05b Tissue Repair

TISSUE REPAIR • REGENERATION: – REPLACEMENT OF DESTROYED TISSUE WITH SAME TISSUE TYPE

• FIBROSIS: – ACCUMULATION OF FIBROUS CT – CREATION OF SCAR TISSUE

TISSUE REPAIR • 1: INFLAMMATION/ BLEEDING – CAPILLARIES DILATE AND BECOME PERMEABLE • WHITE BLOOD CELLS • CLOTTING PROTEINS

• 2: CLOT FORMATION – STOPS BLEEDING – HOLDS EDGES OF WOUND TOGETHER – SCAB = EXPOSED CLOT

TISSUE REPAIR • 3: ORGANIZATION – GRANULATION TISSUE • NEW CAPILLARY GROWTH • FIBROBLAST PROLIFERATION • NEW COLLAGEN FIBERS

• 4: REGENERATION: – EPITHELIAL TISSUE

• DIFFERENT TISSUES HAVE DIFFERENT ABILITIES TO REGENERATE – VERY GOOD • EPITHELIAL; BONE

– VERY BAD • CARDIAC MUSCLE, NERVE TISSUE

SCARS AND ADHESIONS • SCAR TISSUE: – FIBROUS MASS MADE MOSTLY OF COLLAGEN FIBERS – STRONG – INFLEXIBLE – IMPEDES NORMAL FUNCTIONING OF THE TISSUE IT IS REPLACING

• ADHESION: – NEWLY FORMING SCAR TISSUE CONNECTING ADJACENT ORGANS – RESTRICTS NORMAL MOVEMENTS