Amyotrophic Lateral Sclerosis
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Amyotrophic Lateral Sclerosis (ALS) • Degenerative disease of the CNS with involvement of both UMN and LMN • S/S Asymmetric weakness, ↑ reflex, fasciculation and muscle atrophy A→ bulbar involvement → Aspiration → mod RSI B→ respiratory failure C→ D→ Sux C/I, ↑ sensitivity to NDMR, M→ abnormal glucose and Ca metabolism, with thyroid dysfunction • Do Regional technique better • If GA: Mod RSI, ICU post-op
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