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National National Center Center for for Genetic Genetic Engineering Engineering and and Biotechnology Biotechnology (BIOTEC) (BIOTEC) Thailand Thailand
BIOTEC BIOTEC Background Background and and Mission Mission • Established in 1983 as a Research Centre • Part of the National Science and Technology Development Agency (NSTDA) • Operates outside the normal framework of civil service and state enterprises • Main objectives – induce dynamics of research and development through the application of biotechnology (research programs, research funding and research management) – establish research laboratories with universities and government agencies – human resource development, technical service, public awareness and international cooperation
NSTDA NSTDA Organization Organization
(established (establishedby byaaspecial speciallaw lawin in1991) 1991)
NSTDA Board chaired by Minister of Science and Technology
NSTDA BIOTEC
MTEC TMC
NECTECิ NANOTEC
NSTDA : National Science and Technology Development Agency BIOTEC : National Center for Genetic Engineering and Biotechnology MTEC : National Metal and Materials Technology Center NECTEC : National Electronics and Computer Technology Center NANOTEC: National Nanotechnology Center TMC : Technology Management Center
BIOTEC BIOTEC Research Research Units Units Chiang Mai University
Chiang Mai
Cassava/Starch R&D Kasetsart University Khon Kaen
Rice Gene Discovery Kasetsart University
Shrimp Molecular Biology Mahidol University
Marine Biotech Chulalongkorn University Bangkok
Biochemical Engineering KMUTT
Medical Biotechnology Mahidol University
Central Research Unit Science Park
Phuket Hat Yai
Peat Swamp & Tropical Rain Forest (Royal Forestry Department)
Distribution Distribution of of R&D R&D Funding* Funding* Rice Biotechnology Plant Biotechnology Shrimp Biotechnology Animal Biotechnology Bioprocess, Bioindustry, Novel Products, Food Innovation Medical Biotechnology Environmental Biotechnology and Sustainable Development Biotechnology for Rural Development
* R&D budget distribution for FY 2005 (millions USD)
International International Publications Publications 180
165
160
145
140
140
127 109
120 100 78
80
75
61 60
45
40 20
47
25 7
9
7
0 1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
(Total 1040)
Intramural
Extramural
Research Research and and Development Development Excellence Excellence and and Relevance Relevance Rice Biotechnology
Crop Improvement and Seed Technology
Cassava Biotechnology
Biodiversity/Biopesticies
International Rice
Genome Sequencing Project (IRGSP)
Chr. 9
Marker Marker Assisted Assisted Selection Selection KDML 105 + Submergence + Bacterial Leaf Blight + brown planthopper + salt = super jasmine rice KDML105+QTLsub+Xa21
KDML105
KDML105+QTLsub+Xa21
Waxy WaxyRice Rice
Low-amylose Low-amyloseRice Rice
High-amylose High-amyloseRice Rice
Breeding BreedingRice RiceVariety Varietyfor forIndustrial IndustrialApplication Application
Cassava Cassava Molecular Molecular Biotechnology Biotechnology Consortium Consortium • To understand the details of starch metabolism in cassava • To produce novel cassava cultivars with high yielding, tailor-made starch [specific granule size] ………. high value cassava
Genome -wide analysis Genome-wide analysis of of cassava cassava transcriptome transcriptome Generation of cassava EST database Gene identification by Suppression Subtractive Hybridization Gene expression profile during storage root formation by cDNA-AFLP
Crop Crop Improvement Improvement Papaya Papaya Ringspot Ringspot Virus Virus Resistance Resistance
Susceptible Susceptible papaya papaya Resistant Resistant Papaya Papaya
Crop Crop Improvement Improvement Tomato Tomato Yellow Yellow Leaf-Curl Leaf-Curl Virus Virus Resistance Resistance
ER1-19 ER1-19 (Delayed (DelayedSymptoms) Symptoms)
Susceptible SusceptibleLine Line
ER1-16 ER1-16(Resistant) (Resistant)
Biotechnology Biotechnology for for Rural Rural Development Development
Rubber RubberPlantation Plantation
Etlingera Etlingeraelatior elatior
Germplasm Germplasm Collection Collection and and Breeding Breeding for for New New Varieties Varieties
Entomopathogenic Entomopathogenic Fungi Fungi
Paecilomyces Paecilomyces lilacinus lilacinus ((Meloidogyne Meloidogynespp.) spp.)
