Anatomy of the Ventricles and CSF Physiology Dr F Taleb
Ventricles of the Brain CNS is hollow Develops from a NEURAL TUBE whose
cavity persists Lined with single Epithelial-like layer of cells – Ependyma (cuboidal) Ventricles
Ventricles of the Brain Ventricles contain CSF Secreted in ventricles by choroid plexus CSF necessary for brain development –
Reasons ??
Ventricles of the Brain
Normal brain- 4 ventricles 2 lateral - Cerebal hemispheres 3rd ventricle – Diencephalon 4th Pons and Medullasharing connnections – FOM and AS
Ventricles of the Brain
Lateral ventricles C shaped structure Around the caudate nucleus and white matter of the internal capsule
Ventricles of the Brain
Lateral Ventricles 5 Parts Frontal(anterior) Horn Body Atrium(Trigone) Occipital(posterior) Temporal(inferior)
Ventricles of the Brain
Frontal Horn Anterior to Foramen of Monro Corpus Callosum – roof, anterior part and part of the floor Bulbous head of the caudate nucleus forms the rest of the floor
Ventricles of the Brain
Lateral wall – Caudate nucleus Meets the roof at an angle Medial wall – septum pellucidum- (4 layers 2 pia 2 ependyma) and anterior column of fornix No choroid plexus
Ventricles of the Brain
BODY Behind FOM Floor – Thalamus and body of the caudate nucleus Grove – thalamostriate vein and Stria medullaris (amygdala to ant perf subs)
Ventricles of the Brain
Roof - Corpus Callosum Medial wall – crus and body of the fornix Choroid plexus invaginates between thalamus and fornix – choroid fisssure Covered with 2 layers –pia and ependyma
Ventricles of the Brain
Lateral wall – essentially caudate body Note: the genu of the internal capsule touches the lateral wall lateral to FoM between tha caudate and thalamus
Ventricles of the Brain
Cavity arches downwards and forwards into the Temporal horn and backwards into the occipital horn Atrium/trigone
Ventricles of the Brain
Occipital Horn Most variable Can be absent Floor: collateral eminence – collateral sulcus Medial wall: 2 convexities Upper – bulb – fibres of forceps major
Ventricles of the Brain
Lower - calca avis – calcarine sulcus Can obliterate the occiptal horn when well developed Roof - tapetum of corpus callosum Lateral wall – optic radiation NO choroid plexus
Ventricles of the Brain
Temporal Horn ? Largest Medial part of temporal lobe Ends blindly posterior to amygdaloid body
Ventricles of the Brain
Floor – Hipppocampus medially Collateral eminence laterally
Ventricles of the Brain
Roof – Tail of caudate continuous anteriorly with the amygdaloid boby – lateral to anterior perforated substance Prominence at tip above pes hippo Laterally tapetum
Ventricles of the Brain
Lateral wall – Tapetum
Ventricles of the Brain
Medially – Choroid fissure Lower lip - fimbria Upper lip – tail of caudate
Ventricles of the Brain
Trigone Body - temporal occipital horns converge Base on pulvinar Glomus – tuft of choroid plexus Calcified
Ventricles of the Brain
THIRD VENTRICLE Slit like space in sagital plane Lateral wall thalamus mainly
Ventricles of the Brain
Thalamus bulge of grey matter Interthalamic adhesion(massa intermedia) in 60% of brains only Not a comissure
Ventricles of the Brain
Hypothalamic grove from FoM to AS Hypothalamus below grove including floor Subthalamus caudally merges with midbrain Hypothalamus – supraoptic and paraventricular nuclei
Ventricles of the Brain
Stria meditullaris – runs along superomedial border of thalamus White matter band from piriform area U loop posteriorly habenular comissure Olfactory(like ant commissure)
Ventricles of the Brain
Columns of fornix – prominence from FoM blends in the lateral wall
Ventricles of the Brain
Roof – From FoM to supra pineal recess 4 layers Fornix body 2 layers of pia( tela choroida) Vascular layer between the tela (velum interpositum)
Habenular comm.
