Cell Cycle(brief Summary)
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The cell cycle Brief summary
Regulation of the Cell Cycle Regulatory signals Check-points Cyclins – CDKs – CKI(INK4 proteins + Cip/Kip family )
Cell-Cycle Checkpoints
Progression regulatory of cell cyclye • • • • •
1.Cyclin binding 2.CDk phosphorylations state 3.Cdk inhibitors 4.Controlled proteolysis 5.Sub cellular localization
Oncogene - tumorsuppressor gene G0
PDGFR
EGFR Cyclin D CDK4,6
G1a M p16, p15 p21 p27
p53
Cyclin A,B CDK2
G1c
pRB
G2
E2F
p21 p27
G1d
S Cyclin A CDK2
Cyclin E CDK2
G1b
Cyclin E CDK2
Regulation of the Cell Cycle Regulatory signals Check-points Cyclins – CDKs – CKI(INK4 proteins + Cip/Kip family )
Cell-Cycle Checkpoints
Progression regulatory of cell cyclye • • • • •
1.Cyclin binding 2.CDk phosphorylations state 3.Cdk inhibitors 4.Controlled proteolysis 5.Sub cellular localization
Oncogene - tumorsuppressor gene G0
PDGFR
EGFR Cyclin D CDK4,6
G1a M p16, p15 p21 p27
p53
Cyclin A,B CDK2
G1c
pRB
G2
E2F
p21 p27
G1d
S Cyclin A CDK2
Cyclin E CDK2
G1b
Cyclin E CDK2
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