Synth Pro5

Schematic structure of LPS in E. coli. LPS can be divided into three domains. The lipid A domain is the same as endotoxin and contains two acylated GlcNAc-P residues (G). The core domain consists of KDO (K), heptoses (H), and neutral sugars such as galactose. The outer O-antigen consists of units of two to eight sugars repeated many times. (Open hexagons) An unspecified monosaccharide. (Adapted, with permission, from [10] Holst et al. 1996 [© Elsevier Science].)

Figure 21.7. Structure of heptose and KDO. LPS contains several unusual sugars not found in vertebrates.

Figure 21.8. Structure of KDO2–lipid A in E. coli. (Reprinted, with permission, from [11] Raetz 1996.)