Adrenergic Drugs

Muscarinic Agonists and Antagonists

Classificatio n Adrenergic agonists

Drug Name Isoproterenol

MOA

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β1 selective agonist

Increases heart rate and cardiac output quickly, treat shock

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Dobutamine

Adrenergic agonists

α1 selective agonist (potent vasoconstrictors Phenylephrine; with longer time Methoxamine course of action than NE, little CNS penetration)

Adrenergic Antagonists

Clonidine

Propanolol

side effects

Non-selective βagonist

Adrenergic agonists

Adrenergic agonists

Therapeutic Effect

α2 selective agonist, central autoinhibitory effect

Non-selective βantagonist

Treat hypotensive states, restore/maintain BP during spinal (blank) anaesthesia, mydriatic, and nasal congestion Antihypertensive

Antihypertensive, treat angina

Depression (due to ↓NE) Incre. bradycardia, peripheral claudication, asthma, CNS (fatigue, sleep disturbance, depression) metabolic (blunting hypoglycemia response, delaying

Adverse Effects

Adrenergic Agonists Drug

Acti on

Receptor

Pharmacologic Use

Epinephrine Direct alpha and beta catecholamine

rapid relief of allergic rxn, bronchodilator, prolong action of local anaesthetics,

Norepineph Direct alpha and beta rine catecholamines

increase PVR in shock, hypotension

ephedrine

mixed

alpha and beta

isoproteren beta selective direct ol catecholamine dobutamine

dopamine albuterol

direct mixed

narcolepsy, obesity emergency heart block, emergency bradycardia, or pacemaker in torsades de pointes

beta 1 selective catecholamine

acute cardiac failure, CHF, post op or post MI

beta 1 selective, D1 receptor renal, alpha 1 selective (high)

different types of shock, profound hypotension, CHF, incr urine output (dopa vs beta effect)

direct beta 2 selective

bronchodilator used in asthma

phenylephri direct alpha 1 selective ne

mydriatic used to faciliate retina exam, cariothoracic surgery to increase PVR with minimal/controllable cardiac effects, nasal decongestant

clonidine

antihypertensive agent, withdrawl syndromes, analgesic

direct alpha 2 selective