Ascorbic Acid As A Thiolprive Ability To Induce I...[physiol Chem Phys. 1981] - Pubmed Result
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1: Physiol Chem Phys. 1981;13(4):325-33.
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Ascorbic acid as a thiolprive: ability to induce immunity against some cancers in mice. Knock FE, Gascoyne PR, Sylvester R, Wibel R. Immunological studies are reported showing that ascorbic acid, like selected sulfhydryl inhibitors, can induce immunity against some cancers in mice. Accompanying this immunizing action are changes in the surface structure of the cancer cells, as revealed by scanning electron microscopy. Electron spin resonance measurements show that the ascorbate anion free radical is readily produced in oxygenated cancer tissue and that this radical can react with sulfhydryl groups which are free radical scavengers. It is proposed that ascorbate acts as an effective thiolprive in oxygenated cancer tissues. This action is thought to lead to the observed changes in the cancer cell surface structure and to the concomitant immunological response. Publication Types: Comparative Study PMID: 6276908 [PubMed - indexed for MEDLINE] Display
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About Entrez Text Version Entrez PubMed Overview Help | FAQ Tutorials New/Noteworthy E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher Clinical Queries Special Queries LinkOut My NCBI Related Resources Order Documents NLM Mobile NLM Catalog NLM Gateway TOXNET Consumer Health Clinical Alerts ClinicalTrials.gov PubMed Central
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1: Physiol Chem Phys. 1981;13(4):325-33.
Send to Related Articles, Links
Ascorbic acid as a thiolprive: ability to induce immunity against some cancers in mice. Knock FE, Gascoyne PR, Sylvester R, Wibel R. Immunological studies are reported showing that ascorbic acid, like selected sulfhydryl inhibitors, can induce immunity against some cancers in mice. Accompanying this immunizing action are changes in the surface structure of the cancer cells, as revealed by scanning electron microscopy. Electron spin resonance measurements show that the ascorbate anion free radical is readily produced in oxygenated cancer tissue and that this radical can react with sulfhydryl groups which are free radical scavengers. It is proposed that ascorbate acts as an effective thiolprive in oxygenated cancer tissues. This action is thought to lead to the observed changes in the cancer cell surface structure and to the concomitant immunological response. Publication Types: Comparative Study PMID: 6276908 [PubMed - indexed for MEDLINE] Display
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