Chapter 10 Outline

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Abnormal Psychology 30

3/18/09 Chapter 10 - Substance-Related and Impulse-Control Disorders

Substance-Related Disorders: Overview



The Nature of Substance-Related Disorders 

Use and abuse of psychoactive substances 

Broad class of drugs that alters mood/behavior ingested to get intoxicated/high



Wide-ranging physiological, psychological, and behavioral effects



Associated with impairment and significant costs 

Costs Billions of $/year



Kills 500,000 people/year



Implicated in street crime, homelessness, and gangs

Some Important Terms and Distinctions





Substance use vs. Substance intoxication 

Substance use -



Substance intoxication –

Tolerance vs. withdrawal 

Tolerance - needing increasing amounts to achieve intoxication/diminished effect with continued use



Withdrawal - characteristic withdrawal syndrome or relieving/avoiding withdrawal symptoms by taking the

same (or closely related) substance Substance Abuse DSM-IV Checklist



A 12-month period of maladaptive pattern of substance use 

Recurrent use in situations in which it 

.



.



.



Based on extent of SDI -



Criteria for substance dependence isn’t met

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Substance Dependence DSM-IV Checklist



Addiction is a 12-month period marked by 

.



.



.



.



.



Use despite knowledge of a persistent physical or psychological problem caused or exacerbated by the substance

Five Main Categories of Substances



Depressants -



Stimulants -



Opiates -



Hallucinogens -



Other drugs -

The Depressants: Alcohol Use Disorders



Psychological and Physiological Effects of Alcohol 

Central Nervous system depressant



Influences several neurotransmitter systems

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Effects of Chronic Alcohol Use



Liver disease, pancreatitis, CVD, brain damage



Withdrawal may include tremors, nausea, vomiting, anxiety, insomnia, agitation, and withdrawal delirium (DTs) 



Delirium tremens can produce hallucinations and body tremors

Associated brain conditions 

Dementia - neurotoxicity



Wernicke’s disease - thiamine deficiency



Fetal alcohol syndrome (FAS) in babies

Alcohol: Facts and Statistics



In the United States 

Most adults consider themselves light drinkers or abstainers



Over 50% of people 12 years and older report current use



Alcohol use is highest among Caucasian Americans



Males use and abuse alcohol more so than females



Violence is associated with alcohol 



Does not cause aggression, rather it reduces fear and increases impulsivity

Statistics on Abuse and Dependence 

23% report binge drinking (5 or more in one occasion), many people fluctuate in their use



15 million Americans are alcohol dependent



20% with alcohol problems experience spontaneous recovery

Sedative, Hypnotic, or Anxiolytic Substance Use Disorders: Overview





The Nature of Drugs in This Class 

Sedatives -



Hypnotic -



Anxiolytic -

Effects Are Similar to Large Doses of Alcohol 

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Relaxes muscles (Rohypnol or “roofies”)

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Combining such drugs with alcohol is synergistic

.

Depressant Drugs DSM-IV Checklist



Includes maladaptive behavioral changes 

nappropriate sexual or aggressive behavior



Variable moods



Impaired judgment



Impaired social or occupational functioning

Stimulants: Overview



Nature of Stimulants 

Most widely consumed drug in the U.S. 

Used for asthma, nasal congestion, and weight loss, narcolepsy, and ADHD



Such drugs increase alertness and increase energy



Examples include amphetamines (speed and ecstasy), cocaine, nicotine, and caffeine

Stimulants: Amphetamine Use Disorders



Effects of Amphetamines 

Produce elation, vigor, reduce fatigue



Such effects are followed by extreme fatigue and depression “crash”



Amphetamines stimulate CNS by



.



.



Excess can cause hallucinations/delusions



Withdrawal similar to depression

Amphetamine Intoxication DSM Checklist



Euphoria or affective blunting



Psychological Symptoms

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Sociability and Interpersonal sensitivity; anxiety, tension, or anger; impaired judgment, social, or occupational

functioning



Physiological symptoms 

Changes in HR and BP; perspiration or chills, nausea or vomiting; weight loss; muscular weakness; respiratory

depression; chest pain; seizures or coma Stimulants: Cocaine Use Disorders





Effects of Cocaine 

.



