B.seshu Babu

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B.SESHU BABU C/O Uttam Namdeo Bankar, Survey no - 13, Flat no - 186, Opp.Akasavani, Bankar colony, Hadapsar, Pune – 411028, Maharastra state. Phone : 9850669675,9923414353. Email :- [email protected], [email protected].

OBJECTIVE

To prove my self in responsible and challenging position that gives me scope to apply my knowledge and skill and be a leader of the team that dynamically works towards success and growth of the organization.  

SKILLS

 

Mammalian cell culture and Virus production : Process development, optimization, standardization from 10 L scale to 200 L scale. Yeast and Bacterial Fermentation : Process development, optimization, standardization from 10 L scale to 200 L scale. Preparation and maintenance of MWCB, WCB and seed cultures of mammalian cell line, Virus, yeast and Bacterial cultures. Process validation, Equipment validation , Cleaning validation of Fermentors, Bioreactors and other peripheral equipments.

EXPERIENCE :

2000 - PRESENT

2005 – Till date

JOB PROFILE

ACHIEVEMENT

Serum Institute Of India Ltd.( SIIL ) Pune. I had accomplished 10 years experience in fermentation field with successful out puts. During this period I was offered to work in different projects - Hepatitis-B Vaccine Manufacturing and Rabies Vaccine Manufacturing. Asst. Manager. Rabies Vaccine Development. SIIL. • At present working on Rabies Vaccine Development using bioreactors ( S.S and Disposable Bioreactor ). • The central theme of development is, Rabies virus production using MRC-5 cells ( Human Diploid Cells ) as a substrate. • The beauty of the technology is, microcarriers and bioreactor are used for cell growth and virus production, where microcarriers provides surface for growing MRC-5 cells and bioreactor ensures fast cell growth and high virus yield compared to other traditional viral production methods.  Batch planning and manpower handling.  Chemicals and raw material arrangement.  Trouble shooting of bioreactors and other equipments.  Planning and handling of production process in GMP aspects.  Process control and taking corrective action to resolve the deviations in the process.  Process and equipment optimization, standardization and validation.  Preparation of process and equipment related documents ( SOPs, BMR, log books, Deviation reports, change controls, IQ, OQ, PQ ).

Rabies Virus Production using Bioreactor developed successfully and brought up to 200 L scale from initial 10 L scale. Large scale production process established using 200 L Disposable Bioreactor.

2000 – 2005

Executive Officer Hepatitis – B Vaccine Production. SIIL • Worked as a fermentation team leader in Hepatitis – B vaccine production at 200 L scale. • Managed to implement process development methods in production in order to increase the yield. • Developed economic strategies and easy handling methods to resolve the practical difficulties in large scale production. • Prepared process and equipment validation documents, change controls , deviation reports and log books etc. in view of WHO audit.

ACHIEVEMENT

Optimized and standardized fermentation process of recombinant yeast Hansenula Polymorpha at 200 L scale of Hepatitis – B vaccine production. Actively participated in WHO audit.

1999 - 2000

Research Associate Sat’s Biotech, Hyderabad • Worked on media and process development of high cell density cultivation of Lactobacillus Sporogenous Bacteria.

ACHIEVEMENT

Developed a unique fermentation medium, which can give high cell density and fast spores formation of Lactobacillus Sporogenous Bacteria.

1997 - 1999

Supervisor Shantha Biotechnics Pvt Ltd, Hyderabad • Worked as a shift in-charge in Hepatitis – B vaccine production (World first recombinant vaccine using yeast Pichia Pastoris ) at 100 L scale. • Handled entire process ( upstream and Down stream ) of Hepatitis – B vaccine production from seed culture preparation to final bulk filtration.

COMPUTER COMPETENCY

Well acquaintance with SAP system. Well conversant with windows environment in advance version, word perfect, Grapher, Software, Internet usage for data bank search, patents, etc.

PERSONAL DETAILS NAME FATHER’S NAME DATE OF BIRTH GENDER MARITAL STATUS PERMANENT ADDRESS EDUCATIONAL QUALIFICATION SUBJECTS COVERED IN M. Sc

Seshu Babu. Burrala Subbarao. Burrala 28 / 06 /1974 Male Married B.Seshu Babu , S/O B.Subba Rao , Bommuluru post, Gudivada mandal, Krishna district, Pin: 521 330, Andhrapadesh, Phone: (08674-242004). M.Sc Biotechnology (1996) from Nagarjuna University, Guntur. B.Sc (CBZ) from ANR College Gudivada, Nagarjuna University. Microbiology, Immunotechnology, Fermentation technology, Biochemistry, Molecular biology, Genetic engineering, Tissue culture, Cell biology, and Enzyme technology.

( B.SESHU BABU )

DATE

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