Clp Toxicology.docx

UNIVERSITI KUALA LUMPUR

SAMPLE

COURSE:

HCB 31403

UniKLMESTECH COURSE LEARNING PLAN To be shared with students.

SECTION A: COURSE DETAILS 1 2 3

Course Name Course Code Academic Staff Name(s)

4

Rationale for inclusion of Course in the Programme

5

Semester& Year Offered

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Student Learning Time (SLT)

7 8 9

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Credit Value Prerequisite Learning Outcomes

Transferable skills

TOXICOLOGY HCB 31403 NOOR ARNIWATI MAT DAUD DR. IZUDDIN FAHMY ABU NABILAH HANIM MOHD. SOBRI This course is aimed at providing students with essential knowledge on modern toxicology, including the principles, concepts and mechanisms of toxicities. This subject is essential particularly for medical laboratory and research laboratory based students, as well as allied health field in general, to strengthen their knowledge in medical and healthcare industry. Semester:1 Year:3 Face to Face (F2F) Lecture

Tutorial

Practical

Other

TOTAL

28

16

6

7

57

TOTAL

63

120

3 Human Pharmacology (HCB22103) Upon completion of this course students should be able to: 1. Distinguish the principles of toxicology of three different functional levels: cellular and molecular, physiological and environmental and ecological (C4). 2. Identify the actions of chemicals or substances that could lead to the development of cancer, mutations, congenital malformations and organs or systems specific effects (A4). 3. Collaborate with team members to predict toxicological effects and propose ideas to prevent toxicological incidents based on risk, environmental and alternative assessment (C5, A5). Skills Skills Development of the skills assessment Students are able to identify and analyze Assignment and Explanation and the toxicity effects of toxicants exposure exam interpreting towards human and environmental.

Teamwork & communication skills

11

Independent learning

Strategies    

Students are required to work in a team and to present their assigned work on toxicology related topics.

Teaching & learning Lecture Practical Online Discussion (VLE) PBL

     

Lecturer’s evaluationRubric for presentation skill and group work.

Assessment Mid Examination Written Test Final Examination Written Assignment Presentation Practical Report

COURSE LEARNING PLAN | Page 1 of 7

UNIVERSITI KUALA LUMPUR 12

Synopsis

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Mode of Delivery Assessment Methods

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SAMPLE

COURSE:

HCB 31403

This subject equips students with modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline. This subject also put focus on the field of toxicokinetics including exposure assessment, routes of exposure and distribution, biotransformation and excretion of toxicant. Lecture, Tutorial, Group Discussion Presentation Practical Report/Quizzes/Tests Mid Term Examination Final examination TOTAL

10% 20% 30% 40% 100%

COURSE LEARNING PLAN | Page 2 of 7

UNIVERSITI KUALA LUMPUR 15

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Mapping of Course to Programme Educational Objectives (PEOs) (✓) Mapping of Course to Programme Learning Outcomes (PLOs)

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References

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Additional information (if any)

SAMPLE PEO1

PEO2

✓

✓

COURSE: PEO3

PEO4

HCB 31403 PEO5

PLOs () CLOs 1 2 3

01

02

03

04

05

06

07

08

✓ ✓

Main 1. Sam Kacew, Byung-Mu Lee (2012). Lu’s Basic Toxicology: Fundamental, Targets Organs and Risk Assessment. CRC: 6th edition.

✓ Additional 1. A. Wallace Hayes, Claire L. Kruger (2014). Hayes' Principles and Methods of Toxicology. CRC. 6th edition. 2. Curtis D. Klaassen (2013). Casarett and Doull's Toxicology: The Basic Science of Poisons. McGraw-Hill Professional. 8th edition. 3. Kent R. Olson, Ilene B. Anderson, Neal L. Benowitz, Paul D. Blanc, Richard F. Clark, Thomas E. Kearney, Susan Y. Kim-Katz, Alan H. B. Wu (2011). Poisoning & Drug Overdose. McGraw-Hill Professional. 8th edition.

COURSE LEARNING PLAN | Page 3 of 7

UNIVERSITI KUALA LUMPUR

SAMPLE

COURSE:

HCB 31403

UniKLMESTECH COURSE LEARNING PLAN To be shared with students.

