Systemic Lupus Erythematosus

Systemic Lupus Erythematosus A→ cricoarytenoid arthritis → hoarseness, stridor, or airway obstruction (awake intubation), post-extubation edema B→ effusion, pneumonitis, pul HTN, and alveolar hemorrhage. high correlation of pul HTN with Raynaud's phenomenon in patients with SLE.(CXR, PFT) C→ pericardial effusion, tamponade, Cardiomyopathy, cardiac conduction abnormalities, ↓ ventricular function, and coronary arteritis, noninfectious endocarditis (Libman-Sacks endocarditis) → mitral insufficiency (ECG, ECHO) D→ immunosuppressants (corticosteroids) or cytotoxic drugs (cyclophosphamide, azathioprine, cyclosporine),avoid Drug-induced lupus quinidine, hydralazine, methyldopa, captopril, enalapril, clonidine, isoniazid, H→anti-phospholipid antibodies → thromboembolic complications, anemia R→ common cause of M&M in patients with SLE, CRF CNS→ seizures, stroke, dementia, psychosis, and peripheral neuropathy GI→ peritonitis, pancreatitis, bowel ischemia, protein-losing enteropathy, and lupoid hepatitis