UNIVERSITI KUALA LUMPUR
SAMPLE
COURSE:
HCB 31403
UniKLMESTECH COURSE LEARNING PLAN To be shared with students.
SECTION A: COURSE DETAILS 1 2 3
Course Name Course Code Academic Staff Name(s)
4
Rationale for inclusion of Course in the Programme
5
Semester& Year Offered
6
Student Learning Time (SLT)
7 8 9
10
Credit Value Prerequisite Learning Outcomes
Transferable skills
TOXICOLOGY HCB 31403 NOOR ARNIWATI MAT DAUD DR. IZUDDIN FAHMY ABU NABILAH HANIM MOHD. SOBRI This course is aimed at providing students with essential knowledge on modern toxicology, including the principles, concepts and mechanisms of toxicities. This subject is essential particularly for medical laboratory and research laboratory based students, as well as allied health field in general, to strengthen their knowledge in medical and healthcare industry. Semester:1 Year:3 Face to Face (F2F) Lecture
Tutorial
Practical
Other
TOTAL
28
16
6
7
57
TOTAL
63
120
3 Human Pharmacology (HCB22103) Upon completion of this course students should be able to: 1. Distinguish the principles of toxicology of three different functional levels: cellular and molecular, physiological and environmental and ecological (C4). 2. Identify the actions of chemicals or substances that could lead to the development of cancer, mutations, congenital malformations and organs or systems specific effects (A4). 3. Collaborate with team members to predict toxicological effects and propose ideas to prevent toxicological incidents based on risk, environmental and alternative assessment (C5, A5). Skills Skills Development of the skills assessment Students are able to identify and analyze Assignment and Explanation and the toxicity effects of toxicants exposure exam interpreting towards human and environmental.
Teamwork & communication skills
11
Independent learning
Strategies
Students are required to work in a team and to present their assigned work on toxicology related topics.
Teaching & learning Lecture Practical Online Discussion (VLE) PBL
Lecturer’s evaluationRubric for presentation skill and group work.
Assessment Mid Examination Written Test Final Examination Written Assignment Presentation Practical Report
COURSE LEARNING PLAN | Page 1 of 7
UNIVERSITI KUALA LUMPUR 12
Synopsis
13
Mode of Delivery Assessment Methods
14
SAMPLE
COURSE:
HCB 31403
This subject equips students with modern toxicology, including the principles, concepts, mechanisms, and modes of thought that are the foundation of the discipline. This subject also put focus on the field of toxicokinetics including exposure assessment, routes of exposure and distribution, biotransformation and excretion of toxicant. Lecture, Tutorial, Group Discussion Presentation Practical Report/Quizzes/Tests Mid Term Examination Final examination TOTAL
10% 20% 30% 40% 100%
COURSE LEARNING PLAN | Page 2 of 7
UNIVERSITI KUALA LUMPUR 15
16
Mapping of Course to Programme Educational Objectives (PEOs) (✓) Mapping of Course to Programme Learning Outcomes (PLOs)
17
References
18
Additional information (if any)
SAMPLE PEO1
PEO2
✓
✓
COURSE: PEO3
PEO4
HCB 31403 PEO5
PLOs () CLOs 1 2 3
01
02
03
04
05
06
07
08
✓ ✓
Main 1. Sam Kacew, Byung-Mu Lee (2012). Lu’s Basic Toxicology: Fundamental, Targets Organs and Risk Assessment. CRC: 6th edition.
✓ Additional 1. A. Wallace Hayes, Claire L. Kruger (2014). Hayes' Principles and Methods of Toxicology. CRC. 6th edition. 2. Curtis D. Klaassen (2013). Casarett and Doull's Toxicology: The Basic Science of Poisons. McGraw-Hill Professional. 8th edition. 3. Kent R. Olson, Ilene B. Anderson, Neal L. Benowitz, Paul D. Blanc, Richard F. Clark, Thomas E. Kearney, Susan Y. Kim-Katz, Alan H. B. Wu (2011). Poisoning & Drug Overdose. McGraw-Hill Professional. 8th edition.
COURSE LEARNING PLAN | Page 3 of 7
UNIVERSITI KUALA LUMPUR
SAMPLE
COURSE:
HCB 31403
UniKLMESTECH COURSE LEARNING PLAN To be shared with students.
