Ferrous Fumarate.pptx

Ferrous Fumarate Antimony gluconate

IUPAC name (E)-But-2-enedioate; iron(2+) Ferrous fumarate is the iron(II) salt of fumaric acid, occurring as a reddish-orange powder. It is used to supplement iron intake. Pure ferrous fumarate has an iron content of 32.87%, therefore one tablet of 100 mg iron fumarate will contain 32.86 mg of iron

Ferrous Fumarate (Iron II Sulphate) Properties Chemical formula

C4H2FeO4

Molar mass

169.90 g/mol

Appearance

reddish-brown powder

Odor

odorless

Density

2.435 g/cm (20 °C)

Melting point

280 °C (536 °F; 553 K)

Solubility in water

hardly soluble

Solubility in alcohol

Slightly soluble

3

Preparation The synthesis of iron(II) fumarate is based on the fumaric acid conversion into disodium fumarate by neutralization (1:2). Disodium fumarate, as intermediate mater, reacts with iron(II) sulfate (1:1), yielding iron(II) fumarate, brick-red precipitate with over 98 % purity. The reaction was performed in nitrogen atmosphere at 90 °C during 30 minutes providing an inert atmosphere required to prevent oxidation of ferrous ions to ferric.

USES • Pernicious anemia • Iron deficiency anemia • Iron deficiency • When patient can’t tolerate other iron preparation.

Antimony gluconate