Sustained Release-m C Q

1) a)

Which one is notadvantage of sustain release dosage form? less functioning blood drug level b) frequency reduction in dosing decrease convenience and compliance Which one is more difficult to sustain? freely soluble drug

d)

reduction in adverse side effect

b)

slightly soluble drug

c)

insoluble drug

d)

none

3)

Which one is not similar to the term “sustain release dosage form” ? controlled release b) terminally release short acting d) prolonged action

c) 2) a)

a) c)

4) In ideal sustain release dosage form drug level versus time profile should be remaina) constant throughout the therapy b) saw teeth c) saw teeth d) None 5) Sustain release dosage form followsa) zero order and first order kinetics b) zero order and second order kinetics c)

irst order and second order kinetics

6) a)

Which one represents Noyes-Whitny equation-

7)

Which of the following is delayed release drug -

dc/dt = KA(CS-C) c) dc/dt = KA(CS-C)/h a) Aspirin c) Erythromycine

d)

C

A

C

A

A

none

b)

dc/dt = D/hA(CS-C) d) none b) Doxycucline d) All of the above

AB

D

8)

Which one is extended release drug ? a) Oxtriphyline b) Doxycucline c) Erythromycine d) Aspirin 9) Asacol(mesalamine) delayed release tablets coated witha) Carnuba wax b) CAP c) Eudragit S d) PVA

10) a) c) 11) a) c)

Diffusional system recogniged by-Reservoir device b) Matrix device Polymeic device d) Solution Which one is false in case of biodegradable matrix systemEasier to produce reservoir device b) Can deliver high molecular weight compound Difficult to control kinetics d) Removal from implant site is necessary

AD

C

AB

D

12) Which one is not the characteristics of osmotically controlled system (OCS) ? a) Drug surround by semipermeable membrane b) Zero-order release is obtainable c) Release governed by osmotic pressure d) Reformulation is required 13) In osmotically controlled system the rate of flow dv/dt of water into the device can be represent as-

D

a) c)

dv/dt = Ak/h(∆π-∆p) None of them

B

Four system

D

dv/dt = Ak.h(∆π-∆p)

dv/dt = Ak/h(∆t-∆p) 14) Osmotically controlled system appear ina) Three system

b) d)

b) d)

c) Six system 15) The lower limit on solubility for sustain drugs should be –

Two system

a) 0.01 mg/ml b) 0.1 mg/ml c) 0.2 mg/ml d) 0.301g/ml 16) For oral dosage form in sustain release system the lower limit on absorption rate constant is in the range of-

a) c) 17) a) c) 18) a) c)

0.24 h-1 -1

b) d)

0.025 min-1

B

D

-1

0.63h 0.25h In sustain release system oralproduct has a dose sizeGreater than 0.5 gm b) Smaller than 0.5gm Greater than 0.2 gm d) None of the above For sustained drug delivery the sustaining portion is determined by multiplying theZero order rate constant b) First order rate constant Blood concentration nute d) Second order rate constant

A

A

19) Which of the following plays major rule in sustained release system-a) Biological half life c) a+b

b) Duration of action d) none

C

20) Reservoir diffusional system follows -a) First order kinetics c) second order kinetics

b) Zero order kinetics d) none

B