Cell Injury & Death

Clinical vignette r old female develops severe belt-like abdominal ter having a gallbladder surgery. Cullen and Grey signs visible on abdominal wall. Amylase was very h rum calcium too low. After 2 days of treatment the p hypovolemic shock

-TYPE OF NECROSIS -MECHANISM -THE CLEAR YEWLOWISH AREAS REPRESENT… -DIAGNOSIS…

CELL INJURY & DEATH: PART II R. HUGO MARTÍNEZ LOZANO, M.D. August 29, 2006.

LEARNING OBJECTIVES: K & U REVERSIBLE & IRREVERSIBLE  NECROSIS - MORPHOLOGY - TYPES - EXAMPLES  APOPTOSIS - MORPHOLOGY - TYPES - EXAMPLES  INTRACEL. ACCUMULATIONS - IDEM. Ref: pp. 19-32, 34-40 % lecture’s info 

EXAMPLES OF CELL INJURY & NECROSIS   

ISCHEMIC/HYPOXIC ISCHEMIC-REPERFUSION CHEMICAL

Clinical vignette: o male is admitted in the ER c/o severe abdominal pa being evaluated he is taken to surgery, where you a see this image:

mpare with this slide of the patient’s small bowel ich structures are preserved, which have changed?

k for normal cellular shapes and nuclear appearance

REPERFUSION DAMAGE

TYPES OF NECROSIS     

COAGULATION LIQUEFACTION GANGRENOUS CASEOUS FAT (ENZYMATIC)

COAGULATION NECROSIS

IDEM

ABSCESS: TOPOGRAPHY?

LUNG & LYMPH NODE: TB

FAT (ENZYMATIC) NECROSIS

2 PATHS: -INT. -EXT.

ULTRASTRUCTURE: APOPTOTIC BODY

TYPES OF ACCUMULATIONS    

LIPIDS PROTEINS (HYALINE INCLUDED) GLYCOGEN PIGMENTS

FATTY LIVER