11 April 2009 Mock Mcq Exam

1. The following drugs have volume of distribution greater than 100 litres in 70 kg adults A. Atracurium B. Vecuronium C. Digoxin D. Thiopentone E. Fentanyl

2. Sevoflurane A. Has higher blood/gas partition coefficient than isoflurane B. Is more cardiodepressant than isoflurane C. Has higher MAC value than desflurane D. Is less pungent than desflurane E. Has a faster washout than halothane

3. Diclofenac A. Works by inhibiting lipo-oxygenase B. May increase renal blood flow C. Has anti pyretic properties D. Reversibly promotes platelet aggregation E. May be used in last trimester of pregnancy

4. Dopexamine A. Is a precursor of noradrenaline B. Exerts its predominant effects by stimulating beta-1 adrenoceptors C. Is a weak beta-2 receptor agonist

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D. Reduces atrial filling pressure E. Produces pulmonary hypertension

5. The following antagonized by naloxone A. Dextropropoxyphene B. Midazolam C. Buprenorphine D. Remifentanil E. Thiopentone

6. Tramadol A. Is a controlled drug B. Can be administered intravenously C. Has affinity for binding at the mμ opiod receptor comparable to that morphine D. Acts predominantly by inhibiting the reuptake of noradrenaline and serotonin E. May be used concurrently with MAO inhibitor

7. The following drugs are 5-HT agonist A. Ondasetron B. Granisetron C. Selegiline D. Sumatriptan E. Lamotrigine

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8. Hepatic first pass metabolism A. Is avoided by giving drug transdermally B. Is avoided by giving drug sublingually C. Is avoided by giving drug rectally D. Is avoided by giving drug intramuscular injection E. Is seen when a drug has a high hepatic extraction ratio

9. Factors which may increase the effects of vecuronium include A. Hypermagnesaemia B. Hypokalaemia C. Respiratory acidosis D. Respiratory alkalosis E. Hypothermia

10. Pulmonary fibrosis is an unwanted side effect of A. Amiodarone B. Bleomycin C. Digoxin D. Nitrofurantoin E. Busulphan

11. Uterine tone is reduced by A. Ritodrine B. Vecuronium C. Ketamine

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D. Isoflurane E. Salbutamol

12. The following antibiotic are bacteriostatic A. Gentamicin B. Cefuroxime C. Erythromycin D. Tetracycline E. Vancomycin

13. Remifentanil A. Undergoes hepatic metabolism B. Has a half life of approximately 20 minutes C. Has a short duration of action because of redistribution D. Has a potency similar to fentanyl E. Has prolonged duration of action in patients with pseudocholinesterase deficiency

14. The following drugs may be given via endotracheal tube A. Adrenaline B. Atropine C. Lignocaine D. Sodium bicarbonate E. Calcium chloride

15. Regarding ionisation of the drugs

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A. The pKa of the drug is the pH where the drug is 100% ionized B. Drugs with pKa near to physiological pH will show significant changes in ratio of ionized vs nonionised drug C. The pKa of a drug varies with the pH of the solution D. A drug with an acid pKa will be mainly unionized in the stomach E. Local anaesthetics are less effective in an acidic environment

16. Drugs with a prolonged action in the presence of defective plasma acetylcholinesterase include A. Atracurium B. Prilocaine C. Procaine D. Trimetaphan E. Esmolol

17. Droperidol A. Is a phenothiazine B. Has beta adrenergic actions C. Stimulates alpha receptors D. Is extensively metabolized by the liver E. Can cause extrapyramidal side effects

18. The action of non depolarizing muscle relaxant is prolonged by A. Hyponatraemia B. Hyperkalaemia C. Hypermagnesaemia D. Lithium E. Gentamicin

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19. The following drugs decrease intraocular pressure A. Enflurane B. Nitrous oxide C. Etomidate D. Ketamine E. Suxamethonium

20. Treatment with metformin A. Is a recognized cause of hypoglycaemia in an elderly diabetic patient B. Is a recognized cause of diarrhea C. Reduces serum triglycerides level D. Increases serum insulin concentration E. Is contraindicated in presence of liver disease

21. Regarding log dose-response curves A. Potency is the ability of a drug to produce maximal response B. A partial agonist binds to the receptors with a lower affinity than an agonist C. In the presence of a competitive antagonist the log dose-response curve for an agonist shows a parallel shift to the right D. In the presence of non-competitive antagonist, the log dose-response curve for an agonist is shifted to the right E. A partial agonist can act as a competitive antagonist to a full agonist

22. The following statements are true A. The range is the smallest and the largest observation

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B. The 20th percentile is the point below of which 20% of the data lie C. The median is the 50th centile D. The interquartile range can be used for non-normal distribution E. The interquartile range is define as the data lying between the 25th and 75th centiles

23. For a normal distribution A. 95% of the observations lie within 1standard deviation either side of the mean B. 5% of the observations lie below 2 standard deviations of the mean C. The mean, median and mode are the same D. The standard deviation is an index of reliability of the mean E. The standard error of the mean is generally smaller than the standard deviation

24. The following drugs may increase plasma urea concentration in the presence of normal renal function A. Tetracycline B. Frusemide C. Corticosteroid D. Captopril E. Spironolactone

25. The following drugs have an elimination half-life of greater than 3 hours A. Amiodarone

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B. Thiopentone C. Propofol D. Fentanyl E. Alfentanyl

26. Isoflurane A. Is a fluorinated hydrocarbon B. Have a MAC of 0.5% in 70% nitrous oxide C. Causes less respiratory depression than halothane D. Should not be used with soda lime E. Has a greater oil/gas partition coefficient than enflurane

27. The following drugs are excreted mostly unchanged by the kidneys A. Digoxin B. Gentamicin C. Theophylline D. Morphine E. Vecuronium

28. Drugs which may increase serum potassium concentration include A. Suxamethonium B. Lisinopril C. Nifedipine D. Digoxin E. Bumetanide

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29. Protein binding is affected by A. pH B. age C. renal disease D. liver disease E. pregnancy

30. Drugs contraindicated in malignant hyperthermia include A. Droperidol B. Ketamine C. Etomidate D. Atropine E. Lignocaine

END OF PAPER

Answer 1. FFTTT 2. FFFTT 3. FFTFF 4. FFFTF 5. TFTTF

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6. FTFTF 7. FFFTF 8. TTFTT 9. TTTFT 10. TTFTT 11. TFFTT 12. FFTTF 13. FFFTF 14. TTTFF 15. FTFTT 16. FFTTF 17. FFFTT 18. FFTTT 19. TFTFF 20. FTTFT 21. FFTFT 22. TTTTT 23. FFTFT 24. TFTFF 25. TTTTF 26. FTFFF 27. TTFFF 28. TTFFF 29. TTTTT 30. FFFFF

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