CUSHING DISEASE; PANDUAN KLINIS DIAGNOSIS & TATA LAKSANA Oleh;
Eva Niamuzisilawati,dr.SpPD
DIVISI ENDOKRINOLOGI METABOLIK DIABETES FK UNS/RSUD Dr Moewardi 2018
Gambaran HPA Axis pada individu sehat dan Cushing disesase
Normal HPA Physiology
Physical Features
Treatment ◼ ◼ ◼
Stop exogenous glucocorticoid Surgery Medication to control hypercortisolism ◼
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Mitotane, ketoconazole, metyrapone, aminoglutethimide, trilostane, and etomidate Often fail
Radiation if surgery not possible Must have stress-dose steroids pre-, intra-, post-op