W12circulatory Disturbance

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Circulatory disturbances Workshop 12

• • • •

Pulmonary edema Chronic passive congestion - lung Chronic passive congestion - liver Cerebral hemorrhage by erythrodiapedesis

Edema • Edema represents the increase of fluid in interstitium and preformed cavities • Transudate = fluid with density <1012, with a reduced protein content

Pulmonary edema •

Appears in acute left cardiac failure.



Microscopy (histologic section through the lung) The alveolar walls are thickened by:  Parieto-alveolar capillary distension and  Interstitial edema The alveolar lumen:  An eosinophilic, fine granular material, (transudate) that replaces partially or totally the air content.

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Passive congestion

• The passive congestion represents the increase of the blood volume in a tissue or organ (by dilation of the venous and capillary network) as a result of decreased blood return).

Chronic passive congestion of the lung • • -

• -

Appears in the chronic left cardiac failure. Microscopy (histologic section through the lung) The alveolar wall is thickened by distension of parieto-alveolar capillaries. The alveolar lumen:  microhemorrhage (intra-alveolar erythrocytes) prodused by erythrodiapedesis or rupture of capillaries)  siderrophages - hemosidderin leiden macrophages (heart failure cells)  transudate

In evolution: Hemossiderin accumulation Brown induration Parieto-alveolar fibrosis

Chronic passive congestion of the lung

(Perls stain) •

Perls stain = diferentiate the hemosiderin from anthracotic pigment. The hemosiderin is staining in blue



In the alveolar lumen we can see macrophages that contain a granular blue pigment.

Chronic passive congestion of the liver •

Appears in chronic right cardiac failure.

• Microscopy (histological section through the liver)

 The centrolobular veins and the adjacent synusoid capillaries are distended and filled with blood.  The centrolobular hepatocytes – atrophy by compression and hemorrhagic necrosis  The mediolobular hepatocytes – steatosis (anoxia)  The periportal hepathocytes normal

Haemorrhage • Extravasation of blood from normal conducts (heart and vessels during life)

Cerebral haemorrhage by erithrodiapedesis • Microscopy (histological

section through the white cerebral substance  microhemorrhage – small hemorrhagic foci centred by congestive capillaries with intact endotelium  Erithrocytes form a ring around cerebral capillaries produced by erythrodiapedesis (extravasation of erythrocytes from vessel lumen)

Circulatorry disturbance Workshop 13

• Recent arterial thrombosis • Recent renal infarction • Pulmonary hemorrhagic infarction

THROMBOSIS • Represents the process of blood coagulation in heart and vessels during life.

Recent artherial thrombosis •



The artherial thrombosis is produced in artheries with altered endothelium by different lessions (atherosclerosis) Microscopy (transversal section through a muscular arthery)  The vascular lumen is obliterated by a recent thrombus, adherent to the wall.  The thrombus is constituted from an eosinophilic fibrin network, erithrocytes and leukocytes.  The wall is thickened due to a plaque of atherosclerosis.

INFARCTION • Is an aria of circumscribed necrosis determined by sudden interruption of blood flow in a tissue or organ • Classification:  White infarction (anemic) is produced in solid organs with terminal, anastomotical, unfunctional circulation, (heart, kidney, spleen, brain)  Red infarction (hemorrhagic) is produced in organs with loose structure, with double circulation (lung, liver, intestine)

Recent renal infarction •



White infarction (anemic) is produced in the kidney due to obstruction of a renal branch

arthery by an embolus or occlusive thrombus Microscopy (histological section through the kidney)  ischemic, structural, coagulative necrosis  the glomeruli and tubes are intense eosinophilic, without nuclei with preserved cellular limits.

Pulmonary hemorrhagic infarction •

The hemorrhagic infarction is produced in organs with loose structure and double circulation by:  obstruction of a pulmonary arthery by an embolus  in the presence of pulmonary stasis



Microscopy (histological section through the lung) Large area of structural, coagulative necrosis, with preservation of lung structure  The alveolar walls are necrotic with homogeneous, eosinophilic appearance and without nuclei  The alveolar lumen contains a mass of erithrocytes The adjacent pulmonary parenchyma presents lung stasis




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