Cell Injury & Death

A 28 y-o man, after a weekend of heavy rum drinking developed severe abdominal pain and a Cullen (+) sign. At the PE we found hemorrhagic ascitis. He died. Autopsy feature shown:

-MOST IMPORTANT LAB FEATURES? -TYPE OF NECROSIS -MECHANISM -THE CLEAR YELLOWISH AREAS REPRESENT… -DIAGNOSIS…

CELL INJURY & DEATH: PART II R. HUGO MARTÍNEZ LOZANO, M.D. July-21-2009.

LEARNING OBJECTIVES: K & U REVERSIBLE & IRREVERSIBLE  NECROSIS: - CAUSES - MORPHOLOGY - TYPES - EXAMPLES  APOPTOSIS: - CONCEPT - MORPHOLOGY - TYPES - EXAMPLES  INTRACEL. ACCUMULATIONS: IDEM.  MEDICAL SIGNIFICANCE!!! Ref: pp. 19-32, 34-40 & lecture’s information 

EXAMPLES OF CELL INJURY & NECROSIS   

ISCHEMIC/HYPOXIC ISCHEMIC-REPERFUSION CHEMICAL

DIAGNOSIS? ETIOLOGY?

k for normal cellular shapes and nuclear appearance

mpare with this slide of the patient’s small bowel ich structures are preserved, which have changed?

REPERFUSION DAMAGE

TYPES OF NECROSIS     

COAGULATION LIQUEFACTION GANGRENOUS CASEOUS FAT (ENZYMATIC)

COAGULATION NECROSIS

IDEM

ABSCESS: TOPOGRAPHY?

LUNG & LYMPH NODE: TB

APOPTOSIS

2 PATHS: -EXT. (Death R.) (TNFR1, FAS) -INT. (Mitoch.) (Citochrome C)

ULTRASTRUCTURE: APOPTOTIC BODY

TYPES OF ACCUMULATIONS    

LIPIDS PROTEINS (HYALINE INCLUDED) GLYCOGEN PIGMENTS

FATTY LIVER

Kaiser-Fleisher ring

-MOST IMPORTANT LAB FEATURES? -TYPE OF NECROSIS -MECHANISM -THE CLEAR YELLOWISH AREAS REPRESENT… -DIAGNOSIS…

“Los hombres que no pudieron ser santos, se esforzaron por ser médicos”. Albert Camus