Db For Unit2 Human Disease And Condition

Erin, One of the things I would talk about is the interaction with other drugs; some drugs have a higher likely hood for interaction than others. To date there are no drugs out that cure HIV infection or AIDS, the drugs do however keep the infection controlled, even to levels they are undetectable. For this reason it is vitally important to continue to take the antiretroviral drugs To make sure they know the importance to take all even over the counter drugs to all their doctors appointments to also let them know of any herb or alternative treatment they are or want to do Also to make sure you go over your medication list if they decide to add a drug to it, just to make sure it is compatible with the other medicine. To make sure they know that their medicines are prescribed for them and are geared toward their specific needs and should never be shared or given to anyone else for any reason.

Key teaching points Telling the patient about the medication letting them know for certain medicine there is a very high drug interaction to let them iknow the the signs and symptoms are in cause of an t Instruct patients that HIV medications, in particular PIs and NNRTIs, have a high potential for significant drug interactions. Tell patients to take all their medicines, including any herbal supplements and over-the-counter remedies, with them to all medical appointments. If they cannot take the actual bottles with them, they should make a list of current prescribed medications, supplements, and over-thecounter medications. Patients should have their primary care provider or pharmacist review any newly prescribed medications along with their current list of medicines. This is especially important if another physician prescribes a new medication. Patients should not "borrow" medications from friends or family. Assure patients that if they have a problem that needs medical treatment, their primary care provider will discuss it and choose the safest treatments for them. Tell patients that, if they are considering buying a new nutritional or herbal supplement or an over-the-counter product, they should consult their pharmacist or primary care provider about interactions with drugs on their current medication list. Not all drug interactions are cause for alarm. Some drug combinations are safe for certain people,

but less safe for others. Warn patients not to stop taking any medicines without the advice of their primary care provider.

Resources HIV In Site Database of Antiretroviral Drug Interactions: http://hivinsite.ucsf.edu/arvdb?page=ar00-02**

Food and Drug Administration 5600 Fishers Lane Rockville, MD 20857-0001 1-888-INFO-FDA (1-888-463-6332) www.fda.gov

1. Reverse transcriptase (RT) inhibitors interfere with the critical step during the HIV life cycle known as reverse transcription. During this step, RT, an HIV enzyme, converts HIV RNA to HIV DNA. There are two main types of RT inhibitors. •

Nucleoside/nucleotide RT inhibitors are faulty DNA building blocks. When these faulty pieces are incorporated into the HIV DNA (during the process when the HIV RNA is converted to HIV DNA), the DNA chain cannot be completed, thereby blocking HIV from replicating in a cell.

•

Non-nucleoside RT inhibitors bind to RT, interfering with its ability to convert the HIV RNA into HIV DNA.

2. Protease inhibitors interfere with the protease enzyme that HIV uses to produce infectious viral particles. 3. Entry and fusion inhibitors interfere with the virus' ability to fuse with the cellular membrane, thereby blocking entry into the host cell. 4. Integrase inhibitors block integrase, the enzyme HIV uses to integrate genetic material of the virus into its target host cell.

5. Multidrug combination products combine drugs from more than one class into a single product. To date there are no drugs out that cure HIV infection or AIDS, the drugs do however keep the infection controlled, even to levels they are undetectable. For this reason it is vitally important to continue to take the antiretroviral drugs