11 April 2009 Mock Saq Exam

1.

Describe factors that affect the duration of action of neuromuscular blocking agents.

( 5 marks )

Explain the characteristics of a non depolarizing neuromuscular blockade. ( 5 marks ) 2.

Define pKa.

( 2 marks )

Discuss the clinical relevance of pKa using an intravenous anaesthetic agent as example ( 8 marks )

3. Outline possible reasons for prolongation of paralysis induced by an intravenous dose of 1 mg/kg of suxamethonium and briefly indicate the consequences of such prolonged block. ( 10 marks )

4.

Outline the clinical effect of oxytocin

5. Classify diuretics and briefly explain their mode of action

6.

( 10 marks )

( 10 marks )

List the drugs used clinically as anticoagulants and antithrombotics and briefly describe their mechanism of action ( 10 marks )