Brand Name: Diflucan Generic Name: Fluconazole Drug Classification: Antibiotics (antifungal)

Brand name: Diflucan Generic name: Fluconazole Drug Classification: Antibiotics (Antifungal) Indication: Adult: Oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlifethreatening Candida infections (cystitis, esophaglitis); treatment of hepatosplenic candidiasis and other Candida infections in person unable to tolerate amphotericin B; treatment of cryptococcal infections; secondary prophylaxis in allogeneic bone marrow transplant recipients. Mechanism of action: Interferes with cytochrome P-450 activity, decreasing ergosterol synthesis (principal sterol in fungal cell membrane) and inhibiting cell membrane formation. Dose: Adult Candidiasis, disseminated candidiasis & other invasive candidal infection 400 mg on the 1 st day followed by 200 mg daily. Vaginal candidiasis150 mg as single oral dose. Oropharyngealcandidiasis 50 mg once daily for 7-14 days. If necessary, continue treatment for longer periods in patients w/ severely compromised immune function. Candidal infection of mucosa 50 mg daily for 14- 30 days, may be increased up to 100 mg daily. Children mucosal candidiasis 3 mg/kg. Systemic candidiasis 6-12 mg/kg daily. Prevention of candidiasis based on risk o developing fungal infections 50-400 mg once daily. Deep endemic mycoses200-400 mg daily for up to 2 yr. Cryptococcal meningitis & cryptococcal infections at other sites 400 mg on the 1st day followed by 200- 400 once daily for atleast 6-8 wk. Prevention of relapse of cryptococcal meningitis in patients w/ AIDS 200 mg daily after a full course of primary therapy. Atrophic oral candidiasis associated with dentures 50 mg once daily for 14 days concurrently w/ local antiseptic measures to the denture. Dermal infection including tinea

pedis, corporis, cruris & candida infections 150 mg once wkly or 50 mg once daily for 2-4 wk (tinea pedis: up to 6 wk). Tinea vesicolor 50 mg once daily for 2-4 wk. Contraindication: Known hypersensitivity to fluconazole or other azoles; concomitant administration with terfenadine. Special Precaution: Pregnancy, lactation Adverse Reactions: CNS: headache GI: hepatotoxicity, abdominal discomfort, diarrhea, nausea, vomiting Derm: exfoliative skin disorder including Stevens - Johnson syndrome. Drug Interaction: Warfarin, oral sulfonylureas, phenytoin, rifampicin, cyclosporin, theophylline, terfenadine, zidovudine, OC. Form: Capsule- 50mg, 150mg, 200mg; vial- 2mg/mL Pregnancy Risk Category: C Nursing Responsibilities:  Assess infected area and monitor CSF cultures before and periodically during therapy.  Monitor BUN and serum creatinine before and periodically during therapy.  Monitor liver function tests before and periodically during therapy.