugs can be used in combination. 1. Steroids – Prednisolone 60 – 80mg/day 2. Cyclophosphamide – 2mg/kg/day 3. Azathioprine – can be used instead of Cyclophosphamide in doses of 200mg /day.

Non healing midline granuloma: Also known as Sinonasal lymphoma. Synonyms: 1. 2. 3. 4.

Lethal midline granuloma Stewart’s granuloma Polymorphic reticulosis T / NK cell lymphoma

This tumor is responsible for the classical destruction of the midface

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Classification: 1. Generalized lymphoma involving the Sinonasal tract 2. Lymphomas of waldayer’s ring extending to the nasopharynx 3. Peripheral – Sinonasal lymphoma the classic T cell lymphoma Age / Sex distribution: T/NK cell lymphoma may occur at any age from the 1st – 9th decade. Male preponderance has been documented. This disorder is associated with aggressive destruction of middle of face. This disease has classically been divided into three stages: 1. Prodromal stage: This stage could last for many years with the patient complaining of persistent nasal obstruction and rhinorrhoea. 2. Period of activity: Areas of necrosis develop on and around the nasal cavity associated with purulent nasal discharge, crusting and tissue loss. There is also progressive destruction of the nasal framework, palate, upper lip extending into the pharynx. Orbit and skull base also could be involved. 3. Terminal stage: This stage is characterized by gross mutilation of the face, exhaustion and eventual death. Systemic metastasis is also seen in this stage Histopathology: Nasal T cell lymphoma presents a diagnostic problem. Atypical cell infiltrates are found dispersed in necrotic areas. Immuno histochemistry using a panel of monoclonal antibodies against T cell differentiation antigen should be applied as 80% of peripheral T cell lymphomas show aberrant phenotypes. Histologically, the infiltrates are polymorphic and atypical cells. These atypical cells are atypical T lymphocytes. Thrombosis and necrosis are common findings. Granulomas and giant cells are not present in this condition. Treatment: These patients are initially treated with low dose irradiation. Now a complete course of radical radiotherapy of 55 Gy with wide field coverage including nose, sinuses and palate is administered. Chemotherapy is reserved for high grade tumors.

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