Germplasm Germplasm Evaluation Evaluation
Rice: yield, disease (blast, bacterial leaf blight, rice-ragged stunt virus), nutrition Cassava: starch content, cyanide content, yield Corn: 25 characters (size, seed color, yield, disease, sweetness, tenderness) Sugarcane: yield, brix, number of stalks, stalk per stool, fiber Pepper: anthracnose, virus, fruitfly, capsaicin, early maturity, single harvest, indeterminate Tomato: color, sugar content, firmness and lycopene
International International Collaboration Collaboration -Regional Regional Training Training Center Center in in Biotechnology Biotechnology • HRD Program for Neighboring Countries and the Pacific Islands • Training Workshops and Short Courses • Short and medium term training at BIOTEC laboratories (3 - 12 months) • Operating since 2001 targeting Cambodia, Laos, Myanmar and Vietnam. Pacific Islands were added in 2005 with special funding from the New Zealand • 2001 - 2005: 46 scholarships were awarded. At least six former trainees are now studying in Germany, Canada and AIT in Thailand.
International International Collaboration Collaboration -Regional Regional Training Training Center Center in in Biotechnology Biotechnology •
Plant Genetic Diversity Analysis and Marker-Assisted Breeding in collaboration with CGIAR (2005)
•
Regional Training Workshop on GMO Testing in collaboration with FAO (2003) •
Regional Workshops on Molecular Breeding in Rice for Mekong Region in collaboration with Kasetsart University and the Rockefeller Foundation (2004 – 2005)
International International Collaboration Collaboration -Bilateral Bilateral Collaboration Collaboration MOU MOU--Tropical TropicalBiology Biologyand and Biotechnology Biotechnology Student Studentexchange exchangeprogram program Thermophilic Thermophilicenzymes enzymes
USFDA USFDABetter Better Process ProcessControl Control School SchoolTraining Training Course Course
Drug DrugDiscovery Discovery
Cosmetic Cosmeticresearch research
National National Center Center for for Genetic Genetic Engineering Engineering and and Biotechnology Biotechnology (BIOTEC) (BIOTEC) Thailand Thailand – Responsible for research and development through the application of biotechnology – Achieves this through research funding and management and the establishment of research laboratories with universities and government agencies
– Promotes capacity building through resource development, technical services, public awareness and international cooperation
National National Center Center for for Genetic Genetic Engineering Engineering and and Biotechnology Biotechnology (BIOTEC) (BIOTEC) Thailand Thailand
BIOTEC BIOTEC Background Background and and Mission Mission • Established in 1983 as a Research Centre • Part of the National Science and Technology Development Agency (NSTDA) • Operates outside the normal framework of civil service and state enterprises • Main objectives – induce dynamics of research and development through the application of biotechnology (research programs, research funding and research management) – establish research laboratories with universities and government agencies – human resource development, technical service, public awareness and international cooperation
NSTDA NSTDA Organization Organization
(established (establishedby byaaspecial speciallaw lawin in1991) 1991)
NSTDA Board chaired by Minister of Science and Technology
NSTDA BIOTEC
MTEC TMC
NECTECิ NANOTEC
NSTDA : National Science and Technology Development Agency BIOTEC : National Center for Genetic Engineering and Biotechnology MTEC : National Metal and Materials Technology Center NECTEC : National Electronics and Computer Technology Center NANOTEC: National Nanotechnology Center TMC : Technology Management Center
BIOTEC BIOTEC Research Research Units Units Chiang Mai University
Chiang Mai
Cassava/Starch R&D Kasetsart University Khon Kaen
Rice Gene Discovery Kasetsart University
Shrimp Molecular Biology Mahidol University
Marine Biotech Chulalongkorn University Bangkok
Biochemical Engineering KMUTT
Medical Biotechnology Mahidol University
Central Research Unit Science Park
Phuket Hat Yai
Peat Swamp & Tropical Rain Forest (Royal Forestry Department)
Distribution Distribution of of R&D R&D Funding* Funding* Rice Biotechnology Plant Biotechnology Shrimp Biotechnology Animal Biotechnology Bioprocess, Bioindustry, Novel Products, Food Innovation Medical Biotechnology Environmental Biotechnology and Sustainable Development Biotechnology for Rural Development
* R&D budget distribution for FY 2005 (millions USD)
International International Publications Publications 180
165
160
145
140
140
127 109
120 100 78
80
75
61 60
45
40 20
47
25 7
9
7