Short lived sensations of elation, vigor, reduce fatigue



Highly addictive, but addiction develops slowly

Most Cycle Through Patterns of Tolerance and Withdrawal

Stimulants: Nicotine Use Disorders





Effects of Nicotine

.



Small doses results in sensations of relaxation, wellness, pleasure



High doses can blur vision, cause confusion, cunvulsions, death



Long term use can cause high BP, Heart disease, COPD, and cancer



Highly addictive

Smoking has complex relationship to negative affect 

Appears to help improve mood in short-term



Related to depression, anxiety, and anger 

Depression occurs more in those with nicotine dependence



Relapse rates equal those seen with alcohol and heroin



About 30% of Americans are smokers

Stimulants: Caffeine Use Disorders



Effects of Caffeine – The “Gentle” Stimulant 

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Small doses elevate mood and reduce fatigue



Large doses produces jitteriness and insomnia



Regular use can result in tolerance and dependence



Withdrawal includes headaches, drowsiness, and general unpleasant mood

3/18/09

Used by over 90% of Americans

Opiods: Overview



The Nature of Opiates and Opiods 

Opiate -



Opiods -



Often referred to as analgesics (relieves pain)



Includes Methadone, Heroin, opium, codeine, and morphine



Effects of Opiods 

.



Low doses induce euphoria, drowsiness, and slowed breathing



High doses can result in death if respiration is completely depressed.



Opiates are analgesics (i.e., substances that help relieve pain such as morphine).

Opiods: Facts and Statistics



Withdrawal symptoms can be lasting and severe (Symptoms for 1-3 days) 



excessive yawning, nausea and vomiting, chills, muscle aches, diarrhea, and insomnia

Mortality rates are high for opiod addicts 

High risk for HIV infection



28% die prematurely due to homicide, suicide, and accidents 

Maduramente

33% of these result from overdose

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Hallucinogens: Overview



Nature of Hallucinogens 

Change the way the user perceives the world



May produce 



Delusions, paranoia, hallucinations, altered sensory perception

Examples include marijuana, LSD, psilocybin, and mescaline

Hallucinogens: Marijuana



Marijuana (from cannabis sativa) 

Reactions to marijuana include mood swings, heightened sensory experiences, paranoia, hallucinations,

dizziness, and impairment of memory, concentration, amotivational syndrome, self-esteem, and interpersonal and occupational relationships. 

Withdrawal and dependence are uncommon



Evidence suggest tolerance in heavy users, reverse tolerance in regular users

Hallucinogens: LSD



LSD is most common form of hallucinogenic drug



Produced synthetically from the ergot fungus 

This fungus was known in the Middle Ages to lead to ergotism - constricted blood flow to the arms or legs,

eventually resulting in gangrene and loss of limbs 

Another type of illness resulted in convulsions, delirium, and hallucinations

Hallucinogens: Other Hallucinogens



Other Hallucinogens 

Psilocybin- found in certain species of mushrooms



Lysergic acid amide- found in the seeds of the morning glory plant



Dimethyltryptamine- found in the bark of the Virola tree which grows in South and Central America



Mescaline- found in the peyote cactus plant

LSD and Other Hallucinogens: Facts



LSD and Other Hallucinogens 

Tolerance is rapid and withdrawal symptoms are uncommon 

Maduramente

Repeated use causes loss of effectiveness, complete abstinence for a week returns sensitivity

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Can produce psychotic delusions and hallucinations (e.g., people jumping out of windows because they believed

they could fly). Hallucinogens: Marijuana and LSD



Structure of these drugs mimic natural neurtransmitters 

Marijuana contains cannabinoids, most common is tetrahydrocannabinol (THC) 

 

.

LSD and psilocybin is similar to serotonin

Mescaline resembles norepinephrine

Hallucinogens DSM Checklist



Hallucinogen intoxication are similar to those for marijuana



Include perceptual changes 

ntensification of perceptions



Depersonalization



Hallucinations



Papillary dilation



Rapid heart beat



Sweating



Blurred vision.

Other Drugs of Abuse: Inhalants





Nature of Inhalants 

.



Breathed directly into lungs and rapidly absorbed into bloodstream



.



Tolerance and prolonged symptoms of withdrawal are common

Examples 

Aerosole sprays, paint thinner, gasoline, markers, and nitrous oxide (whippets), etc.

