Brand Name: Aspirin Generic Name: Acetyl Salicylic Acid Drug Classification:
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Brand name: Aspirin Generic name: Acetyl Salicylic Acid Drug Classification: Analgesics & Antipyretics Indication: Relief of headache, toothache, muscular and joint pains, dysmenorrheal, and to reduce fever. Mechanism of action: In your cells there are hormone messengers called prostaglandins. These send out pain and inflamation signals to the body. The prostaglandins are synthesized by an enzyme known as prostaglandin H2 synthase (PGHS) which has a "tunnel" running through the middle of it where prostaglandins are synthesized. Aspirin and salicylic acid attach to the inside of this tunnel where they act like a valve or gate that inhibits prostaglandin prescursors from accessing the active site of the enzyme. And if prostaglandins aren't produced, reduced pain and swelling will occur. Dose: Adult 1-2 tab; Children ½-1 tab 4 hourly as needed Contraindication: Children and teenagers with chicken pox or flu symptoms. Haemophilia. Infant <1 yr. Special Precaution: Patients prone to dyspepsia or known lesions of gastric mucosa and allergy. Impaired renal and hepatic function esp. with dehydrated children.
Adverse Effects: EENT: hearing loss, tinnitus, GI: GI bleeding, dyspepsia, epigastric distress, heartburn, nausea, abdominal pain, anorexia, hypertoxicity, vomiting Hemat: anemia, hemolysis, increased bleeding time Misc: allergic reactions including anaphylaxis and laryngeal edema, noncardiogenic pulmonary edema. Form: Tablet- 325 mg Pregnancy Risk Category: C; D if full dose aspirin use in 3rd trimester Nursing Responsibilities: Pain: Assess pain and limitation of movement; note type, location and intensity before and at the peak after administration. Fever: Assess fever and note associated signs I diaphoresis, tachycardia, malaise, chills). Monitor hematocrit periodically in prolonged high- dose therapy to assess for GI blood. Aspirin prolongs bleeding time for 4-7 days and in large doses may cause prolonged prothrombin time. Toxicity and overdose: Monitor patient for the onset of tinnitus, headache, hyperventilation, agitation, mental confusion, lethargy, diarrhea, and sweating.
Adverse Effects: EENT: hearing loss, tinnitus, GI: GI bleeding, dyspepsia, epigastric distress, heartburn, nausea, abdominal pain, anorexia, hypertoxicity, vomiting Hemat: anemia, hemolysis, increased bleeding time Misc: allergic reactions including anaphylaxis and laryngeal edema, noncardiogenic pulmonary edema. Form: Tablet- 325 mg Pregnancy Risk Category: C; D if full dose aspirin use in 3rd trimester Nursing Responsibilities: Pain: Assess pain and limitation of movement; note type, location and intensity before and at the peak after administration. Fever: Assess fever and note associated signs I diaphoresis, tachycardia, malaise, chills). Monitor hematocrit periodically in prolonged high- dose therapy to assess for GI blood. Aspirin prolongs bleeding time for 4-7 days and in large doses may cause prolonged prothrombin time. Toxicity and overdose: Monitor patient for the onset of tinnitus, headache, hyperventilation, agitation, mental confusion, lethargy, diarrhea, and sweating.