0 1993
1994
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
(Total 1040)
Intramural
Extramural
Research Research and and Development Development Excellence Excellence and and Relevance Relevance Rice Biotechnology
Crop Improvement and Seed Technology
Cassava Biotechnology
Biodiversity/Biopesticies
International Rice
Genome Sequencing Project (IRGSP)
Chr. 9
Marker Marker Assisted Assisted Selection Selection KDML 105 + Submergence + Bacterial Leaf Blight + brown planthopper + salt = super jasmine rice KDML105+QTLsub+Xa21
KDML105
KDML105+QTLsub+Xa21
Waxy WaxyRice Rice
Low-amylose Low-amyloseRice Rice
High-amylose High-amyloseRice Rice
Breeding BreedingRice RiceVariety Varietyfor forIndustrial IndustrialApplication Application
Cassava Cassava Molecular Molecular Biotechnology Biotechnology Consortium Consortium • To understand the details of starch metabolism in cassava • To produce novel cassava cultivars with high yielding, tailor-made starch [specific granule size] ………. high value cassava
Genome -wide analysis Genome-wide analysis of of cassava cassava transcriptome transcriptome Generation of cassava EST database Gene identification by Suppression Subtractive Hybridization Gene expression profile during storage root formation by cDNA-AFLP
Crop Crop Improvement Improvement Papaya Papaya Ringspot Ringspot Virus Virus Resistance Resistance
Susceptible Susceptible papaya papaya Resistant Resistant Papaya Papaya
Crop Crop Improvement Improvement Tomato Tomato Yellow Yellow Leaf-Curl Leaf-Curl Virus Virus Resistance Resistance
ER1-19 ER1-19 (Delayed (DelayedSymptoms) Symptoms)
Susceptible SusceptibleLine Line
ER1-16 ER1-16(Resistant) (Resistant)
Biotechnology Biotechnology for for Rural Rural Development Development
Rubber RubberPlantation Plantation
Etlingera Etlingeraelatior elatior
Germplasm Germplasm Collection Collection and and Breeding Breeding for for New New Varieties Varieties
Entomopathogenic Entomopathogenic Fungi Fungi
Paecilomyces Paecilomyces lilacinus lilacinus ((Meloidogyne Meloidogynespp.) spp.)
Germplasm Germplasm Evaluation Evaluation
Rice: yield, disease (blast, bacterial leaf blight, rice-ragged stunt virus), nutrition Cassava: starch content, cyanide content, yield Corn: 25 characters (size, seed color, yield, disease, sweetness, tenderness) Sugarcane: yield, brix, number of stalks, stalk per stool, fiber Pepper: anthracnose, virus, fruitfly, capsaicin, early maturity, single harvest, indeterminate Tomato: color, sugar content, firmness and lycopene
International International Collaboration Collaboration -Regional Regional Training Training Center Center in in Biotechnology Biotechnology • HRD Program for Neighboring Countries and the Pacific Islands • Training Workshops and Short Courses • Short and medium term training at BIOTEC laboratories (3 - 12 months) • Operating since 2001 targeting Cambodia, Laos, Myanmar and Vietnam. Pacific Islands were added in 2005 with special funding from the New Zealand • 2001 - 2005: 46 scholarships were awarded. At least six former trainees are now studying in Germany, Canada and AIT in Thailand.
International International Collaboration Collaboration -Regional Regional Training Training Center Center in in Biotechnology Biotechnology •
Plant Genetic Diversity Analysis and Marker-Assisted Breeding in collaboration with CGIAR (2005)
•
Regional Training Workshop on GMO Testing in collaboration with FAO (2003) •
Regional Workshops on Molecular Breeding in Rice for Mekong Region in collaboration with Kasetsart University and the Rockefeller Foundation (2004 – 2005)
International International Collaboration Collaboration -Bilateral Bilateral Collaboration Collaboration MOU MOU--Tropical TropicalBiology Biologyand and Biotechnology Biotechnology Student Studentexchange exchangeprogram program Thermophilic Thermophilicenzymes enzymes
USFDA USFDABetter Better Process ProcessControl Control School SchoolTraining Training Course Course
Drug DrugDiscovery Discovery
Cosmetic Cosmeticresearch research
National National Center Center for for Genetic Genetic Engineering Engineering and and Biotechnology Biotechnology (BIOTEC) (BIOTEC) Thailand Thailand – Responsible for research and development through the application of biotechnology – Achieves this through research funding and management and the establishment of research laboratories with universities and government agencies
– Promotes capacity building through resource development, technical services, public awareness and international cooperation
National National Center Center for for Genetic Genetic Engineering Engineering and and Biotechnology Biotechnology (BIOTEC) (BIOTEC) Thailand Thailand