Other Drugs of Abuse: Anabolic Steroids



Nature of Anabolic-Androgenic Steroids 

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Used medicinally (asthma, anemia, breast cancer) or to increase body mass



Users may engage in cycling or stacking



.



Can result in long-term mood disturbances and physical problems

3/18/09

Other Drugs of Abuse: Designer Drugs



Drugs produced by pharmaceutical companies for specific diseases/disorders



All produce tolerance and withdrawal



Ecstasy 



MDEA or “Eve” and BDMPEA or “Nexus” 



.

Ketamine (street name “K,” “Special K,” or “Cat Valium) 



.

.

GHB or “Liquid Ecstasy” 

CNS depressant marketed in health food stores in the 1980s as muscle growth stimulants



.



.

Causes of Substance-Related Disorders: Family and Genetic Influences



Results of Family, Twin, and Adoption Studies 

Substance abuse has a genetic component



Much of the focus has been on alcoholism

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Genetic differences in alcohol metabolism

Multiple genes are involved in substance abuse

Neurobiological Influences



Results of Neurobiological Research 

Drugs affect the pleasure or reward centers in the brain



Positive reinforcement –



Negative reinforcement –

Psychological Dimensions





Role of Positive and Negative Reinforcement 

Positive reinforcement –



Negative reinforcement –

The self-medication and the tension reduction hypotheses 





.

Opponent-Process Theory 

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.

Role of Expectancy Effects 

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3/18/09

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Cravings

Social and Cultural Dimensions







Exposure to Drugs is a Prerequisite for Use of Drugs 

Media, family, peers



Parents and the family appear critical

Societal Views About Drug Abuse 

Psychological view –



Biological view –

The Role of Cultural Factors 

Influence the manifestation of substance abuse 

College subculture normalizes episodes of binge drinking



Korean culture expects binge drinking in certain occasions



Native Americans use substances for religious ceremonies

Treatment of Substance-Related Disorders



Motivation to work on the problem is essential



Generally, prognosis is not positive



Balancing Treatment Goals 

Complete abstinence –



Controlled use –

Biological Treatment of Substance-Related Disorders



Agonist Substitution 

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Abnormal Psychology 30  Antagonistic Treatment 

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3/18/09

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Aversive Treatment 

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Other kinds include antidepressants and sedatives



Efficacy of Biological Treatment 

Generally ineffective when used alone

Psychosocial Treatment of Substance-Related Disorders



Inpatient vs. Outpatient Care 



Community Support Programs 



Little difference in effectiveness

Alcoholics Anonymous (AA) and related groups (e.g., NA) seem helpful and are strongly encouraged

Comprehensive Treatment and Prevention Programs 

Individual and group therapy



Aversion therapy and convert sensitization



Contingency management



Community reinforcement



Relapse prevention



Preventative efforts via education

DSM-IV-TR Impulse-Control Disorders



Each is Characterized by 

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Intermittent Explosive Disorder



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Facts 

Rare condition



Leads to injury and/or destruction of property



Few controlled treatment studies, but CBT interventions and approaches modeled after drug treatment programs

seem to be most effective Kleptomania



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Facts 

Seems rare, but it is not well studied



Highly comorbid with mood disorders



Also co-occurs with substance-related problems

Pyromania



.



Facts 

Diagnosed in less than 4% of arsonists



Little etiological and treatment research

Pathological Gambling



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Facts 

Affect 3-5% adult Americans



Treatment is similar to that for substance dependence

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Abnormal Psychology 30

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Trichotillomania



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Facts 

Observed in 1-5% of college students, mostly female



Clomipramine and CBT have been shown to be helpful

Summary of Substance-Related Disorders



.







Psychosocial Factors Interact with Biological Influences

Treatment of Substance Dependence 

Largely unsuccessful



Highly motivated persons do best



Important to use comprehensive approach

DSM-IV-TR Substance Related Disorders 

Cover Four Classes 



Depressants, stimulants, opiates, and hallucinogens

Diagnoses include dependence, abuse, intoxication, or withdrawal

An Integrative Model of Substance-Related Disorders



Exposure or Access to a Drug 





Is a necessary, but not sufficient

Drug Use/Abuse Depends on many complex reasons 

Social and cultural expectations



The pleasurable consequences



Presence of major stressors



Genetic Influences



The premise of equifinality

Consider psychological, genetic, social, and learning factors

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