SECTION B: LEARNING SCHEDULE Topic 

16- 20/7/18 23/- 27/7/18

WEEK 2

WEEK 1

When

INTRODUCTION

1.0 PRINCIPLES OF TOXICOLOGY

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 Introduction to toxicology  Definition of toxicology  Purposes of toxicology

Delivery Method Virtual Ice breakers (Online Chat)

Relevant Assessments -

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Course briefing Lecture

 Mid Sem Exam  Final examination

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Lecture Tutorial

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Lecture Tutorial

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Lecture Tutorial

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Outcome(s): CLO 1

30/7- 3/8/18

WEEK 3

2.0 ABSORPTION, DISTRIBUTION & EXCRETION OF TOXICANTS    

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Mid Sem Exam Final Examination

Introduction Absorption Distribution Excretion

Outcome(s): CLO 1, 2

6- 10/8/18

WEEK 4

3.0 BIOTRANSFORMATION OF TOXICANTS    

General considerations Phase I (degradation) reactions Phase II (conjugation) reactions Bioactivation - Examples of bioactivation

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Mid Sem Exam Final Examination

Outcome(s): CLO 1, 2

13- 17/8/18

WEEK 5

4.0 TOXIC EFFECTS & MODIFYING FACTORS       

General considerations Spectrum of toxic effects Target organs Mechanisms of action Molecular targets & receptors Host & environmental factors Chemical interactions



Mid Sem Exam Final Examination

Outcome(s): CLO 1,2

COURSE LEARNING PLAN | Page 4 of 7

UNIVERSITI KUALA LUMPUR

SAMPLE

COURSE:  

20- 24/8/18

WEEK 6

5.0 CARCINOGENESIS     

Lecture Tutorial

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 

Lecture Practical

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Lecture

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Introduction Mode of action Categories of carcinogens Some human carcinogens / target organs Evaluation

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HCB 31403 Mid Sem Exam Final Examination

27-30/8/18

WEEK 7

Outcome(s): CLO 1, 2

Mid Term Examination (Chapter 1-5)

Mid Sem Break 3-7/9/2018

10-21/9/18

WEEK 8-9

6.0 TOXICANTS: MUTAGENESIS, DEVELOPMENTAL & LACTATION         

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Introduction Gene mutation Chromosomal effects DNA repair & recombination Teratogens (developmental toxicants) & effects Mode of action Teratogens of special interest Evaluation of teratogenic effects Lactation

Mid Sem Exam Final Examination

Outcome(s): CLO 1, 2

24/9/18-5/10/18

WEEK 10-11

7.0 TOXICOLOGY OF THE HUMAN BODY        

Toxicology of the immune system Respiratory system: Inhalation toxicology Toxicology of the liver Toxicology of the kidney Toxicology of the skin Toxicology of the eye Toxicology of the nervous system Reproductive & cardiovascular system

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Mid Sem Exam Final Examination

Outcome(s): CLO 1, 2

COURSE LEARNING PLAN | Page 5 of 7

UNIVERSITI KUALA LUMPUR

SAMPLE

COURSE:

8-12/10/18

WEEK 12

8.0 FOOD ADDITIVES & CONTAMINANTS     

HCB 31403

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Lecture Presentation

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Final Examination

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Online Lecture

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Final Examination

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Lecture Field trip

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Final Examination Written report

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Lecture

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Final Examination

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PBL

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Written report Final Examination

General principles of food additives & contaminants Major functional group of direct food additives Additives of toxicological concern Indirect additives & contaminants Contaminants

Outcome(s): CLO 2, 3

15-19/10/18

WEEK 13

9.0 TOXICITIES OF PESTICIDES & METALS  Pesticides  Metals  Over-the-counter preparations

Outcome(s): CLO 1, 2, 3

22-26/10/18

WEEK 14

10.0 ENVIRONMENTAL POLLUTANTS & OCCUPATIONAL TOXICOLOGY  Pollutants Air pollutants Water & soil pollutants  Occupational toxicology Exposure limits Occupational toxicants Monitoring

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Outcome(s): CLO 1, 2, 3

29/10/18-2/11/18

WEEK 15

11.0 CONVENTIONAL TOXICITY STUDIES    

Introduction Acute toxicity studies Short-term & Long-term toxicity studies Good laboratory practices

Outcome(s): CLO 2, 3

5-9/11/18

WEEK 16

12.0 TOXICOLOGIC EVALUATION: ASSESSMENT OF SAFETY / RISK  Introduction & major approaches  Acceptable daily intake (ADI) / safety assessment  International activities in toxicological evaluation

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Outcome(s): CLO 1, 2, 3 W8 W17

Practical 1: Ames test Field trip Pusat Kimia Negara, Kuala Lumpur

COURSE LEARNING PLAN | Page 6 of 7

UNIVERSITI KUALA LUMPUR W18

SAMPLE

COURSE:

HCB 31403

Revision for final examination

TOTAL Student Learning Time (hours)

120

= End of CLP copy for students =

COURSE LEARNING PLAN | Page 7 of 7