52421_dusting Powder.pptx

Dusting Powder (PULVIS) By: Andi Nafisah T.A.M, S.Farm.,M.Sc

Dusting powder for external use These are dry, free flowing preparations consisting of one or a mixture of finely powdered substances and intended for external application.

The advantages of dusting powders as pharmaceutical products are • They are easy to apply. • They are pleasant to use. • They absorb skin moisture, which leads to reduced friction between skin surfaces, • Discourages bacterial growth and has a cooling effect.

The disadvantages of dusting powders as pharmaceutical products are • They may block pores, causing irritation, or if applied to parietal surfaces, granulomas, fibrosis or adhesions. • There is a possibility of contamination: Starch, although an excellent dusting powder, is organic and can support microbial growth. Talc, despite being an inert compound, can be contaminated with microorganisms and must therefore always be sterilised prior to incorporation into a dusting powder. • Light fluffy powders may be inhaled by infants, causing breathing difficulties. • They are not suitable for application to broken skin.

Common ingredients included in dusting powders and their properties

Properties

Ingredients

Absorbent

Bentonite BP Kaolin BP Starch BP Talc BP

Dispersing and lubricating for ease of application

Starch BP Talc BP

Adhesives that help the powder to stick to the skin

Aluminium Stearate BP Magnesium Stearate BP Zinc Stearate BP

Increase 'lightness and fluffiness'

Prepared Chalk BP Zinc Stearate BP

White, with good covering properties

Talc BP Zinc Oxide BP

Clostridium tetani, Clostridium welchii and Bacillus anthracis be heavily contaminated to

Some commonly used ingredients such as talc, kaolin and other natural mineral substances

Which can cause tetanus and gangrene.

Therefore, such ingredients must have been sterilise before use.

Gangren: mengacu pada kematian jaringan tubuh karena kurangnya aliran darah atau infeksi bakteri. Kondisi ini terjadi setelah seseorang mengalami luka, infeksi, atau masalah kesehatan kronis yang memengaruhi sirkulasi darah.

Tetanus yang juga dikenal dengan lockjaw, merupakan penyakit yang disebakan oleh tetanospasmin, yaitu sejenis neurotoksin yang diproduksi oleh Clostridium tetani yang menginfeksi sistem urat saraf dan otot sehingga saraf dan otot menjadi kaku (rigid).

Common active ingredients included in dusting powders and their properties

Properties Antibakteri/ antifungal Astringents Cooling antipruritic ingredients

Ingredients Sulphur BP Aluminium Chloride BP Tannic Acid BP Menthol BP Thymol BP Camphor BP

The label of a pharmaceutical product has many functions:

To indicate clearly the contents of the container To indicate clearly to patients how and when the medicinal product should be taken or used To indicate clearly to patients how the product should be stored and for how long To indicate clearly to patients any warnings or cautions of which they need to be made aware.

Permanent reminder!!!

Some techniques of powder dust preparation

•Trituration •Incorporate I •Incorporate II