Diagnos Gynoncol
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Diagnostic Methods in Gynaecological Oncology Akinyinka O. Omigbodun Professor of Obstetrics & Gynaecology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Purpose Initial Assessment to Plan Patient’s Management Monitoring of Response to Therapy Assessing Prognosis
Methods History & Physical Examination Imaging Endoscopy Biochemical Markers
Methods (2) Immunological Markers Cellular/Tissue Diagnosis Genetic Markers & Gene Probes
Imaging
Ultrasonography
Transabdominal (TAUS)
Transvaginal (TVUS)
Cervix/Corpus/Ovaries/Trophoblast Cervix/Corpus/Ovaries/Trophoblast
Colour Doppler
Corpus/Ovaries/Trophoblast
Imaging
(2)
Plain X-rays
Generally of Limited Value Chest Abdomen Skeletal Survey
Imaging
(3)
Conventional Contrast Studies Intravenous Urography Hysterosalpingography Pelvic Angiography Lymphangiography
Imaging
(4)
Computerized Tomography Plain Contrast
Magnetic Resonance Imaging Plain Contrast (with Gadolinium)
Positron Emission
Imaging
(5)
Experimental Methods Optical Coherence Tomography
Images analysed quantitatively for intensity of backscattered light from the epithelia and for rates of signal decay over the depth of epithelia OCT images, which contain information about epithelial and stromal structure, can be clinically obtained. Image features of normal and abnormal cervical epithelium differ significantly.
OCT is a novel technique that can map subsurface tissue structure to a
Endoscopy Colposcopy Hysteroscopy Laparoscopy Cystoscopy Procto-sigmoidoscopy Culdoscopy
Biochemical Markers Electrolytes & Urea Creatinine/Uric Acid Calcium, Phosphorus Enzymes (e.g. LDH) Liver Function Tests Developmental (Embryonal) Proteins – hCG, αFP, CEA etc
Cellular / Tissue Diagnosis
Cytology
Conventional
Fine Needle Aspiration (FNAB)
Vulva/Vagina/Cervix/Corpus/Ovaries/Peritoneum /Urine Breast/Vulva/Ovaries
Histology
Regular Stains (Haematoxylin & Eosin) Special Stains (PAS, Silver Stains,
Genetic Markers/Gene Probes
Chromosomal Markers Specific Genes & Gene Products
BRCA 1; BRCA 2 Ras protein Her2-neu p53
THANK YOU
Purpose Initial Assessment to Plan Patient’s Management Monitoring of Response to Therapy Assessing Prognosis
Methods History & Physical Examination Imaging Endoscopy Biochemical Markers
Methods (2) Immunological Markers Cellular/Tissue Diagnosis Genetic Markers & Gene Probes
Imaging
Ultrasonography
Transabdominal (TAUS)
Transvaginal (TVUS)
Cervix/Corpus/Ovaries/Trophoblast Cervix/Corpus/Ovaries/Trophoblast
Colour Doppler
Corpus/Ovaries/Trophoblast
Imaging
(2)
Plain X-rays
Generally of Limited Value Chest Abdomen Skeletal Survey
Imaging
(3)
Conventional Contrast Studies Intravenous Urography Hysterosalpingography Pelvic Angiography Lymphangiography
Imaging
(4)
Computerized Tomography Plain Contrast
Magnetic Resonance Imaging Plain Contrast (with Gadolinium)
Positron Emission
Imaging
(5)
Experimental Methods Optical Coherence Tomography
Images analysed quantitatively for intensity of backscattered light from the epithelia and for rates of signal decay over the depth of epithelia OCT images, which contain information about epithelial and stromal structure, can be clinically obtained. Image features of normal and abnormal cervical epithelium differ significantly.
OCT is a novel technique that can map subsurface tissue structure to a
Endoscopy Colposcopy Hysteroscopy Laparoscopy Cystoscopy Procto-sigmoidoscopy Culdoscopy
Biochemical Markers Electrolytes & Urea Creatinine/Uric Acid Calcium, Phosphorus Enzymes (e.g. LDH) Liver Function Tests Developmental (Embryonal) Proteins – hCG, αFP, CEA etc
Cellular / Tissue Diagnosis
Cytology
Conventional
Fine Needle Aspiration (FNAB)
Vulva/Vagina/Cervix/Corpus/Ovaries/Peritoneum /Urine Breast/Vulva/Ovaries
Histology
Regular Stains (Haematoxylin & Eosin) Special Stains (PAS, Silver Stains,
Genetic Markers/Gene Probes
Chromosomal Markers Specific Genes & Gene Products
BRCA 1; BRCA 2 Ras protein Her2-neu p53
THANK YOU
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