Ceftriaxone.pdf
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DRUG:
CEFTRIAXONE
ALERTS & RESTRICTIONS:
Antimicrobial Restriction- Restricted
PRESENTATION:
Vial:
ACTION & INDICATION:
Third generation cephalosporin
1g
Used to treat infections caused by susceptible organisms Active against both gram negative and gram positive organisms with the exception of Pseudomonas species, enterococci
DOSE:
50mg/kg/dose 24 hourly Meningitis: 100mg/kg loading dose, then 80mg/kg every 24 hours
PREPARATION:
Use solution prepared in Pharmacy if available. Intravenous: Diluent: Water for Injections Add 9.6mL diluent to 1g vial = 100mg/mL Intramuscular: Diluent: Lignocaine 1% injection Add 3.6mL or 2.4mL =250mg/mL ≈350mg/mL
ADMINISTRATION: Intramuscular: As per NCCU policy. Very painful, avoid if possible Intravenous: Infuse over 30 minutes via syringe pump, or slow IV push.
ADVERSE EFFECTS:
Do not use with calcium containing solutions as precipitate may form Displaces bilirubin from serum albumin. Use with caution in neonates with hyperbilirubinaemia. Diarrhoea, eosinophilia, neutropenia Rash, colitis
COMMENTS:
Discard reconstituted solution immediately after use Ceftriaxone is incompatible with calcium and should not be reconstituted, admixed or infuse simultaneously with any calciumcontaining solution via a Y-site.
REFERENCES:
Pediatric and Neonatal Dosage Handbook 21st Edition 2014 Australian Medicines Handbook Children’s Dosing Companion 2016
Ceftriaxone V2.0
Last Reviewed: September 2016
For Review: September 2018
Do not keep printed versions of guidelines. Access current version from the WNHS website. Page 1 of 1
CEFTRIAXONE
ALERTS & RESTRICTIONS:
Antimicrobial Restriction- Restricted
PRESENTATION:
Vial:
ACTION & INDICATION:
Third generation cephalosporin
1g
Used to treat infections caused by susceptible organisms Active against both gram negative and gram positive organisms with the exception of Pseudomonas species, enterococci
DOSE:
50mg/kg/dose 24 hourly Meningitis: 100mg/kg loading dose, then 80mg/kg every 24 hours
PREPARATION:
Use solution prepared in Pharmacy if available. Intravenous: Diluent: Water for Injections Add 9.6mL diluent to 1g vial = 100mg/mL Intramuscular: Diluent: Lignocaine 1% injection Add 3.6mL or 2.4mL =250mg/mL ≈350mg/mL
ADMINISTRATION: Intramuscular: As per NCCU policy. Very painful, avoid if possible Intravenous: Infuse over 30 minutes via syringe pump, or slow IV push.
ADVERSE EFFECTS:
Do not use with calcium containing solutions as precipitate may form Displaces bilirubin from serum albumin. Use with caution in neonates with hyperbilirubinaemia. Diarrhoea, eosinophilia, neutropenia Rash, colitis
COMMENTS:
Discard reconstituted solution immediately after use Ceftriaxone is incompatible with calcium and should not be reconstituted, admixed or infuse simultaneously with any calciumcontaining solution via a Y-site.
REFERENCES:
Pediatric and Neonatal Dosage Handbook 21st Edition 2014 Australian Medicines Handbook Children’s Dosing Companion 2016
Ceftriaxone V2.0
Last Reviewed: September 2016
For Review: September 2018
Do not keep printed versions of guidelines. Access current version from the WNHS website. Page 1 of 1
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