2. Drug Study
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IX.
DRUG STUDY
NAME
CLASSIFICATION
ACTION
Generic Name: Metronidazole Brand Name: Flagyl
Antiprotozoals or Antimicrobials
Direct -acting trichomonacide and amebicide that works inside and outside the intestines. It’s thought to enter the cells of microorganisms that contain nitroreductase, forming unstable compounds that bind to DNA and inhibit synthesis, causing cell death.
Generic name: Cefuroxime Brand Name: Zinacef
Cephalosporins
Inhibits cell wall synthesizes promoting osmotic instability
INDICATION & DOSAGE >Amebic liver abcess >To prevent post operative infection in contaminated or potentially contaminated colorectal surgery Dosage: 500mg IV
Serious lower respiratory tract infection, UTI, skin structure infection, bone or joint infection, gonorrhea Dosage: 750mg IV
ADVERSE REACTION
NURSING CONSIDERATION
>CNS: headache, seizure, fever, vertigo, ataxia, dizziness >CV: flattened T wave, edema, flushing >EENT: rhinitis, sinusitis, pharyngitis >GI: nausea, abdominal cramping or pain, stomatitis, vomiting, diarrhea >GU: vaginitis, darkened urine, polyuria, dysuria, dyspareunia
> Monitor liver function test result carefully in elderly patient. > Observe pt. for edema especially if receiving corticosteroid >Record number and character of stools when drug is used to treat.
> CV: thrombophleb itis, phlebitis > GI: diarrhea, nausea, vomiting, anorexia > Skin: maculo papular,
> Before giving drugs, ask patient if he allergic to penicillin or cephalosporins > Obtain specimen for culture and sensitivity test before giving first dose
DRUG STUDY
NAME
CLASSIFICATION
ACTION
Generic Name: Metronidazole Brand Name: Flagyl
Antiprotozoals or Antimicrobials
Direct -acting trichomonacide and amebicide that works inside and outside the intestines. It’s thought to enter the cells of microorganisms that contain nitroreductase, forming unstable compounds that bind to DNA and inhibit synthesis, causing cell death.
Generic name: Cefuroxime Brand Name: Zinacef
Cephalosporins
Inhibits cell wall synthesizes promoting osmotic instability
INDICATION & DOSAGE >Amebic liver abcess >To prevent post operative infection in contaminated or potentially contaminated colorectal surgery Dosage: 500mg IV
Serious lower respiratory tract infection, UTI, skin structure infection, bone or joint infection, gonorrhea Dosage: 750mg IV
ADVERSE REACTION
NURSING CONSIDERATION
>CNS: headache, seizure, fever, vertigo, ataxia, dizziness >CV: flattened T wave, edema, flushing >EENT: rhinitis, sinusitis, pharyngitis >GI: nausea, abdominal cramping or pain, stomatitis, vomiting, diarrhea >GU: vaginitis, darkened urine, polyuria, dysuria, dyspareunia
> Monitor liver function test result carefully in elderly patient. > Observe pt. for edema especially if receiving corticosteroid >Record number and character of stools when drug is used to treat.
> CV: thrombophleb itis, phlebitis > GI: diarrhea, nausea, vomiting, anorexia > Skin: maculo papular,
> Before giving drugs, ask patient if he allergic to penicillin or cephalosporins > Obtain specimen for culture and sensitivity test before giving first dose
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