Bimm 110 Section 10 Pset

BIMM 110 Molecular Basis of Human Disease TA: George Chen [email protected] OH: Tu 12:30-1:30 Sierra Summit or by appointment See Announcements Section: W 4:00-4:50 Center 203

Problem Set 10 Announcements: • FRIDAY SECTION: Friday June 5th, 4-6pm, Cog Sci Building (CSB) 5 • Final Exam: Monday June 8th, 3-6pm, Mandeville Auditorium • Review session with Professor Zhang: Saturday June 6th, 10am-12pm, Center 105 • This problem set covers lecture 17 and 18. • GOOD LUCK ON THE FINAL! 1. Describe how insulin works to lower blood glucose levels. In what ways may a body become resistant to insulin?

2. How have twin studies contributed to our understanding of the onset of Type I diabetes? Type II diabetes?

3. Risk for type II diabetes is largely determined by family history, age, _____________, and ____________________. 4. What did the Diabetes Control and Complications Trial (DCCT) indicate about the treatment of diabetes?

5. What are the molecular mechanisms by which GLP-1 drugs work?

6. Embryonic stem cells are obtained from the _________________________________ of a developing embryo. One example of adult stem cells are blood stem cells, which can be obtained from ____________________________. The process of blood cell differentiation is known as ___________________________. 7. Describe the potential use of embryonic stem cells for tissue repair. What issues must be considered?

8. True/False. The efficiency of inducible pluripotent stem cell production is unaffected by the loss of Myc expression. 9. Why are cancer stem cells resistant to traditional anti-cancer therapy? What is believed to be the result of this inability to kill off cancer stem cells?

10. Explain how scientists demonstrated the existence of blood stem cells.