Ventricles of the Brain
Choroid plexus hanging from roof in pairs Continuous with choroid plexus of lateral ventricles through FoM and temporal horns(eshaped)
Ventricles of the Brain
Anterior wall – Optic chiasm to FoM Optic chiasm Supra optic recess Lamina terminalis Anterior commissure Columns of fornix
Ventricles of the Brain
Floor – From Optic chiasm to AS Ant ½ diencephalic Post ½ mesencephalic
Ventricles of the Brain
Ant – post Optic chiasm Infundibulum Tuber cinereum(grey)– median eminence – no blood/brain barrier Mamillary bodies (external) Posterior perforated substance
Ventricles of the Brain
Floor Tegmentum AS
Ventricles of the Brain
Posterior wall From supra pineal recess to AS Superior – inferior Supra pineal recess – slack roof pia + ependyma Habenular comm. Pineal body and recess Posterior comm. -Sup colliculi
Ventricles of the Brain
AS Through midbrain Into 4th ventricle
Ventricles of the Brain
FOURTH VENTRICLE Extends from the AS to the central canal Rhomboid shaped cavity over pons and medulla Roof is tent shaped Mainly ependyma
Ventricles of the Brain
Covered by the cerebellum Upper part – over pons – thin sheet of white matter – superior medullary velum Bounded by superior cerebellar peduncles
Ventricles of the Brain
Lower part – over medulla Superiorly Ependyma + white matter from base of flocculus –Inferior medullllary velum Inferiorly Only ependyma and pia Attached to margins of cuneate and gacile nuclei
Ventricles of the Brain
Midline slit Foramen of Magendie Comunicates with cerebellomedullary cistern
Ventricles of the Brain
Lateral recess – laterally Around and behind the inferior cerebellar peduncle Narrow and tubular Opening – lateral aperture-foramen of Luschka
Ventricles of the Brain
Opens anteriorly just behind the VIII nerve Into pontine cistern These are the only exits from the ventricles
Ventricles of the Brain
Choroid plexus is separate Small L – shaped Indents the medullary part of the roof Starts at the lateral aperture from a branch of PICA Lies below flocculus
Ventricles of the Brain
Passes medially Meets the opposite choroid plexus Run down as parallel structures to foramen of Magendie Drains into occipital sinus
Ventricles of the Brain
The Floor Diamond shaped – Rhomboid fossa Upper boundaries – superior and inferior cerebellar peduncles Lower boundaries – gracile and cuneate nucleus
Ventricles of the Brain
Median sulcus – deep grove from AS to central canal Floor symetrical on each side Medullary striae – crosses the floor at its widest part aberrant fibres from pontine nuclei to cerebellum via inferior peduncle
Ventricles of the Brain
Demarcates medullary and pontine parts Overly vestibular area at lateral angle
Ventricles of the Brain
Pontine Part Vestibular area Median eminence insignificant Lower part – bulge – Facial collliculus Overly the recurving fibres of CN VII and the underlying CN VI nucleus
Ventricles of the Brain
Superior fovea – between vestibular area and facial colliculus Locus caerulus – bluish colour due to noradrenergic pigmented cells – part of Reticular Formation
Ventricles of the Brain
Medullary part Smaller than Pontine part Vestibular area Inferior fovea divides the floor into 2 smaller traingles Superior triangle – hypoglossal triangle CN XII nucleus
Ventricles of the Brain
Inferior/lateral triangle – Vagal triangle
CSF Physiology
Entire CNS cavity – Brain and spine 1600 to1700ml 150ml CSF Ventricles Cisterns Subarachnoid space – brain and cord All connected and pressure regulated
CSF Physiology Formation 500 ml/day – 3 to 4 times total vol 2/3 from choroid plexuses Rest
mostly from ependymal surfaces and arachnoidal membranes Small amount from brain itself, through the perivascular spaces Outflow – arachnoid villi in the venous sinuses
CSF Physiology Secretion by the Choroid Plexus Depends on active transport of sodium
ions through the epithelial cells that line the plexus Chloride follows Water follows by osmosis Also small amount of glucose is pumped out and potassium and bicarbonate into the capillaries
CSF Physiology CSF – Osmotic pressure =plasma Sodium conc = plasma Cl 15% > plasma K 40% < plasma Glucose 30%< plasma
CSF Physiology
Absorption Arachnoid villi – microscopic fingerlike projections of the arachnoid membrane into the venous sinuses Conglomerates – macroscopic arachnoid granulations
CSF physiology Endothelial cells -
Large holes through the bodies of the cell Free flow of prot red and white cells into venous sinus Some absorbtion around the spinal nerve roots
CSF Physiology
Perivascular spaces Blood vessels penetrate the brain parenchyma carying a layer of pia mater Loosely packed around – perivascular space Up to arterioles and venules Not capillaries
CSF Physiology Lymphatic Funtion of Perivascular Space No lymphatics in brain Protein leaks into
brain tissue Leaves brain tissue into perivasc spaces then subarachnoid space Thus the protein is scavenged into the CSF. Also removes debris – dead white cells etc
CSF physiology
CSF pressure Normal 13 mm Hg – lying down(5 – 20 mmHg) Regulation of pressure by absorption by the arachnoid villi mainly Production is fairly constant Villi functions as valves No back flow of blood ‘Opening pressure’ of 1.5mmHg
CSF Physiology Blood / fibrosis / particles / proteins can
block the villi Also mechanical blockage around incisura Hydrocephalus
CSF physiology Blood-brain barrier and blood-CSF barrier CSF and brain interstitial fluid different Tight junctions – only selective diffusion Permeable to water, carbon dioxide,
oxygen, and most lipid soluble substances(alcohol and anaesthetic drugs) Slightly permeable to electrolytes Impermeable to protein and hydrophillics
CSF physiology Pia and ependyma are permeable Most substances in the CSF can diffuse
into the brain parenchyma Drugs that do not cross the blood-brain barrier can be injected intrathecally
CSF Physiology Mechanical Cushioning Major function of CSF ! Brain and CSF have the same SG(4%diff) Brain is ‘suspended’ in the vault A blow to the head moves the entire brain
simultaneously
CSF Physiology
Contrecoup Severe blow – cause damage on the opposite side How? Rapid acceleration and deccelration Due to inertia On the initial mvt the brain is cushioned (momentum is diffused) by the CSF – crumple zone Due to the inertia relative CSF deficiency at opposite end. On decceleration brain hits vault with no CSF cushion – No crumple zone - CONTUSION