Drug Study Ibuprofen
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Drug Name Name: Ibuprofen Brand Name: Children’s Motrin Classification: Non-steroidal antiinflammatory drugs
Dosage 100mg/5ml 5ml PRN, Oral
Indications o Mild to moderate pain o Fever o Juvenile arthritis
Mechanism of Action Unknown. Produces antiinflammatory, analgesic, and anti-pyretic effects, possibly by inhibiting prostaglandin synthesis.
Contraindications o Contraindicated in patients hypersensitive to drug and in those with angio-edema, syndrome of nasal polyps, or bronchospastic reaction to aspirin or other NSAIDs. o Contraindicated in pregnant women. o Use cautiously in patients GI disorders, history of peptic ulcer disease, hepatic or renal disease, cardiac decompensation, hypertension, preexisting asthma, or known intrinsic coagulation defects
Adverse Reaction CNS : headache, dizziness, nervousness, aseptic minigitis CV: peripheral edema, fluid retention, edema EENT: tinnitus GI: epigastric distress, nausea, occult blood loss, peptic ulceration, diarrhea, constipation, abdominal pain, bloating, GI fullness, dyspepsia, flatulence, heart burn, decreased appetite GU: acute renal failure, azotemia, cystitis, hematuria Hema to lo gic: prolonged bleeding time, anemia, neutroenia, pancytopenia, thrombocytopenia, aplastic anemia, leucopenia, agranulocytosis Meta bo lic: hypoglycemia, hyperkalemia Res pir ato ry : bronchospasm
Nursing Consideration o Check renal and hepatic function periodically in patients on long-term therapy. Stop drug if abnormalities occur and notify prescriber. o Because of their antipyretic and antiinflammatory actions, NSAIDs may mask signs and symptoms of infection o Blurred and diminished vision and changes in color vision have occurred o It may take 1 or 2 weeks before full antiinflammatory effects occur o Serious GI toxicity, including peptic ulcers and bleeding, in patient taking NSAIDs, despite lack of symptoms o If patient consumes three or more alcoholic drinks per day, use of ibuprofen may lead to stomach bleeding o Alert: don’t confuse Trendar with Trandate
Source: Nursing 2005 Drug Handbook 25th Edition
Dosage 100mg/5ml 5ml PRN, Oral
Indications o Mild to moderate pain o Fever o Juvenile arthritis
Mechanism of Action Unknown. Produces antiinflammatory, analgesic, and anti-pyretic effects, possibly by inhibiting prostaglandin synthesis.
Contraindications o Contraindicated in patients hypersensitive to drug and in those with angio-edema, syndrome of nasal polyps, or bronchospastic reaction to aspirin or other NSAIDs. o Contraindicated in pregnant women. o Use cautiously in patients GI disorders, history of peptic ulcer disease, hepatic or renal disease, cardiac decompensation, hypertension, preexisting asthma, or known intrinsic coagulation defects
Adverse Reaction CNS : headache, dizziness, nervousness, aseptic minigitis CV: peripheral edema, fluid retention, edema EENT: tinnitus GI: epigastric distress, nausea, occult blood loss, peptic ulceration, diarrhea, constipation, abdominal pain, bloating, GI fullness, dyspepsia, flatulence, heart burn, decreased appetite GU: acute renal failure, azotemia, cystitis, hematuria Hema to lo gic: prolonged bleeding time, anemia, neutroenia, pancytopenia, thrombocytopenia, aplastic anemia, leucopenia, agranulocytosis Meta bo lic: hypoglycemia, hyperkalemia Res pir ato ry : bronchospasm
Nursing Consideration o Check renal and hepatic function periodically in patients on long-term therapy. Stop drug if abnormalities occur and notify prescriber. o Because of their antipyretic and antiinflammatory actions, NSAIDs may mask signs and symptoms of infection o Blurred and diminished vision and changes in color vision have occurred o It may take 1 or 2 weeks before full antiinflammatory effects occur o Serious GI toxicity, including peptic ulcers and bleeding, in patient taking NSAIDs, despite lack of symptoms o If patient consumes three or more alcoholic drinks per day, use of ibuprofen may lead to stomach bleeding o Alert: don’t confuse Trendar with Trandate
Source: Nursing 2005 Drug Handbook 25th Edition
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