SECTION B: LEARNING SCHEDULE Topic
16- 20/7/18 23/- 27/7/18
WEEK 2
WEEK 1
When
INTRODUCTION
1.0 PRINCIPLES OF TOXICOLOGY
Introduction to toxicology Definition of toxicology Purposes of toxicology
Delivery Method Virtual Ice breakers (Online Chat)
Relevant Assessments -
Course briefing Lecture
Mid Sem Exam Final examination
Lecture Tutorial
Lecture Tutorial
Lecture Tutorial
Outcome(s): CLO 1
30/7- 3/8/18
WEEK 3
2.0 ABSORPTION, DISTRIBUTION & EXCRETION OF TOXICANTS
Mid Sem Exam Final Examination
Introduction Absorption Distribution Excretion
Outcome(s): CLO 1, 2
6- 10/8/18
WEEK 4
3.0 BIOTRANSFORMATION OF TOXICANTS
General considerations Phase I (degradation) reactions Phase II (conjugation) reactions Bioactivation - Examples of bioactivation
Mid Sem Exam Final Examination
Outcome(s): CLO 1, 2
13- 17/8/18
WEEK 5
4.0 TOXIC EFFECTS & MODIFYING FACTORS
General considerations Spectrum of toxic effects Target organs Mechanisms of action Molecular targets & receptors Host & environmental factors Chemical interactions
Mid Sem Exam Final Examination
Outcome(s): CLO 1,2
COURSE LEARNING PLAN | Page 4 of 7
UNIVERSITI KUALA LUMPUR
SAMPLE
COURSE:
20- 24/8/18
WEEK 6
5.0 CARCINOGENESIS
Lecture Tutorial
Lecture Practical
Lecture
Introduction Mode of action Categories of carcinogens Some human carcinogens / target organs Evaluation
HCB 31403 Mid Sem Exam Final Examination
27-30/8/18
WEEK 7
Outcome(s): CLO 1, 2
Mid Term Examination (Chapter 1-5)
Mid Sem Break 3-7/9/2018
10-21/9/18
WEEK 8-9
6.0 TOXICANTS: MUTAGENESIS, DEVELOPMENTAL & LACTATION
Introduction Gene mutation Chromosomal effects DNA repair & recombination Teratogens (developmental toxicants) & effects Mode of action Teratogens of special interest Evaluation of teratogenic effects Lactation
Mid Sem Exam Final Examination
Outcome(s): CLO 1, 2
24/9/18-5/10/18
WEEK 10-11
7.0 TOXICOLOGY OF THE HUMAN BODY
Toxicology of the immune system Respiratory system: Inhalation toxicology Toxicology of the liver Toxicology of the kidney Toxicology of the skin Toxicology of the eye Toxicology of the nervous system Reproductive & cardiovascular system
Mid Sem Exam Final Examination
Outcome(s): CLO 1, 2
COURSE LEARNING PLAN | Page 5 of 7
UNIVERSITI KUALA LUMPUR
SAMPLE
COURSE:
8-12/10/18
WEEK 12
8.0 FOOD ADDITIVES & CONTAMINANTS
HCB 31403
Lecture Presentation
Final Examination
Online Lecture
Final Examination
Lecture Field trip
Final Examination Written report
Lecture
Final Examination
PBL
Written report Final Examination
General principles of food additives & contaminants Major functional group of direct food additives Additives of toxicological concern Indirect additives & contaminants Contaminants
Outcome(s): CLO 2, 3
15-19/10/18
WEEK 13
9.0 TOXICITIES OF PESTICIDES & METALS Pesticides Metals Over-the-counter preparations
Outcome(s): CLO 1, 2, 3
22-26/10/18
WEEK 14
10.0 ENVIRONMENTAL POLLUTANTS & OCCUPATIONAL TOXICOLOGY Pollutants Air pollutants Water & soil pollutants Occupational toxicology Exposure limits Occupational toxicants Monitoring
Outcome(s): CLO 1, 2, 3
29/10/18-2/11/18
WEEK 15
11.0 CONVENTIONAL TOXICITY STUDIES
Introduction Acute toxicity studies Short-term & Long-term toxicity studies Good laboratory practices
Outcome(s): CLO 2, 3
5-9/11/18
WEEK 16
12.0 TOXICOLOGIC EVALUATION: ASSESSMENT OF SAFETY / RISK Introduction & major approaches Acceptable daily intake (ADI) / safety assessment International activities in toxicological evaluation
Outcome(s): CLO 1, 2, 3 W8 W17
Practical 1: Ames test Field trip Pusat Kimia Negara, Kuala Lumpur
COURSE LEARNING PLAN | Page 6 of 7
UNIVERSITI KUALA LUMPUR W18
SAMPLE
COURSE:
HCB 31403
Revision for final examination
TOTAL Student Learning Time (hours)
120
= End of CLP copy for students =
COURSE LEARNING PLAN | Page 7 of 7