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1: Med Hypotheses. 1982 Jan;8(1):49-84.
Vitamin C and cancer: examination of the Vale of Leven trial results using broad inductive reasoning.
Related Articles Review A rapid and systematic review of the clinical effectiveness and cost-effectiveness of topotecan for ovarian cancer. [H ea lth Technol Assess. 2001]
Jaffey M. Cameron and Pauling have reported large survival increases in terminal cancer patients treated with Vitamin C. Their trials, which have been criticised because not based on random, double-blind principles, are reviewed here using a broad inductive method that relies on diverse data of varying quality. Conclusions are offered both on the value of Vitamin C and on this broad method, as follows: There is a strong possibility that Vitamin C very approximately doubled survival time as measured from the start of Vitamin C treatment, regardless of whether this was after termination of conventional treatment or much earlier. A recent Mayo Clinic trial which concluded that Vitamin C is valueless in the terminal stage may be given an alternative interpretation which supports this view. Despite a speculative element because based only on the condensed, published data, these conclusions have sufficient possibility of validity as to call for full further investigation. The conclusions on method are that the broad, inductive approach may have potential value when the randomized method cannot be used; that it also may facilitate, to the public's benefit, the release of probably valuable, inexpensive, non-toxic treatments pending decisive proof; and a greater return on the research dollar might result from a formal acceptance of the probabilistic element in scientific proof. PMID: 7038410 [PubMed - indexed for MEDLINE]
Criteria for the validity of clinical trials of treatments of cohorts of cancer patients based on the Hardin Jones principle. [P roc Natl Acad Sci U SA. 1989] Review Design of Physicians' Health Study II--a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, [Ann Epi demiol. 2000] Review Oblimersen: Augmerosen, BCL-2 antisense oligonucleotide - Genta, G 3139, GC 3139, oblimersen sodium. [ Drugs RD. 2007] Review Chemoprevention of bladder cancer. [Uro lClin No rth Am. 2002] » See Reviews...
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Cited by PubMed Central article Review Unconventional therapies for cancer: 5. Vitamins A, C and E. The Task Force on Alternative Therapies of the Canadian Breast Cancer Research [CMAJ. 1998]
Patient Drug Information Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body. Source: AHFS Consumer Medication Information
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