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fischer b, and voynow j. (2000): neutrophil elastase induces muc5ac messenger rna expression by an oxidant-dependent mechanism. chest; 117(5 suppl. 1): 317-20s.

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floyd h., ni x, cornish am, zeng z., liu d. etal; (2000): a novel eosinopiiil specific number of the immunoglobulm superfamily. j. biol. chem. 275: 861-866.

'ibson p.g., simpson /./„, hankin r., powell h. and henry r.l. (2003): relationship between induced sputum eosinophils and the clinical pattern of childhood asthma. thorax; 58:116-121.



foster p.s., mould a. w., yang m. et al, (2001): elemental signals regulating eosinophil accumulation in the lung. immunol. rev, 179:173-181.



frew a.j. (2002): asthma biomarkers and drug trials. j. allergy clin. immunol; 109:210-213.



fujihara s., ward c, dransfield i., hay r., etal; (2002): inhibition of nuclear factor-kappab activation un-masks the ability of tnfalpha to induce human eosinopiiil apoptosis. eur. j. of immunology, 32(2): 457-466.



fujisawa t., kato k, nagase h., atsuta j. etal; (2000): chemokines induce eosmophil degranulation through ccr-3. j. allergy clin. immunol; 106:507-13.



fujitaka m., kawaguchi h., kato y., sakura is,, veda k. and abe y. (2001): significance of the eosinophil cationic protein/eosinophil count ratio in asthmatic patients: its relationship to disease severity. ann. allergy asthma. immunol; 86 (3): 323 -9.



gleich g,j. (2000): mechanisms of eosinophil associated inflammation. j. allergy clin. immunol., 105: 651-663. green r.h., brightllng c.e., mckenna &, hargadon b,, parker d. etal; (2002): asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. lancet. 30; 360 (9347): .1715-21. grootendorst d.c., vandenbos j.w., romeijn j.j., duiveman e.j. etal; (1999): induced sputum in adolescents with severe stable asthma. safty and the relationship of cell counts and eosinopiiil cationic protein to clinical severity. eur. respir.j., 13:647-653. hamelmann e. and gel/and e.w. (2001): ll-5-induced airway eosinophilia the key to asthma?. immunol. rev, 179:182-191.



gauvreau g.m., watson km., jordana m. and o'byrne p.m. (1996): effect of inhaled budesonide on allergen induced airway response and airway inflammation. am. j. respir. crit. care med. 154: 1267-1271.

amid q.a. and minshall e.m. (2000): molecular mechanisms in allergy and clinical immunology: molecular pathology of allergic disease: lower airway disease. j. allergy clin. immunol; 103:20-30. hamid q., tulic m.k., liu m.c. and moqbel r. (2003): inflammatory cells in asthma: mechanisms and implications fel therapy. j. allergy clin. immunol, 111: s5-17. haslett i., ward l, dransfield l, chilvers e.r. and rossi a.g. (1999): pharmacological manipulation of granulocyte apoptosis; potential therapeutic targets. trends pharmacol sci.; 20 (12): 503 -'



gauvreau g.m., watson r.m. and o'byrne p.m. (1999): kinetics of allergen induced airway eosinophilic cytokine production and airway inflammation. am. i. respir. crit. care med. 160: 640-647.

haslett c, (2000): asthma: cellular and humoral mechanisms. in crofton & douglas respiratory disease. 5 blackwell science ltd chapter 33: 907-921.



gauvreau g.m., wood l.i., sehmi r et al, (2000): the effects of inhaled budesonide on circulating eosinophil progenitors and expression of cytokines after allergen challenge in subjects with atopic asthma. am. j. respir. crit. care med,, 162:2139-2144.

hedge v.l and williams g.t. (2002): commitment to apoptolll induced by rumor necrosis factor-alpha is dependent on caspano activity. apoptosis; 7(2): 123-32.

gaidano r. (2003): messengers of cell death: apoptotic signaling in health and disease. haematologica, 88(2): 212-218.

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(gina) global initiative for asthma (2002): global strategy for asthma management and prevention (updated 2002).

edition, vol. 3;

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