Aki

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Acute Kidney Injury Dr Rob Lewis Consultant in Intensive Care Ipswich Hospital

Introduction         

Normal functions of the Kidney Classical description of renal failure Acute Kidney Injury/Failure RIFLE Classification Incidence within Intensive Care Sepsis and AKI Mortality Treatment and Prevention Myths

Normal Kidney Function      

Fluid Balance Electrolyte Control Acid-base balance Metabolism and Excretion Hormone production Erythropoietin production

Classical approach 

Three classic causes 

Pre-renal failure 



Hypovolaemia, hypotension

Intrinsic renal failure Acute Tubular Necrosis,  Toxic injury 



Post-renal failure 

Renal outflow tract obstruction

Acute Kidney Injury 

 





Spectrum of disorders from reduced function to established failure Multi-factorial causes Associated with reduced Glomerular filtration and Oliguria, which may initially be appropriate. Involves sub lethal damage causing depolarization and loss of normal function Cell death through necrosis and

RIFLE classification GFR/Creatinine criteria

Urine Output criteria

Risk

Increase in creatinine x1.5 Or GFR decrease >25%

UO < .5ml/kg/hr for 6hrs

Injury

Increase in creatinine x 2 Or GFR decrease >50%

UO < .5ml/kg/hr for 12hrs

Failure

Increase in creatinine x 3 Or GFR decrease >75%

Loss

UO < .3ml/kg/hr for 24 hrs or Anuria for 12hrs

Persistent ARF = complete loss of renal function > 4 weeks

ESRD

End Stage Renal Disease > 3 months

RIFLE classification 

Represents 

3 Classes of increasing severity



2 Outcome groups



Shift from supposed pathologies i.e. ATN



Clinical spectrum with associated morbidity and mortality

Incidence In ICU    



67% of Critical care patients have AKI 12% class R 27% class I 28% class F However more than half of patients with class R will progress to either class I or F

Hoste et al Crit Care 2006

Incidence in ICU 







Approximately 5% of patients in general intensive cares will require RRT Equates to 200-300 per million population Similar numbers to severe sepsis or ARDS 10-20% of surviving patients require ongoing RRT beyond hospital

Sepsis and AKI 



Sepsis accounts for nearly 50% of all causes of AKI Combination of Factors Immunological  Toxic  Inflammatory 



Effect renal microvasculature and Tubular cells

AKI and Mortality      

AKI is an independent risk factor for death Patients don’t just die with AKI they die because of AKI RIFLE class F have a mortality of 57% RIFLE class I 45% RIFLE class R 21 % Compared to 8.4% of patients without AKI

Ostermann M, Chang RW: CCM 2007

AKI and Mortality 

As already mentioned rising RIFLE class associated with increasing mortality



Despite advances in critical care medicine and technology, patients who are treated with RRT still have a mortality of 50-60%

Treatment        

Prevent it in the First Place!! Treat / Remove the Cause Restore adequate circulating Volume Restore adequate blood pressure Restore adequate flow Control fluid intake Wait, Patience is a virtue! Renal replacement therapy

Prevention   

Early intervention and resuscitation Little evidence available Mainly in Contrast induced AKI Best evidence for volume loading with isotonic fluid  Sodium Bicarbonate may be better than Normal Saline  N-Acetylcysteine shown to reduce risk 

Myths 

Frusemide    



Theoretically may reduce tubular injury Due to shutting down Na/K/Cl ATPase Reduces oxygen demand May help with fluid balance

But    

No clinical evidence Accumulates in Oliguria Nephrotoxic and Ototoxic May actually increase mortality and or need for RRT

Myths 

Dopamine Low dose Dopamine (2-3mcg/kg/min), known as “renal dose”  No effect on mortality or need for Renal replacement therapy 

Myths 

Vasopressors and AKI Although Noradrenaline causes vasoconstriction with renal vasculature  No evidence of worsening AKI  But should be used after adequate volume resuscitation 

Myths 

Mannitol Currently no evidence of protective effect  Causes an osmotic diuresis with may benefit fluid balance 

Questions?

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